Oligodendroglial myelination requires astrocyte-derived lipids

In the vertebrate nervous system, myelination of axons for rapid impulse propagation requires the synthesis of large amounts of lipids and proteins by oligodendrocytes and Schwann cells. Myelin membranes are thought to be cell-autonomously assembled by these axon-associated glial cells. Here, we rep...

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Veröffentlicht in:	PLoS biology 2017-05, Vol.15 (5), p.e1002605-e1002605
Hauptverfasser:	Camargo, Nutabi, Goudriaan, Andrea, van Deijk, Anne-Lieke F, Otte, Willem M, Brouwers, Jos F, Lodder, Hans, Gutmann, David H, Nave, Klaus-Armin, Dijkhuizen, Rick M, Mansvelder, Huibert D, Chrast, Roman, Smit, August B, Verheijen, Mark H G
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Animals Astrocytes Astrocytes - metabolism Astrocytes - pathology Astrocytes - ultrastructure Axons Biology and Life Sciences Biomarkers - metabolism Biosynthesis Brain Brain research Central nervous system Cleavage Clonal deletion Crosses, Genetic Deactivation Demyelinating Diseases - metabolism Demyelinating Diseases - pathology Demyelinating Diseases - prevention & control Developmental biology Diet, High-Fat Embryos Enrichment Fatty Acid Synthase, Type I - metabolism Fluctuations Flux Gene Deletion Glial cells Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Humans Inactivation Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Lipid Metabolism Lipids Medicine and Health Sciences Membrane Proteins - genetics Membrane Proteins - metabolism Membranes Mice, Inbred C57BL Mice, Transgenic Microscopy, Electron, Transmission Mutants Mutation Myelin Myelin Sheath - metabolism Myelin Sheath - pathology Myelin Sheath - ultrastructure Myelination Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous system Neurobiology Neurons Observations Oligodendrocytes Oligodendroglia - metabolism Oligodendroglia - pathology Oligodendroglia - ultrastructure Organ Specificity Physical Sciences Physiological aspects Propagation Protein Processing, Post-Translational Proteins Schwann cells Sterol Regulatory Element Binding Protein 2 - genetics Sterol Regulatory Element Binding Protein 2 - metabolism Sterol regulatory element-binding protein
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