MAGERI: Computational pipeline for molecular-barcoded targeted resequencing

Unique molecular identifiers (UMIs) show outstanding performance in targeted high-throughput resequencing, being the most promising approach for the accurate identification of rare variants in complex DNA samples. This approach has application in multiple areas, including cancer diagnostics, thus de...

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Veröffentlicht in:	PLoS computational biology 2017-05, Vol.13 (5), p.e1005480-e1005480
Hauptverfasser:	Shugay, Mikhail, Zaretsky, Andrew R, Shagin, Dmitriy A, Shagina, Irina A, Volchenkov, Ivan A, Shelenkov, Andrew A, Lebedin, Mikhail Y, Bagaev, Dmitriy V, Lukyanov, Sergey, Chudakov, Dmitriy M
Format:	Artikel
Sprache:	eng
Schlagworte:	Accuracy Algorithms Bioinformatics Biological properties Biological samples Biology and Life Sciences Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Cancer Computational Biology - methods Computer applications Computer programs Databases, Genetic Datasets Deoxyribonucleic acid DNA DNA sequencing Drug resistance Fidelity Genetic testing Genomes High-Throughput Nucleotide Sequencing - methods Humans Medicine and Health Sciences Methods Mitochondrial DNA Mutation Neoplasms - genetics Research and Analysis Methods Ribonucleic acid RNA RNA, Viral - genetics Sequence Analysis, DNA - methods Sequence Analysis, RNA - methods Software Studies
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