Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques
Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report...
Gespeichert in:
| Veröffentlicht in: | PLoS pathogens 2017-05, Vol.13 (5), p.e1006378-e1006378 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e1006378 |
|---|---|
| container_issue | 5 |
| container_start_page | e1006378 |
| container_title | PLoS pathogens |
| container_volume | 13 |
| creator | Nguyen, Sydney M Antony, Kathleen M Dudley, Dawn M Kohn, Sarah Simmons, Heather A Wolfe, Bryce Salamat, M Shahriar Teixeira, Leandro B C Wiepz, Gregory J Thoong, Troy H Aliota, Matthew T Weiler, Andrea M Barry, Gabrielle L Weisgrau, Kim L Vosler, Logan J Mohns, Mariel S Breitbach, Meghan E Stewart, Laurel M Rasheed, Mustafa N Newman, Christina M Graham, Michael E Wieben, Oliver E Turski, Patrick A Johnson, Kevin M Post, Jennifer Hayes, Jennifer M Schultz-Darken, Nancy Schotzko, Michele L Eudailey, Josh A Permar, Sallie R Rakasz, Eva G Mohr, Emma L Capuano, 3rd, Saverio Tarantal, Alice F Osorio, Jorge E O'Connor, Shelby L Friedrich, Thomas C O'Connor, David H Golos, Thaddeus G |
| description | Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated. |
| doi_str_mv | 10.1371/journal.ppat.1006378 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1910461982</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A493733511</galeid><doaj_id>oai_doaj_org_article_c7d96184abee40dd90777c869ba3f514</doaj_id><sourcerecordid>A493733511</sourcerecordid><originalsourceid>FETCH-LOGICAL-c620t-f94d368e15f1709f63c98509d867d50b5337ed3d27177c4df564ecf77ec68b0a3</originalsourceid><addsrcrecordid>eNptUk1v1TAQjBCIlsI_QBCJC5c87PgzF6SqAlqpEgfgwsXa-CPPjyQOdlKp_x6Hl1Yt4mTLOzuzO56ieI3RDhOBPxzCEkfod9ME8w4jxImQT4pTzBipBBH06YP7SfEipQNCFBPMnxcntWS0ZpKdFt8ufbfvb0vrnNfejnM5wGxX4srZGfryp_8F5Y2PSyrnCGMafEo-jKUfyynaboTcEvc25foAGn4vNr0snjnok321nWfFj8-fvl9cVtdfv1xdnF9XmtdorlxDDeHSYuawQI3jRDeSocZILgxDLSNEWENMLbAQmhrHOLXaCWE1ly0Ccla8PfJOfUhq8yMp3GBEOW5knRFXR4QJcFBT9APEWxXAq78PIXYK4ux1b5UWpuFYUmitpciYBomsKnnTAnEM08z1cVNb2sEanb2K0D8ifVwZ_V514UYxSqkkOBO83whiWG2aVfZS276H0YZlnRvl30F1zTL03T_Q_2-3oTrIC_jRhayrV1J1ThsiCGF4laVHlI4hpWjd_cgYqTVJd9xqTZLakpTb3jxc977pLjrkD4qCxoI</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1910461982</pqid></control><display><type>article</type><title>Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques</title><source>Public Library of Science (PLoS) Journals Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Nguyen, Sydney M ; Antony, Kathleen M ; Dudley, Dawn M ; Kohn, Sarah ; Simmons, Heather A ; Wolfe, Bryce ; Salamat, M Shahriar ; Teixeira, Leandro B C ; Wiepz, Gregory J ; Thoong, Troy H ; Aliota, Matthew T ; Weiler, Andrea M ; Barry, Gabrielle L ; Weisgrau, Kim L ; Vosler, Logan J ; Mohns, Mariel S ; Breitbach, Meghan E ; Stewart, Laurel M ; Rasheed, Mustafa N ; Newman, Christina M ; Graham, Michael E ; Wieben, Oliver E ; Turski, Patrick A ; Johnson, Kevin M ; Post, Jennifer ; Hayes, Jennifer M ; Schultz-Darken, Nancy ; Schotzko, Michele L ; Eudailey, Josh A ; Permar, Sallie R ; Rakasz, Eva G ; Mohr, Emma L ; Capuano, 3rd, Saverio ; Tarantal, Alice F ; Osorio, Jorge E ; O'Connor, Shelby L ; Friedrich, Thomas C ; O'Connor, David H ; Golos, Thaddeus G</creator><creatorcontrib>Nguyen, Sydney M ; Antony, Kathleen M ; Dudley, Dawn M ; Kohn, Sarah ; Simmons, Heather A ; Wolfe, Bryce ; Salamat, M Shahriar ; Teixeira, Leandro B C ; Wiepz, Gregory J ; Thoong, Troy H ; Aliota, Matthew T ; Weiler, Andrea M ; Barry, Gabrielle L ; Weisgrau, Kim L ; Vosler, Logan J ; Mohns, Mariel S ; Breitbach, Meghan E ; Stewart, Laurel M ; Rasheed, Mustafa N ; Newman, Christina M ; Graham, Michael E ; Wieben, Oliver E ; Turski, Patrick A ; Johnson, Kevin M ; Post, Jennifer ; Hayes, Jennifer M ; Schultz-Darken, Nancy ; Schotzko, Michele L ; Eudailey, Josh A ; Permar, Sallie R ; Rakasz, Eva G ; Mohr, Emma L ; Capuano, 3rd, Saverio ; Tarantal, Alice F ; Osorio, Jorge E ; O'Connor, Shelby L ; Friedrich, Thomas C ; O'Connor, David H ; Golos, Thaddeus G</creatorcontrib><description>Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.</description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1006378</identifier><identifier>PMID: 28542585</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Amniotic Fluid - virology ; Animals ; Anomalies ; Biology and life sciences ; Cesarean section ; Cytomegalovirus ; Decidua ; Decidua - pathology ; Decidua - virology ; Disease Models, Animal ; Disease transmission ; Diseases and pests ; Distribution ; Female ; Femur ; Fetal Development ; Fetus ; Fetuses ; Gestation ; Gynecology ; Health aspects ; Humans ; Infections ; Infectious Disease Transmission, Vertical ; Infiltration ; Laboratories ; Leukocytes (neutrophilic) ; Listeria ; Lung - pathology ; Lung - virology ; Macaca mulatta ; Medicine ; Medicine and Health Sciences ; Membranes ; Monkeys & apes ; Obstetrics ; Optic nerve ; Pathology ; Pediatrics ; Physiological aspects ; Placenta ; Placenta - pathology ; Placenta - virology ; Pregnancy ; Pregnancy Complications, Infectious ; Primates ; Research and Analysis Methods ; Retina ; Ribonucleic acid ; Risk analysis ; Risk factors ; RNA ; RNA, Viral - analysis ; Spleen - pathology ; Spleen - virology ; Therapeutic applications ; Tissues ; Ultrasonic imaging ; Ultrasound ; Umbilical Cord - pathology ; Umbilical Cord - virology ; Vaccines ; Vector-borne diseases ; Velocity ; Viremia ; Viruses ; Zika virus ; Zika Virus - physiology ; Zika Virus Infection - pathology ; Zika Virus Infection - transmission ; Zika Virus Infection - virology</subject><ispartof>PLoS pathogens, 2017-05, Vol.13 (5), p.e1006378-e1006378</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Nguyen SM, Antony KM, Dudley DM, Kohn S, Simmons HA, Wolfe B, et al. (2017) Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. PLoS Pathog 13(5): e1006378. https://doi.org/10.1371/journal.ppat.1006378</rights><rights>2017 Nguyen et al 2017 Nguyen et al</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: Nguyen SM, Antony KM, Dudley DM, Kohn S, Simmons HA, Wolfe B, et al. (2017) Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques. PLoS Pathog 13(5): e1006378. https://doi.org/10.1371/journal.ppat.1006378</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c620t-f94d368e15f1709f63c98509d867d50b5337ed3d27177c4df564ecf77ec68b0a3</citedby><cites>FETCH-LOGICAL-c620t-f94d368e15f1709f63c98509d867d50b5337ed3d27177c4df564ecf77ec68b0a3</cites><orcidid>0000-0002-4037-5486 ; 0000-0003-2139-470X ; 0000-0002-7931-1930 ; 0000-0002-2213-9332 ; 0000-0002-1354-7078 ; 0000-0001-9831-6895 ; 0000-0003-0418-8816 ; 0000-0001-9960-678X ; 0000-0003-3537-8030 ; 0000-0002-8660-0853 ; 0000-0002-8436-2820 ; 0000-0002-6902-9149 ; 0000-0002-1731-9806 ; 0000-0002-7897-4337 ; 0000-0002-8453-7256 ; 0000-0003-0742-305X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444831/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444831/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28542585$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nguyen, Sydney M</creatorcontrib><creatorcontrib>Antony, Kathleen M</creatorcontrib><creatorcontrib>Dudley, Dawn M</creatorcontrib><creatorcontrib>Kohn, Sarah</creatorcontrib><creatorcontrib>Simmons, Heather A</creatorcontrib><creatorcontrib>Wolfe, Bryce</creatorcontrib><creatorcontrib>Salamat, M Shahriar</creatorcontrib><creatorcontrib>Teixeira, Leandro B C</creatorcontrib><creatorcontrib>Wiepz, Gregory J</creatorcontrib><creatorcontrib>Thoong, Troy H</creatorcontrib><creatorcontrib>Aliota, Matthew T</creatorcontrib><creatorcontrib>Weiler, Andrea M</creatorcontrib><creatorcontrib>Barry, Gabrielle L</creatorcontrib><creatorcontrib>Weisgrau, Kim L</creatorcontrib><creatorcontrib>Vosler, Logan J</creatorcontrib><creatorcontrib>Mohns, Mariel S</creatorcontrib><creatorcontrib>Breitbach, Meghan E</creatorcontrib><creatorcontrib>Stewart, Laurel M</creatorcontrib><creatorcontrib>Rasheed, Mustafa N</creatorcontrib><creatorcontrib>Newman, Christina M</creatorcontrib><creatorcontrib>Graham, Michael E</creatorcontrib><creatorcontrib>Wieben, Oliver E</creatorcontrib><creatorcontrib>Turski, Patrick A</creatorcontrib><creatorcontrib>Johnson, Kevin M</creatorcontrib><creatorcontrib>Post, Jennifer</creatorcontrib><creatorcontrib>Hayes, Jennifer M</creatorcontrib><creatorcontrib>Schultz-Darken, Nancy</creatorcontrib><creatorcontrib>Schotzko, Michele L</creatorcontrib><creatorcontrib>Eudailey, Josh A</creatorcontrib><creatorcontrib>Permar, Sallie R</creatorcontrib><creatorcontrib>Rakasz, Eva G</creatorcontrib><creatorcontrib>Mohr, Emma L</creatorcontrib><creatorcontrib>Capuano, 3rd, Saverio</creatorcontrib><creatorcontrib>Tarantal, Alice F</creatorcontrib><creatorcontrib>Osorio, Jorge E</creatorcontrib><creatorcontrib>O'Connor, Shelby L</creatorcontrib><creatorcontrib>Friedrich, Thomas C</creatorcontrib><creatorcontrib>O'Connor, David H</creatorcontrib><creatorcontrib>Golos, Thaddeus G</creatorcontrib><title>Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description>Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.</description><subject>Amniotic Fluid - virology</subject><subject>Animals</subject><subject>Anomalies</subject><subject>Biology and life sciences</subject><subject>Cesarean section</subject><subject>Cytomegalovirus</subject><subject>Decidua</subject><subject>Decidua - pathology</subject><subject>Decidua - virology</subject><subject>Disease Models, Animal</subject><subject>Disease transmission</subject><subject>Diseases and pests</subject><subject>Distribution</subject><subject>Female</subject><subject>Femur</subject><subject>Fetal Development</subject><subject>Fetus</subject><subject>Fetuses</subject><subject>Gestation</subject><subject>Gynecology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Infiltration</subject><subject>Laboratories</subject><subject>Leukocytes (neutrophilic)</subject><subject>Listeria</subject><subject>Lung - pathology</subject><subject>Lung - virology</subject><subject>Macaca mulatta</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Membranes</subject><subject>Monkeys & apes</subject><subject>Obstetrics</subject><subject>Optic nerve</subject><subject>Pathology</subject><subject>Pediatrics</subject><subject>Physiological aspects</subject><subject>Placenta</subject><subject>Placenta - pathology</subject><subject>Placenta - virology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious</subject><subject>Primates</subject><subject>Research and Analysis Methods</subject><subject>Retina</subject><subject>Ribonucleic acid</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>Spleen - pathology</subject><subject>Spleen - virology</subject><subject>Therapeutic applications</subject><subject>Tissues</subject><subject>Ultrasonic imaging</subject><subject>Ultrasound</subject><subject>Umbilical Cord - pathology</subject><subject>Umbilical Cord - virology</subject><subject>Vaccines</subject><subject>Vector-borne diseases</subject><subject>Velocity</subject><subject>Viremia</subject><subject>Viruses</subject><subject>Zika virus</subject><subject>Zika Virus - physiology</subject><subject>Zika Virus Infection - pathology</subject><subject>Zika Virus Infection - transmission</subject><subject>Zika Virus Infection - virology</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1TAQjBCIlsI_QBCJC5c87PgzF6SqAlqpEgfgwsXa-CPPjyQOdlKp_x6Hl1Yt4mTLOzuzO56ieI3RDhOBPxzCEkfod9ME8w4jxImQT4pTzBipBBH06YP7SfEipQNCFBPMnxcntWS0ZpKdFt8ufbfvb0vrnNfejnM5wGxX4srZGfryp_8F5Y2PSyrnCGMafEo-jKUfyynaboTcEvc25foAGn4vNr0snjnok321nWfFj8-fvl9cVtdfv1xdnF9XmtdorlxDDeHSYuawQI3jRDeSocZILgxDLSNEWENMLbAQmhrHOLXaCWE1ly0Ccla8PfJOfUhq8yMp3GBEOW5knRFXR4QJcFBT9APEWxXAq78PIXYK4ux1b5UWpuFYUmitpciYBomsKnnTAnEM08z1cVNb2sEanb2K0D8ifVwZ_V514UYxSqkkOBO83whiWG2aVfZS276H0YZlnRvl30F1zTL03T_Q_2-3oTrIC_jRhayrV1J1ThsiCGF4laVHlI4hpWjd_cgYqTVJd9xqTZLakpTb3jxc977pLjrkD4qCxoI</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Nguyen, Sydney M</creator><creator>Antony, Kathleen M</creator><creator>Dudley, Dawn M</creator><creator>Kohn, Sarah</creator><creator>Simmons, Heather A</creator><creator>Wolfe, Bryce</creator><creator>Salamat, M Shahriar</creator><creator>Teixeira, Leandro B C</creator><creator>Wiepz, Gregory J</creator><creator>Thoong, Troy H</creator><creator>Aliota, Matthew T</creator><creator>Weiler, Andrea M</creator><creator>Barry, Gabrielle L</creator><creator>Weisgrau, Kim L</creator><creator>Vosler, Logan J</creator><creator>Mohns, Mariel S</creator><creator>Breitbach, Meghan E</creator><creator>Stewart, Laurel M</creator><creator>Rasheed, Mustafa N</creator><creator>Newman, Christina M</creator><creator>Graham, Michael E</creator><creator>Wieben, Oliver E</creator><creator>Turski, Patrick A</creator><creator>Johnson, Kevin M</creator><creator>Post, Jennifer</creator><creator>Hayes, Jennifer M</creator><creator>Schultz-Darken, Nancy</creator><creator>Schotzko, Michele L</creator><creator>Eudailey, Josh A</creator><creator>Permar, Sallie R</creator><creator>Rakasz, Eva G</creator><creator>Mohr, Emma L</creator><creator>Capuano, 3rd, Saverio</creator><creator>Tarantal, Alice F</creator><creator>Osorio, Jorge E</creator><creator>O'Connor, Shelby L</creator><creator>Friedrich, Thomas C</creator><creator>O'Connor, David H</creator><creator>Golos, Thaddeus G</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4037-5486</orcidid><orcidid>https://orcid.org/0000-0003-2139-470X</orcidid><orcidid>https://orcid.org/0000-0002-7931-1930</orcidid><orcidid>https://orcid.org/0000-0002-2213-9332</orcidid><orcidid>https://orcid.org/0000-0002-1354-7078</orcidid><orcidid>https://orcid.org/0000-0001-9831-6895</orcidid><orcidid>https://orcid.org/0000-0003-0418-8816</orcidid><orcidid>https://orcid.org/0000-0001-9960-678X</orcidid><orcidid>https://orcid.org/0000-0003-3537-8030</orcidid><orcidid>https://orcid.org/0000-0002-8660-0853</orcidid><orcidid>https://orcid.org/0000-0002-8436-2820</orcidid><orcidid>https://orcid.org/0000-0002-6902-9149</orcidid><orcidid>https://orcid.org/0000-0002-1731-9806</orcidid><orcidid>https://orcid.org/0000-0002-7897-4337</orcidid><orcidid>https://orcid.org/0000-0002-8453-7256</orcidid><orcidid>https://orcid.org/0000-0003-0742-305X</orcidid></search><sort><creationdate>20170501</creationdate><title>Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques</title><author>Nguyen, Sydney M ; Antony, Kathleen M ; Dudley, Dawn M ; Kohn, Sarah ; Simmons, Heather A ; Wolfe, Bryce ; Salamat, M Shahriar ; Teixeira, Leandro B C ; Wiepz, Gregory J ; Thoong, Troy H ; Aliota, Matthew T ; Weiler, Andrea M ; Barry, Gabrielle L ; Weisgrau, Kim L ; Vosler, Logan J ; Mohns, Mariel S ; Breitbach, Meghan E ; Stewart, Laurel M ; Rasheed, Mustafa N ; Newman, Christina M ; Graham, Michael E ; Wieben, Oliver E ; Turski, Patrick A ; Johnson, Kevin M ; Post, Jennifer ; Hayes, Jennifer M ; Schultz-Darken, Nancy ; Schotzko, Michele L ; Eudailey, Josh A ; Permar, Sallie R ; Rakasz, Eva G ; Mohr, Emma L ; Capuano, 3rd, Saverio ; Tarantal, Alice F ; Osorio, Jorge E ; O'Connor, Shelby L ; Friedrich, Thomas C ; O'Connor, David H ; Golos, Thaddeus G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c620t-f94d368e15f1709f63c98509d867d50b5337ed3d27177c4df564ecf77ec68b0a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Amniotic Fluid - virology</topic><topic>Animals</topic><topic>Anomalies</topic><topic>Biology and life sciences</topic><topic>Cesarean section</topic><topic>Cytomegalovirus</topic><topic>Decidua</topic><topic>Decidua - pathology</topic><topic>Decidua - virology</topic><topic>Disease Models, Animal</topic><topic>Disease transmission</topic><topic>Diseases and pests</topic><topic>Distribution</topic><topic>Female</topic><topic>Femur</topic><topic>Fetal Development</topic><topic>Fetus</topic><topic>Fetuses</topic><topic>Gestation</topic><topic>Gynecology</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Infiltration</topic><topic>Laboratories</topic><topic>Leukocytes (neutrophilic)</topic><topic>Listeria</topic><topic>Lung - pathology</topic><topic>Lung - virology</topic><topic>Macaca mulatta</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Membranes</topic><topic>Monkeys & apes</topic><topic>Obstetrics</topic><topic>Optic nerve</topic><topic>Pathology</topic><topic>Pediatrics</topic><topic>Physiological aspects</topic><topic>Placenta</topic><topic>Placenta - pathology</topic><topic>Placenta - virology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious</topic><topic>Primates</topic><topic>Research and Analysis Methods</topic><topic>Retina</topic><topic>Ribonucleic acid</topic><topic>Risk analysis</topic><topic>Risk factors</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>Spleen - pathology</topic><topic>Spleen - virology</topic><topic>Therapeutic applications</topic><topic>Tissues</topic><topic>Ultrasonic imaging</topic><topic>Ultrasound</topic><topic>Umbilical Cord - pathology</topic><topic>Umbilical Cord - virology</topic><topic>Vaccines</topic><topic>Vector-borne diseases</topic><topic>Velocity</topic><topic>Viremia</topic><topic>Viruses</topic><topic>Zika virus</topic><topic>Zika Virus - physiology</topic><topic>Zika Virus Infection - pathology</topic><topic>Zika Virus Infection - transmission</topic><topic>Zika Virus Infection - virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nguyen, Sydney M</creatorcontrib><creatorcontrib>Antony, Kathleen M</creatorcontrib><creatorcontrib>Dudley, Dawn M</creatorcontrib><creatorcontrib>Kohn, Sarah</creatorcontrib><creatorcontrib>Simmons, Heather A</creatorcontrib><creatorcontrib>Wolfe, Bryce</creatorcontrib><creatorcontrib>Salamat, M Shahriar</creatorcontrib><creatorcontrib>Teixeira, Leandro B C</creatorcontrib><creatorcontrib>Wiepz, Gregory J</creatorcontrib><creatorcontrib>Thoong, Troy H</creatorcontrib><creatorcontrib>Aliota, Matthew T</creatorcontrib><creatorcontrib>Weiler, Andrea M</creatorcontrib><creatorcontrib>Barry, Gabrielle L</creatorcontrib><creatorcontrib>Weisgrau, Kim L</creatorcontrib><creatorcontrib>Vosler, Logan J</creatorcontrib><creatorcontrib>Mohns, Mariel S</creatorcontrib><creatorcontrib>Breitbach, Meghan E</creatorcontrib><creatorcontrib>Stewart, Laurel M</creatorcontrib><creatorcontrib>Rasheed, Mustafa N</creatorcontrib><creatorcontrib>Newman, Christina M</creatorcontrib><creatorcontrib>Graham, Michael E</creatorcontrib><creatorcontrib>Wieben, Oliver E</creatorcontrib><creatorcontrib>Turski, Patrick A</creatorcontrib><creatorcontrib>Johnson, Kevin M</creatorcontrib><creatorcontrib>Post, Jennifer</creatorcontrib><creatorcontrib>Hayes, Jennifer M</creatorcontrib><creatorcontrib>Schultz-Darken, Nancy</creatorcontrib><creatorcontrib>Schotzko, Michele L</creatorcontrib><creatorcontrib>Eudailey, Josh A</creatorcontrib><creatorcontrib>Permar, Sallie R</creatorcontrib><creatorcontrib>Rakasz, Eva G</creatorcontrib><creatorcontrib>Mohr, Emma L</creatorcontrib><creatorcontrib>Capuano, 3rd, Saverio</creatorcontrib><creatorcontrib>Tarantal, Alice F</creatorcontrib><creatorcontrib>Osorio, Jorge E</creatorcontrib><creatorcontrib>O'Connor, Shelby L</creatorcontrib><creatorcontrib>Friedrich, Thomas C</creatorcontrib><creatorcontrib>O'Connor, David H</creatorcontrib><creatorcontrib>Golos, Thaddeus G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PLoS pathogens</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nguyen, Sydney M</au><au>Antony, Kathleen M</au><au>Dudley, Dawn M</au><au>Kohn, Sarah</au><au>Simmons, Heather A</au><au>Wolfe, Bryce</au><au>Salamat, M Shahriar</au><au>Teixeira, Leandro B C</au><au>Wiepz, Gregory J</au><au>Thoong, Troy H</au><au>Aliota, Matthew T</au><au>Weiler, Andrea M</au><au>Barry, Gabrielle L</au><au>Weisgrau, Kim L</au><au>Vosler, Logan J</au><au>Mohns, Mariel S</au><au>Breitbach, Meghan E</au><au>Stewart, Laurel M</au><au>Rasheed, Mustafa N</au><au>Newman, Christina M</au><au>Graham, Michael E</au><au>Wieben, Oliver E</au><au>Turski, Patrick A</au><au>Johnson, Kevin M</au><au>Post, Jennifer</au><au>Hayes, Jennifer M</au><au>Schultz-Darken, Nancy</au><au>Schotzko, Michele L</au><au>Eudailey, Josh A</au><au>Permar, Sallie R</au><au>Rakasz, Eva G</au><au>Mohr, Emma L</au><au>Capuano, 3rd, Saverio</au><au>Tarantal, Alice F</au><au>Osorio, Jorge E</au><au>O'Connor, Shelby L</au><au>Friedrich, Thomas C</au><au>O'Connor, David H</au><au>Golos, Thaddeus G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques</atitle><jtitle>PLoS pathogens</jtitle><addtitle>PLoS Pathog</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>13</volume><issue>5</issue><spage>e1006378</spage><epage>e1006378</epage><pages>e1006378-e1006378</pages><issn>1553-7374</issn><issn>1553-7366</issn><eissn>1553-7374</eissn><abstract>Infection with Zika virus (ZIKV) is associated with human congenital fetal anomalies. To model fetal outcomes in nonhuman primates, we administered Asian-lineage ZIKV subcutaneously to four pregnant rhesus macaques. While non-pregnant animals in a previous study contemporary with the current report clear viremia within 10-12 days, maternal viremia was prolonged in 3 of 4 pregnancies. Fetal head growth velocity in the last month of gestation determined by ultrasound assessment of head circumference was decreased in comparison with biparietal diameter and femur length within each fetus, both within normal range. ZIKV RNA was detected in tissues from all four fetuses at term cesarean section. In all pregnancies, neutrophilic infiltration was present at the maternal-fetal interface (decidua, placenta, fetal membranes), in various fetal tissues, and in fetal retina, choroid, and optic nerve (first trimester infection only). Consistent vertical transmission in this primate model may provide a platform to assess risk factors and test therapeutic interventions for interruption of fetal infection. The results may also suggest that maternal-fetal ZIKV transmission in human pregnancy may be more frequent than currently appreciated.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28542585</pmid><doi>10.1371/journal.ppat.1006378</doi><orcidid>https://orcid.org/0000-0002-4037-5486</orcidid><orcidid>https://orcid.org/0000-0003-2139-470X</orcidid><orcidid>https://orcid.org/0000-0002-7931-1930</orcidid><orcidid>https://orcid.org/0000-0002-2213-9332</orcidid><orcidid>https://orcid.org/0000-0002-1354-7078</orcidid><orcidid>https://orcid.org/0000-0001-9831-6895</orcidid><orcidid>https://orcid.org/0000-0003-0418-8816</orcidid><orcidid>https://orcid.org/0000-0001-9960-678X</orcidid><orcidid>https://orcid.org/0000-0003-3537-8030</orcidid><orcidid>https://orcid.org/0000-0002-8660-0853</orcidid><orcidid>https://orcid.org/0000-0002-8436-2820</orcidid><orcidid>https://orcid.org/0000-0002-6902-9149</orcidid><orcidid>https://orcid.org/0000-0002-1731-9806</orcidid><orcidid>https://orcid.org/0000-0002-7897-4337</orcidid><orcidid>https://orcid.org/0000-0002-8453-7256</orcidid><orcidid>https://orcid.org/0000-0003-0742-305X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1553-7374 |
| ispartof | PLoS pathogens, 2017-05, Vol.13 (5), p.e1006378-e1006378 |
| issn | 1553-7374 1553-7366 1553-7374 |
| language | eng |
| recordid | cdi_plos_journals_1910461982 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Amniotic Fluid - virology Animals Anomalies Biology and life sciences Cesarean section Cytomegalovirus Decidua Decidua - pathology Decidua - virology Disease Models, Animal Disease transmission Diseases and pests Distribution Female Femur Fetal Development Fetus Fetuses Gestation Gynecology Health aspects Humans Infections Infectious Disease Transmission, Vertical Infiltration Laboratories Leukocytes (neutrophilic) Listeria Lung - pathology Lung - virology Macaca mulatta Medicine Medicine and Health Sciences Membranes Monkeys & apes Obstetrics Optic nerve Pathology Pediatrics Physiological aspects Placenta Placenta - pathology Placenta - virology Pregnancy Pregnancy Complications, Infectious Primates Research and Analysis Methods Retina Ribonucleic acid Risk analysis Risk factors RNA RNA, Viral - analysis Spleen - pathology Spleen - virology Therapeutic applications Tissues Ultrasonic imaging Ultrasound Umbilical Cord - pathology Umbilical Cord - virology Vaccines Vector-borne diseases Velocity Viremia Viruses Zika virus Zika Virus - physiology Zika Virus Infection - pathology Zika Virus Infection - transmission Zika Virus Infection - virology |
| title | Highly efficient maternal-fetal Zika virus transmission in pregnant rhesus macaques |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A27%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Highly%20efficient%20maternal-fetal%20Zika%20virus%20transmission%20in%20pregnant%20rhesus%20macaques&rft.jtitle=PLoS%20pathogens&rft.au=Nguyen,%20Sydney%20M&rft.date=2017-05-01&rft.volume=13&rft.issue=5&rft.spage=e1006378&rft.epage=e1006378&rft.pages=e1006378-e1006378&rft.issn=1553-7374&rft.eissn=1553-7374&rft_id=info:doi/10.1371/journal.ppat.1006378&rft_dat=%3Cgale_plos_%3EA493733511%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1910461982&rft_id=info:pmid/28542585&rft_galeid=A493733511&rft_doaj_id=oai_doaj_org_article_c7d96184abee40dd90777c869ba3f514&rfr_iscdi=true |