Paradoxical myeloid-derived suppressor cell reduction in the bone marrow of SIV chronically infected macaques

Myeloid derived suppressor cells (MDSCs), which suppress anti-tumor or anti-viral immune responses, are expanded in the peripheral blood and tissues of patients/animals with cancer or viral infectious diseases. We here show that in chronic SIV infection of Indian rhesus macaques, the frequency of MD...

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Veröffentlicht in:	PLoS pathogens 2017-05, Vol.13 (5), p.e1006395-e1006395
Hauptverfasser:	Sui, Yongjun, Frey, Blake, Wang, Yichuan, Billeskov, Rolf, Kulkarni, Shweta, McKinnon, Katherine, Rourke, Tracy, Fritts, Linda, Miller, Christopher J, Berzofsky, Jay A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals Antiviral agents Biology and life sciences Blood Bone marrow Bone Marrow - immunology Bone Marrow - virology Cancer CD14 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8 antigen Cell activation Chronic infection Correlation Depletion Disease control Disease Models, Animal Diseases Female Health aspects HIV Human immunodeficiency virus Humans Hypotheses Immune response Infectious diseases Lymphocyte Activation Lymphocytes T Macaca mulatta Male Medicine and Health Sciences Myeloid-Derived Suppressor Cells - immunology Patients Peripheral blood Primates Replenishment Replication Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - immunology Simian Immunodeficiency Virus - physiology Suppressor cells Tissues Viral infections Viral Load Virus Replication
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