A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host

The process by which drug-resistant HIV-1 arises and spreads spatially within an infected individual is poorly understood. Studies have found variable results relating how HIV-1 in the blood differs from virus sampled in tissues, offering conflicting findings about whether HIV-1 throughout the body...

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Veröffentlicht in:	PLoS pathogens 2017-05, Vol.13 (5), p.e1006358
Hauptverfasser:	Feder, Alison F, Kline, Christopher, Polacino, Patricia, Cottrell, Mackenzie, Kashuba, Angela D M, Keele, Brandon F, Hu, Shiu-Lok, Petrov, Dmitri A, Pennings, Pleuni S, Ambrose, Zandrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals Antimicrobial agents Balancing Biology and life sciences Biomedical research Blood Cancer therapies Coding Compartments Deoxyribonucleic acid Digestive tract DNA DNA, Viral - blood Drug resistance Drug Resistance, Viral Drug therapy Dynamics Emergence Evolution Female Gastrointestinal tract Gastrointestinal Tract - virology Gene sequencing Genetic aspects Genomes Genotypes HIV HIV Infections - virology HIV Reverse Transcriptase - genetics HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus Humans Hypothesis testing Infectious diseases Inhibitors Leukocytes, Mononuclear Lymph nodes Lymph Nodes - virology Lymphatic system Macaca mulatta Medical research Medicine Medicine and Health Sciences Migration Mitochondrial DNA Molecular biology Mucosa Mutation Organ Specificity Peripheral blood mononuclear cells Pharmacy Phylogenetics Physiological aspects Plasma Reverse Transcriptase Inhibitors - therapeutic use Ribonucleic acid RNA RNA, Viral - blood RNA-directed DNA polymerase Simian Acquired Immunodeficiency Syndrome - virology Simian immunodeficiency virus Simian Immunodeficiency Virus - genetics Simian Immunodeficiency Virus - physiology Spatial distribution Studies Time measurement Tissues Vagina Vagina - virology Viremia Viruses
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