Overexpression of the essential Sis1 chaperone reduces TDP-43 effects on toxicity and proteolysis

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by selective loss of motor neurons with inclusions frequently containing the RNA/DNA binding protein TDP-43. Using a yeast model of ALS exhibiting TDP-43 dependent toxicity, we now show that TDP-43 overexpre...

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Veröffentlicht in:	PLoS genetics 2017-05, Vol.13 (5), p.e1006805
Hauptverfasser:	Park, Sei-Kyoung, Hong, Joo Y, Arslan, Fatih, Kanneganti, Vydehi, Patel, Basant, Tietsort, Alex, Tank, Elizabeth M H, Li, Xingli, Barmada, Sami J, Liebman, Susan W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Analysis Animals Biology and Life Sciences Cell size Cells, Cultured Cortex Deoxyribonucleic acid Disease DNA DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gene expression Genetic aspects Health aspects Homology HSP40 Heat-Shock Proteins - genetics HSP40 Heat-Shock Proteins - metabolism Hsp40 protein Mammals Medicine and Health Sciences Molecular chaperones Motor neurons Motor task performance Mutation Nervous system diseases Neurology Neurons Neurons - metabolism Neuroprotection Pharmacology Physical Sciences Protein Binding Proteins Proteolysis Rats Rats, Long-Evans Research and Analysis Methods Ribonucleic acid Risk factors RNA Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sclerosis Toxicity Ubiquitin Ubiquitin - metabolism Yeast
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