Hepatitis E virus persists in the presence of a type III interferon response

The RIG-I-like RNA helicase (RLR)-mediated interferon (IFN) response plays a pivotal role in the hepatic antiviral immunity. The hepatitis A virus (HAV) and the hepatitis C virus (HCV) counter this response by encoding a viral protease that cleaves the mitochondria antiviral signaling protein (MAVS)...

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Veröffentlicht in:	PLoS pathogens 2017-05, Vol.13 (5), p.e1006417-e1006417
Hauptverfasser:	Yin, Xin, Li, Xinlei, Ambardekar, Charuta, Hu, Zhimin, Lhomme, Sébastien, Feng, Zongdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Biology and life sciences Coding Continuous production DEAD-box RNA Helicases - genetics DEAD-box RNA Helicases - immunology Depletion Development and progression DNA helicase Functional anatomy Gene expression Genes Genetic aspects Genetic engineering Genotype & phenotype Health aspects Hepatitis Hepatitis A Hepatitis C Hepatitis E Hepatitis E - genetics Hepatitis E - immunology Hepatitis E - virology Hepatitis E virus - genetics Hepatitis E virus - immunology Hepatitis E virus - physiology Hepatocytes Hepatocytes - immunology Hepatocytes - virology Hepatoma Hospitals Humans Immunity Infections Interferon Interferons - genetics Interferons - immunology Kinases Liver Liver diseases Localization Medicine and health sciences Mitochondria Physiological aspects Protease Proteinase Proteins Replication Research and Analysis Methods Ribonucleic acid RNA RNA helicase RNA viruses Transcription Virology Virus Replication Viruses
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