Successful treatment of 2 imported cases of Mansonella perstans infection
About the Authors: Hilmir Asgeirsson * E-mail: hilmir.asgeirsson@sll.se Affiliations Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden, Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden ORCID http://orcid.org/000...
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| description | About the Authors: Hilmir Asgeirsson * E-mail: hilmir.asgeirsson@sll.se Affiliations Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden, Unit of Infectious Diseases, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden ORCID http://orcid.org/0000-0003-3869-8021 Andreas Harling Affiliation: Department of Infectious Diseases, Karlstad Central Hospital, Karlstad, Sweden Silvia Botero-Kleiven Affiliation: Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, SwedenCitation: Asgeirsson H, Harling A, Botero-Kleiven S (2017) Successful treatment of 2 imported cases of Mansonella perstans infection. After the discovery of the symbiotic bacteria Wolbachia in M. perstans strains from certain endemic regions, doxycycline has, however, emerged as a promising treatment alternative [11, 12]. The white blood cell count was 37.3 x 109/L, with eosinophils 24.8 x 109/L. Bone marrow biopsy revealed a cell-rich marrow with high-grade eosinophilia, without suspicion of malignancy. Filaria serology (in-house ELISA based on cross-reaction of antibodies directed against common Acanthocheilonema vitae antigens) was strongly positive (209 arbitrary units, cutoff 17), while for Strongyloides, optical density (OD) of 1.5 units (cutoff 0.5) was a suspected cross-reaction. [...]analysis revealed M. perstans 83 microfilariae/ml and Loa loa 670 microfilariae/ml peripheral blood (membrane filtration technique). [...]hypersensitivity reaction, possibly severe, with eosinophilia may be a manifestation of M. perstans infection in travelers and migrants coming from endemic areas. Key learning points * M. perstans infection commonly presents with unspecific symptoms. * M. perstans infection may present as hypersensitivity reaction, possibly severe, with eosinophilia in travelers and migrants coming from endemic areas. * Antihelminthic treatment regimens including doxycycline may be effective in clearing M. perstans... |
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After the discovery of the symbiotic bacteria Wolbachia in M. perstans strains from certain endemic regions, doxycycline has, however, emerged as a promising treatment alternative [11, 12]. The white blood cell count was 37.3 x 109/L, with eosinophils 24.8 x 109/L. Bone marrow biopsy revealed a cell-rich marrow with high-grade eosinophilia, without suspicion of malignancy. Filaria serology (in-house ELISA based on cross-reaction of antibodies directed against common Acanthocheilonema vitae antigens) was strongly positive (209 arbitrary units, cutoff 17), while for Strongyloides, optical density (OD) of 1.5 units (cutoff 0.5) was a suspected cross-reaction. [...]analysis revealed M. perstans 83 microfilariae/ml and Loa loa 670 microfilariae/ml peripheral blood (membrane filtration technique). [...]hypersensitivity reaction, possibly severe, with eosinophilia may be a manifestation of M. perstans infection in travelers and migrants coming from endemic areas. Key learning points * M. perstans infection commonly presents with unspecific symptoms. * M. perstans infection may present as hypersensitivity reaction, possibly severe, with eosinophilia in travelers and migrants coming from endemic areas. * Antihelminthic treatment regimens including doxycycline may be effective in clearing M. perstans...</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0005452</identifier><identifier>PMID: 28542192</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adult ; Albendazole ; Albendazole - administration & dosage ; Albendazole - therapeutic use ; Animals ; Anthelmintic agents ; Anthelmintics - administration & dosage ; Anthelmintics - therapeutic use ; Antibodies ; Antigens ; Antihelminthic agents ; Antineutrophil cytoplasmic antibodies ; Bacteria ; Benzimidazole ; Benzimidazoles ; Biology and Life Sciences ; Biopsy ; Biting ; Blood ; Blood cells ; Blood diseases ; Bone marrow ; Care and treatment ; CAT scans ; Computed tomography ; Diagnosis ; Doxycycline - administration & dosage ; Doxycycline - therapeutic use ; Drug dosages ; Drug Therapy, Combination ; Fatigue ; Fatigue tests ; Female ; Fever ; Filtration ; Funding ; Health aspects ; Heart ; Hospitals ; Humans ; Hypersensitivity ; Immunoglobulin E ; Infections ; Infectious diseases ; Ivermectin - administration & dosage ; Ivermectin - therapeutic use ; Malaria ; Male ; Malignancy ; Mansonella ; Mansonelliasis - drug therapy ; Mansonelliasis - epidemiology ; Medicine and Health Sciences ; Membrane filtration ; Microbiology ; Microscopy ; Middle Aged ; Migration ; Nuclei ; Pain ; Parasites ; Parasitic diseases ; Pathogens ; Prednisolone - administration & dosage ; Prednisolone - therapeutic use ; Quality ; Respiration ; Roundworm infections ; Roundworms ; Social Sciences ; Symposium ; Travel ; Tropical diseases ; Urine</subject><ispartof>PLoS neglected tropical diseases, 2017-05, Vol.11 (5), p.e0005452-e0005452</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: infection. PLoS Negl Trop Dis 11(5): e0005452. https://doi.org/10.1371/journal.pntd.0005452</rights><rights>2017 Asgeirsson et al 2017 Asgeirsson et al</rights><rights>2017 Public Library of Science. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited: infection. 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After the discovery of the symbiotic bacteria Wolbachia in M. perstans strains from certain endemic regions, doxycycline has, however, emerged as a promising treatment alternative [11, 12]. The white blood cell count was 37.3 x 109/L, with eosinophils 24.8 x 109/L. Bone marrow biopsy revealed a cell-rich marrow with high-grade eosinophilia, without suspicion of malignancy. Filaria serology (in-house ELISA based on cross-reaction of antibodies directed against common Acanthocheilonema vitae antigens) was strongly positive (209 arbitrary units, cutoff 17), while for Strongyloides, optical density (OD) of 1.5 units (cutoff 0.5) was a suspected cross-reaction. [...]analysis revealed M. perstans 83 microfilariae/ml and Loa loa 670 microfilariae/ml peripheral blood (membrane filtration technique). [...]hypersensitivity reaction, possibly severe, with eosinophilia may be a manifestation of M. perstans infection in travelers and migrants coming from endemic areas. Key learning points * M. perstans infection commonly presents with unspecific symptoms. * M. perstans infection may present as hypersensitivity reaction, possibly severe, with eosinophilia in travelers and migrants coming from endemic areas. * Antihelminthic treatment regimens including doxycycline may be effective in clearing M. perstans...</description><subject>Abdomen</subject><subject>Adult</subject><subject>Albendazole</subject><subject>Albendazole - administration & dosage</subject><subject>Albendazole - therapeutic use</subject><subject>Animals</subject><subject>Anthelmintic agents</subject><subject>Anthelmintics - administration & dosage</subject><subject>Anthelmintics - therapeutic use</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Antihelminthic agents</subject><subject>Antineutrophil cytoplasmic antibodies</subject><subject>Bacteria</subject><subject>Benzimidazole</subject><subject>Benzimidazoles</subject><subject>Biology and Life Sciences</subject><subject>Biopsy</subject><subject>Biting</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Blood diseases</subject><subject>Bone marrow</subject><subject>Care and treatment</subject><subject>CAT scans</subject><subject>Computed tomography</subject><subject>Diagnosis</subject><subject>Doxycycline - administration & dosage</subject><subject>Doxycycline - therapeutic use</subject><subject>Drug dosages</subject><subject>Drug Therapy, Combination</subject><subject>Fatigue</subject><subject>Fatigue tests</subject><subject>Female</subject><subject>Fever</subject><subject>Filtration</subject><subject>Funding</subject><subject>Health aspects</subject><subject>Heart</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Immunoglobulin E</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Ivermectin - administration & dosage</subject><subject>Ivermectin - therapeutic use</subject><subject>Malaria</subject><subject>Male</subject><subject>Malignancy</subject><subject>Mansonella</subject><subject>Mansonelliasis - drug therapy</subject><subject>Mansonelliasis - epidemiology</subject><subject>Medicine and Health Sciences</subject><subject>Membrane filtration</subject><subject>Microbiology</subject><subject>Microscopy</subject><subject>Middle Aged</subject><subject>Migration</subject><subject>Nuclei</subject><subject>Pain</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Pathogens</subject><subject>Prednisolone - 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After the discovery of the symbiotic bacteria Wolbachia in M. perstans strains from certain endemic regions, doxycycline has, however, emerged as a promising treatment alternative [11, 12]. The white blood cell count was 37.3 x 109/L, with eosinophils 24.8 x 109/L. Bone marrow biopsy revealed a cell-rich marrow with high-grade eosinophilia, without suspicion of malignancy. Filaria serology (in-house ELISA based on cross-reaction of antibodies directed against common Acanthocheilonema vitae antigens) was strongly positive (209 arbitrary units, cutoff 17), while for Strongyloides, optical density (OD) of 1.5 units (cutoff 0.5) was a suspected cross-reaction. [...]analysis revealed M. perstans 83 microfilariae/ml and Loa loa 670 microfilariae/ml peripheral blood (membrane filtration technique). [...]hypersensitivity reaction, possibly severe, with eosinophilia may be a manifestation of M. perstans infection in travelers and migrants coming from endemic areas. Key learning points * M. perstans infection commonly presents with unspecific symptoms. * M. perstans infection may present as hypersensitivity reaction, possibly severe, with eosinophilia in travelers and migrants coming from endemic areas. * Antihelminthic treatment regimens including doxycycline may be effective in clearing M. perstans...</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28542192</pmid><doi>10.1371/journal.pntd.0005452</doi><orcidid>https://orcid.org/0000-0003-3869-8021</orcidid><oa>free_for_read</oa></addata></record> |
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| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_1910461687 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; SWEPUB Freely available online; PubMed Central Open Access; Public Library of Science (PLoS) |
| subjects | Abdomen Adult Albendazole Albendazole - administration & dosage Albendazole - therapeutic use Animals Anthelmintic agents Anthelmintics - administration & dosage Anthelmintics - therapeutic use Antibodies Antigens Antihelminthic agents Antineutrophil cytoplasmic antibodies Bacteria Benzimidazole Benzimidazoles Biology and Life Sciences Biopsy Biting Blood Blood cells Blood diseases Bone marrow Care and treatment CAT scans Computed tomography Diagnosis Doxycycline - administration & dosage Doxycycline - therapeutic use Drug dosages Drug Therapy, Combination Fatigue Fatigue tests Female Fever Filtration Funding Health aspects Heart Hospitals Humans Hypersensitivity Immunoglobulin E Infections Infectious diseases Ivermectin - administration & dosage Ivermectin - therapeutic use Malaria Male Malignancy Mansonella Mansonelliasis - drug therapy Mansonelliasis - epidemiology Medicine and Health Sciences Membrane filtration Microbiology Microscopy Middle Aged Migration Nuclei Pain Parasites Parasitic diseases Pathogens Prednisolone - administration & dosage Prednisolone - therapeutic use Quality Respiration Roundworm infections Roundworms Social Sciences Symposium Travel Tropical diseases Urine |
| title | Successful treatment of 2 imported cases of Mansonella perstans infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-16T08%3A49%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Successful%20treatment%20of%202%20imported%20cases%20of%20Mansonella%20perstans%20infection&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Asgeirsson,%20Hilmir&rft.date=2017-05-25&rft.volume=11&rft.issue=5&rft.spage=e0005452&rft.epage=e0005452&rft.pages=e0005452-e0005452&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0005452&rft_dat=%3Cgale_plos_%3EA493733445%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1910461687&rft_id=info:pmid/28542192&rft_galeid=A493733445&rft_doaj_id=oai_doaj_org_article_084e4ab107c246c6bee2ec654f5435d2&rfr_iscdi=true |