Power provides protection: Genetic robustness in yeast depends on the capacity to generate energy

The functional basis of genetic robustness, the ability of organisms to suppress the effects of mutations, remains incompletely understood. We exposed a set of 15 strains of Saccharomyces cerevisiae form diverse environments to increasing doses of the chemical mutagen EMS. The number of the resultin...

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Veröffentlicht in:	PLoS genetics 2017-05, Vol.13 (5), p.e1006768
Hauptverfasser:	Plech, Marcin, Tomala, Katarzyna, Tutaj, Hanna, Piwcewicz, Dominika Ewa, de Visser, J Arjan G M, Korona, Ryszard
Format:	Artikel
Sprache:	eng
Schlagworte:	Baking yeast Biology and Life Sciences Buffers Carbon sources Cell division Cytochrome c Cytochromes c - biosynthesis Cytochromes c - genetics Electron transport Electron transport chain EMS Energy metabolism Energy Metabolism - genetics Environmental science Ethyl Methanesulfonate - toxicity Functional anatomy Fungi Gene expression Gene Expression Regulation, Fungal - drug effects Gene mutation Gene-Environment Interaction Genes Genetic aspects Genetics Genomes Growth rate Laboratories Laboratorium voor Erfelijkheidsleer Laboratory of Genetics Medicine and Health Sciences Membrane proteins Metabolism Mitochondria - drug effects Mitochondria - genetics Mitochondria - metabolism Molecular biology Mortality Mutagenesis - drug effects Mutation Mutation - genetics Oxidative metabolism Oxidative Phosphorylation - drug effects PE&RC Proteins Quality control Research and Analysis Methods RNA polymerase Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - metabolism Transcription Yeast
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