Functional paralysis of GM-CSF-derived bone marrow cells productively infected with ectromelia virus

Ectromelia virus (ECTV) is an orthopoxvirus responsible for mousepox, a lethal disease of certain strains of mice that is similar to smallpox in humans, caused by variola virus (VARV). ECTV, similar to VARV, exhibits a narrow host range and has co-evolved with its natural host. Consequently, ECTV em...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0179166-e0179166
Hauptverfasser:	Szulc-Dąbrowska, Lidia, Struzik, Justyna, Ostrowska, Agnieszka, Guzera, Maciej, Toka, Felix N, Bossowska-Nowicka, Magdalena, Gieryńska, Małgorzata M, Winnicka, Anna, Nowak, Zuzanna, Niemiałtowski, Marek G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens - immunology Apoptosis Apoptosis - drug effects Biology and Life Sciences Bone marrow Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Bone Marrow Cells - virology CD4 antigen Cell activation Cell Line Cell proliferation Cells, Cultured Chemokines Colony-stimulating factor Cytokines Cytokines - metabolism Dendritic cells Disease Ectromelia Ectromelia virus - physiology Endocytosis - drug effects Endocytosis - immunology Functional anatomy Gene expression Gene regulation Genes Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Host range Immune response Immune system Immunophenotyping Immunosuppression Infections Inflammation Inhibition Interferon Interferon regulatory factor 3 Interferon regulatory factor 7 Interferon Type I - metabolism Leukocytes - immunology Leukocytes - metabolism Leukocytes - virology Life sciences Lymphocyte Activation - immunology Lymphocytes Lymphocytes T Macrophages Male Maturity Medicine and Health Sciences Mice Mixed leukocyte reaction Morphology Mortality Paralysis Proteins Signal Transduction Smallpox T-Lymphocytes - immunology T-Lymphocytes - metabolism Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - metabolism Transcription factors Translocation Tumor necrosis factor-TNF Vaccines Veterinary medicine Viral infections Virus Replication Viruses Zoonoses
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