Effect of previous and current vaccination against influenza A(H1N1)pdm09, A(H3N2), and B during the post-pandemic period 2010-2016 in Spain
Recent studies suggest that the protective effect of the current influenza vaccine could be influenced by vaccination in previous seasons. We estimated the combined effect of the previous and current influenza vaccines from the 2010-2011 season to the 2015-2016 season in Spain. We performed a test-n...
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| Veröffentlicht in: | PloS one 2017-06, Vol.12 (6), p.e0179160 |
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| creator | Gherasim, Alin Martínez-Baz, Iván Castilla, Jesús Pozo, Francisco Larrauri, Amparo |
| description | Recent studies suggest that the protective effect of the current influenza vaccine could be influenced by vaccination in previous seasons. We estimated the combined effect of the previous and current influenza vaccines from the 2010-2011 season to the 2015-2016 season in Spain.
We performed a test-negative case-control study in patients ≥9 years old. We estimated the influenza vaccine effectiveness (IVE) against influenza A(H1N1)pdm09, A(H3N2), and B virus.
We included 1206 influenza A(H1N1)pdm09 cases, 1358 A(H3N2) cases and 1079 B cases. IVE against A(H1N1)pdm09 virus in the pooled-season analysis was 53% (95% Confidence Interval (CI): 21% to 72%) for those vaccinated only in the current season and 50% (95%CI: 23% to 68%) for those vaccinated in the both current and previous seasons. Against the influenza A(H3N2) virus, IVE was 17% (95%CI: -43% to 52%) for those vaccinated only in the current season and 3% (95%CI: -33% to 28%) for those vaccinated in both seasons. Regarding influenza B, we obtained similar IVEs for those vaccinated only in the current and those vaccinated in both seasons: 57% (95%CI: 12% to 79%) and 56% (95%CI: 36% to 70%), respectively.
Our results suggested no interference between the previous and current influenza vaccines against A(H1N1)pdm09 and B viruses, but a possible negative interference against A(H3N2) virus. |
| doi_str_mv | 10.1371/journal.pone.0179160 |
| format | Article |
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We performed a test-negative case-control study in patients ≥9 years old. We estimated the influenza vaccine effectiveness (IVE) against influenza A(H1N1)pdm09, A(H3N2), and B virus.
We included 1206 influenza A(H1N1)pdm09 cases, 1358 A(H3N2) cases and 1079 B cases. IVE against A(H1N1)pdm09 virus in the pooled-season analysis was 53% (95% Confidence Interval (CI): 21% to 72%) for those vaccinated only in the current season and 50% (95%CI: 23% to 68%) for those vaccinated in the both current and previous seasons. Against the influenza A(H3N2) virus, IVE was 17% (95%CI: -43% to 52%) for those vaccinated only in the current season and 3% (95%CI: -33% to 28%) for those vaccinated in both seasons. Regarding influenza B, we obtained similar IVEs for those vaccinated only in the current and those vaccinated in both seasons: 57% (95%CI: 12% to 79%) and 56% (95%CI: 36% to 70%), respectively.
Our results suggested no interference between the previous and current influenza vaccines against A(H1N1)pdm09 and B viruses, but a possible negative interference against A(H3N2) virus.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0179160</identifier><identifier>PMID: 28614376</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Biology and Life Sciences ; Case-Control Studies ; Child ; Chronic illnesses ; Combined vaccines ; Confidence intervals ; Epidemiology ; Estimates ; Female ; Health surveillance ; Humans ; Immunization ; Influenza ; Influenza A ; Influenza A Virus, H1N1 Subtype - drug effects ; Influenza A Virus, H3N2 Subtype - drug effects ; Influenza B ; Influenza B virus - drug effects ; Influenza Vaccines - pharmacology ; Influenza Vaccines - therapeutic use ; Influenza, Human - epidemiology ; Influenza, Human - prevention & control ; Interference ; Male ; Medical research ; Medicine and Health Sciences ; Middle Aged ; Pandemics ; Patients ; People and Places ; Physical Sciences ; Public health ; Seasons ; Sentinel Surveillance ; Spain ; Studies ; Vaccine efficacy ; Vaccines ; Viruses ; Working groups ; Young Adult</subject><ispartof>PloS one, 2017-06, Vol.12 (6), p.e0179160</ispartof><rights>2017 Gherasim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Gherasim et al 2017 Gherasim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-531458688b5e60409f9b7a044182926cfd5940f0db3b226d005901261d8660813</citedby><cites>FETCH-LOGICAL-c526t-531458688b5e60409f9b7a044182926cfd5940f0db3b226d005901261d8660813</cites><orcidid>0000-0002-1704-2245</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470701/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470701/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28614376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gherasim, Alin</creatorcontrib><creatorcontrib>Martínez-Baz, Iván</creatorcontrib><creatorcontrib>Castilla, Jesús</creatorcontrib><creatorcontrib>Pozo, Francisco</creatorcontrib><creatorcontrib>Larrauri, Amparo</creatorcontrib><creatorcontrib>cycEVA working group</creatorcontrib><creatorcontrib>the cycEVA working group</creatorcontrib><title>Effect of previous and current vaccination against influenza A(H1N1)pdm09, A(H3N2), and B during the post-pandemic period 2010-2016 in Spain</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Recent studies suggest that the protective effect of the current influenza vaccine could be influenced by vaccination in previous seasons. We estimated the combined effect of the previous and current influenza vaccines from the 2010-2011 season to the 2015-2016 season in Spain.
We performed a test-negative case-control study in patients ≥9 years old. We estimated the influenza vaccine effectiveness (IVE) against influenza A(H1N1)pdm09, A(H3N2), and B virus.
We included 1206 influenza A(H1N1)pdm09 cases, 1358 A(H3N2) cases and 1079 B cases. IVE against A(H1N1)pdm09 virus in the pooled-season analysis was 53% (95% Confidence Interval (CI): 21% to 72%) for those vaccinated only in the current season and 50% (95%CI: 23% to 68%) for those vaccinated in the both current and previous seasons. Against the influenza A(H3N2) virus, IVE was 17% (95%CI: -43% to 52%) for those vaccinated only in the current season and 3% (95%CI: -33% to 28%) for those vaccinated in both seasons. Regarding influenza B, we obtained similar IVEs for those vaccinated only in the current and those vaccinated in both seasons: 57% (95%CI: 12% to 79%) and 56% (95%CI: 36% to 70%), respectively.
Our results suggested no interference between the previous and current influenza vaccines against A(H1N1)pdm09 and B viruses, but a possible negative interference against A(H3N2) virus.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biology and Life Sciences</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Chronic illnesses</subject><subject>Combined vaccines</subject><subject>Confidence intervals</subject><subject>Epidemiology</subject><subject>Estimates</subject><subject>Female</subject><subject>Health surveillance</subject><subject>Humans</subject><subject>Immunization</subject><subject>Influenza</subject><subject>Influenza A</subject><subject>Influenza A Virus, H1N1 Subtype - drug effects</subject><subject>Influenza A Virus, H3N2 Subtype - drug effects</subject><subject>Influenza B</subject><subject>Influenza B virus - drug effects</subject><subject>Influenza Vaccines - pharmacology</subject><subject>Influenza Vaccines - therapeutic use</subject><subject>Influenza, Human - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gherasim, Alin</au><au>Martínez-Baz, Iván</au><au>Castilla, Jesús</au><au>Pozo, Francisco</au><au>Larrauri, Amparo</au><aucorp>cycEVA working group</aucorp><aucorp>the cycEVA working group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of previous and current vaccination against influenza A(H1N1)pdm09, A(H3N2), and B during the post-pandemic period 2010-2016 in Spain</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-06-14</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>e0179160</spage><pages>e0179160-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Recent studies suggest that the protective effect of the current influenza vaccine could be influenced by vaccination in previous seasons. We estimated the combined effect of the previous and current influenza vaccines from the 2010-2011 season to the 2015-2016 season in Spain.
We performed a test-negative case-control study in patients ≥9 years old. We estimated the influenza vaccine effectiveness (IVE) against influenza A(H1N1)pdm09, A(H3N2), and B virus.
We included 1206 influenza A(H1N1)pdm09 cases, 1358 A(H3N2) cases and 1079 B cases. IVE against A(H1N1)pdm09 virus in the pooled-season analysis was 53% (95% Confidence Interval (CI): 21% to 72%) for those vaccinated only in the current season and 50% (95%CI: 23% to 68%) for those vaccinated in the both current and previous seasons. Against the influenza A(H3N2) virus, IVE was 17% (95%CI: -43% to 52%) for those vaccinated only in the current season and 3% (95%CI: -33% to 28%) for those vaccinated in both seasons. Regarding influenza B, we obtained similar IVEs for those vaccinated only in the current and those vaccinated in both seasons: 57% (95%CI: 12% to 79%) and 56% (95%CI: 36% to 70%), respectively.
Our results suggested no interference between the previous and current influenza vaccines against A(H1N1)pdm09 and B viruses, but a possible negative interference against A(H3N2) virus.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28614376</pmid><doi>10.1371/journal.pone.0179160</doi><orcidid>https://orcid.org/0000-0002-1704-2245</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
| recordid | cdi_plos_journals_1909721843 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Biology and Life Sciences Case-Control Studies Child Chronic illnesses Combined vaccines Confidence intervals Epidemiology Estimates Female Health surveillance Humans Immunization Influenza Influenza A Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H3N2 Subtype - drug effects Influenza B Influenza B virus - drug effects Influenza Vaccines - pharmacology Influenza Vaccines - therapeutic use Influenza, Human - epidemiology Influenza, Human - prevention & control Interference Male Medical research Medicine and Health Sciences Middle Aged Pandemics Patients People and Places Physical Sciences Public health Seasons Sentinel Surveillance Spain Studies Vaccine efficacy Vaccines Viruses Working groups Young Adult |
| title | Effect of previous and current vaccination against influenza A(H1N1)pdm09, A(H3N2), and B during the post-pandemic period 2010-2016 in Spain |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T17%3A41%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20previous%20and%20current%20vaccination%20against%20influenza%20A(H1N1)pdm09,%20A(H3N2),%20and%20B%20during%20the%20post-pandemic%20period%202010-2016%20in%20Spain&rft.jtitle=PloS%20one&rft.au=Gherasim,%20Alin&rft.aucorp=cycEVA%20working%20group&rft.date=2017-06-14&rft.volume=12&rft.issue=6&rft.spage=e0179160&rft.pages=e0179160-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0179160&rft_dat=%3Cproquest_plos_%3E1910336069%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1909721843&rft_id=info:pmid/28614376&rft_doaj_id=oai_doaj_org_article_1ecdf1963fda4b3b8a8b28cfadeb2e01&rfr_iscdi=true |