Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations

Hypertension is a leading cause of global disease, mortality, and disability. While individuals of African descent suffer a disproportionate burden of hypertension and its complications, they have been underrepresented in genetic studies. To identify novel susceptibility loci for blood pressure and...

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Veröffentlicht in:	PLoS genetics 2017-05, Vol.13 (5), p.e1006728-e1006728
Hauptverfasser:	Liang, Jingjing, Le, Thu H, Edwards, Digna R Velez, Tayo, Bamidele O, Gaulton, Kyle J, Smith, Jennifer A, Lu, Yingchang, Jensen, Richard A, Chen, Guanjie, Yanek, Lisa R, Schwander, Karen, Tajuddin, Salman M, Sofer, Tamar, Kim, Wonji, Kayima, James, McKenzie, Colin A, Fox, Ervin, Nalls, Michael A, Young, J Hunter, Sun, Yan V, Lane, Jacqueline M, Cechova, Sylvia, Zhou, Jie, Tang, Hua, Fornage, Myriam, Musani, Solomon K, Wang, Heming, Lee, Juyoung, Adeyemo, Adebowale, Dreisbach, Albert W, Forrester, Terrence, Chu, Pei-Lun, Cappola, Anne, Evans, Michele K, Morrison, Alanna C, Martin, Lisa W, Wiggins, Kerri L, Hui, Qin, Zhao, Wei, Jackson, Rebecca D, Ware, Erin B, Faul, Jessica D, Reiner, Alex P, Bray, Michael, Denny, Joshua C, Mosley, Thomas H, Palmas, Walter, Guo, Xiuqing, Papanicolaou, George J, Penman, Alan D, Polak, Joseph F, Rice, Kenneth, Taylor, Ken D, Boerwinkle, Eric, Bottinger, Erwin P, Liu, Kiang, Risch, Neil, Hunt, Steven C, Kooperberg, Charles, Zonderman, Alan B, Laurie, Cathy C, Becker, Diane M, Cai, Jianwen, Loos, Ruth J F, Psaty, Bruce M, Weir, David R, Kardia, Sharon L R, Arnett, Donna K, Won, Sungho, Edwards, Todd L, Redline, Susan, Cooper, Richard S, Rao, D C, Rotter, Jerome I, Rotimi, Charles, Levy, Daniel, Chakravarti, Aravinda, Zhu, Xiaofeng, Franceschini, Nora
Format:	Artikel
Sprache:	eng
Schlagworte:	Africans Aging Analysis Angiotensin Angiotensin II Animals Basic Helix-Loop-Helix Transcription Factors - genetics Bioinformatics Biology and Life Sciences Black or African American - genetics Blood pressure Blood Pressure - genetics Cadherins - genetics Case-Control Studies Descent Enrichment Epidemiology Female Functional anatomy Gene expression Genes Genetic aspects Genetic Loci Genetics Genome-wide association studies Genome-Wide Association Study Genomes Genomics Health aspects Health care Health sciences Heart Humans Hypertension Hypertension - ethnology Hypertension - genetics Internal medicine Laboratories Loci Male Medical research Medicine and Health Sciences Membrane Proteins - genetics Meta-analysis Metabolism Mice Mortality Multifactorial Inheritance Nephrology People and Places Physical Sciences Polymorphism, Single Nucleotide Population genetics Population studies Preventive medicine Principal components analysis Public health Research and Analysis Methods Research centers Studies Transcription University colleges
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