$Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing$

Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing

The anaphylatoxin receptor C5aR1 plays an important role not only in innate immune responses, but also in bone metabolism and fracture healing, being highly expressed on immune and bone cells, including osteoblasts and osteoclasts. C5aR1 induces osteoblast migration, cytokine generation and osteocla...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0179512-e0179512
Hauptverfasser:	Bergdolt, Stephanie, Kovtun, Anna, Hägele, Yvonne, Liedert, Astrid, Schinke, Thorsten, Amling, Michael, Huber-Lang, Markus, Ignatius, Anita
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Analysis Animals Apoptosis Biocompatibility Biology and Life Sciences Biomechanics Biomedical materials Blotting, Western Bone density Bone healing Bone mineral density Bone regeneration Bone resorption Bone turnover Bones Bronchoalveolar Lavage Fluid - chemistry Bronchus Callus Care and treatment Cell proliferation Cells, Cultured Collagen (type I) Collagen Type I - genetics Collagen Type I - metabolism Complement Complement C5a - metabolism Complement component C5a Cytokines Differentiation Femur - diagnostic imaging Femur - metabolism Femur - surgery Fracture Healing - genetics Fractures (Injuries) Gene Expression Regulation Healing Immune response Immune system In vitro methods and tests Inflammation Innate immunity Interleukin 6 Interleukin-6 - genetics Interleukin-6 - metabolism Laboratory animals Leukocyte migration Medicine and Health Sciences Metabolism Mice Neutrophils Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - metabolism Osteoclastogenesis Osteoclasts Osteogenesis - genetics Osteoprotegerin Osteoprotegerin - genetics Osteoprotegerin - metabolism Osteotomy p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation RANK Ligand - genetics RANK Ligand - metabolism Receptor, Anaphylatoxin C5a - genetics Receptor, Anaphylatoxin C5a - metabolism Regeneration Regeneration (physiology) Research and Analysis Methods Reverse Transcriptase Polymerase Chain Reaction Rigidity Signal Transduction - genetics Spinal cord Thorax Trauma Up-Regulation X-Ray Microtomography - methods
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