Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants

The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. Many viruses, including MERS-CoV and the Crimean-Con...

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Veröffentlicht in:	PLoS pathogens 2017-05, Vol.13 (5), p.e1006372-e1006372
Hauptverfasser:	Zhang, Wei, Bailey-Elkin, Ben A, Knaap, Robert C M, Khare, Baldeep, Dalebout, Tim J, Johnson, Garrett G, van Kasteren, Puck B, McLeish, Nigel J, Gu, Jun, He, Wenguang, Kikkert, Marjolein, Mark, Brian L, Sidhu, Sachdev S
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Binding Biology and life sciences Catalysis Colleges & universities Cores Coronaviridae Coronavirus Infections - metabolism Coronavirus Infections - virology Coronaviruses Crimean hemorrhagic fever Critical components Crystallization Design engineering Development and progression Drug Evaluation, Preclinical Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Fever Gene expression Genetic aspects Genetics Health Hemorrhage Hemorrhagic Fever Virus, Crimean-Congo - drug effects Hemorrhagic Fever Virus, Crimean-Congo - enzymology Hemorrhagic Fever Virus, Crimean-Congo - genetics Hemorrhagic Fever, Crimean - metabolism Hemorrhagic Fever, Crimean - virology Humans Immune response Infections Infectious diseases Inhibition Inhibitors Innate immunity Interferon Libraries Medical research Medicine and Health Sciences Middle East Respiratory Syndrome Coronavirus - drug effects Middle East Respiratory Syndrome Coronavirus - enzymology Middle East Respiratory Syndrome Coronavirus - genetics Molecular interactions mRNA Offspring Outbreaks Papain Pathogenicity Pathogens Phages Physiological aspects Polyproteins Progeny Protease Proteinase Proteins Replicase Replication Research and Analysis Methods Respiratory diseases Similarity Ubiquitin Ubiquitin - metabolism Ubiquitination - drug effects Vector-borne diseases Viral diseases Viral Proteins - antagonists & inhibitors Viral Proteins - chemistry Viral Proteins - genetics Viral Proteins - metabolism Virus diseases Viruses
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