Alterations in audiovisual simultaneity perception in amblyopia
Amblyopia is a developmental visual impairment that is increasingly recognized to affect higher-level perceptual and multisensory processes. To further investigate the audiovisual (AV) perceptual impairments associated with this condition, we characterized the temporal interval in which asynchronous...
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| description | Amblyopia is a developmental visual impairment that is increasingly recognized to affect higher-level perceptual and multisensory processes. To further investigate the audiovisual (AV) perceptual impairments associated with this condition, we characterized the temporal interval in which asynchronous auditory and visual stimuli are perceived as simultaneous 50% of the time (i.e., the AV simultaneity window). Adults with unilateral amblyopia (n = 17) and visually normal controls (n = 17) judged the simultaneity of a flash and a click presented with both eyes viewing. The signal onset asynchrony (SOA) varied from 0 ms to 450 ms for auditory-lead and visual-lead conditions. A subset of participants with amblyopia (n = 6) was tested monocularly. Compared to the control group, the auditory-lead side of the AV simultaneity window was widened by 48 ms (36%; p = 0.002), whereas that of the visual-lead side was widened by 86 ms (37%; p = 0.02). The overall mean window width was 500 ms, compared to 366 ms among controls (37% wider; p = 0.002). Among participants with amblyopia, the simultaneity window parameters were unchanged by viewing condition, but subgroup analysis revealed differential effects on the parameters by amblyopia severity, etiology, and foveal suppression status. Possible mechanisms to explain these findings include visual temporal uncertainty, interocular perceptual latency asymmetry, and disruption of normal developmental tuning of sensitivity to audiovisual asynchrony. |
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To further investigate the audiovisual (AV) perceptual impairments associated with this condition, we characterized the temporal interval in which asynchronous auditory and visual stimuli are perceived as simultaneous 50% of the time (i.e., the AV simultaneity window). Adults with unilateral amblyopia (n = 17) and visually normal controls (n = 17) judged the simultaneity of a flash and a click presented with both eyes viewing. The signal onset asynchrony (SOA) varied from 0 ms to 450 ms for auditory-lead and visual-lead conditions. A subset of participants with amblyopia (n = 6) was tested monocularly. Compared to the control group, the auditory-lead side of the AV simultaneity window was widened by 48 ms (36%; p = 0.002), whereas that of the visual-lead side was widened by 86 ms (37%; p = 0.02). The overall mean window width was 500 ms, compared to 366 ms among controls (37% wider; p = 0.002). Among participants with amblyopia, the simultaneity window parameters were unchanged by viewing condition, but subgroup analysis revealed differential effects on the parameters by amblyopia severity, etiology, and foveal suppression status. Possible mechanisms to explain these findings include visual temporal uncertainty, interocular perceptual latency asymmetry, and disruption of normal developmental tuning of sensitivity to audiovisual asynchrony.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0179516</identifier><identifier>PMID: 28598996</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acoustic Stimulation ; Adolescent ; Adult ; Adults ; Amblyopia ; Amblyopia - diagnosis ; Amblyopia - etiology ; Amblyopia - physiopathology ; Amblyopia - psychology ; Analysis ; Analysis of Variance ; Asymmetry ; Audio visual equipment ; Audiovisual equipment ; Auditory Perception ; Biology ; Biology and Life Sciences ; Care and treatment ; Depth Perception ; Development and progression ; Disruption ; Engineering and Technology ; Etiology ; Etiology (Medicine) ; Eye (anatomy) ; Female ; Hospitals ; Humans ; Impairment ; Latency ; Male ; Medical screening ; Medicine and Health Sciences ; Mental health ; Middle Aged ; Neurosciences ; Perception ; Perceptions ; Photic Stimulation ; Physical Sciences ; Physiological psychology ; Sensitivity ; Sensory integration ; Severity of Illness Index ; Social Sciences ; Speech ; Stimuli ; Tuning ; Uncertainty ; Viewing ; Vision, Binocular ; Vision, Monocular ; Visual Perception ; Visual stimuli ; Windows (intervals) ; Young Adult</subject><ispartof>PloS one, 2017-06, Vol.12 (6), p.e0179516-e0179516</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Richards et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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To further investigate the audiovisual (AV) perceptual impairments associated with this condition, we characterized the temporal interval in which asynchronous auditory and visual stimuli are perceived as simultaneous 50% of the time (i.e., the AV simultaneity window). Adults with unilateral amblyopia (n = 17) and visually normal controls (n = 17) judged the simultaneity of a flash and a click presented with both eyes viewing. The signal onset asynchrony (SOA) varied from 0 ms to 450 ms for auditory-lead and visual-lead conditions. A subset of participants with amblyopia (n = 6) was tested monocularly. Compared to the control group, the auditory-lead side of the AV simultaneity window was widened by 48 ms (36%; p = 0.002), whereas that of the visual-lead side was widened by 86 ms (37%; p = 0.02). The overall mean window width was 500 ms, compared to 366 ms among controls (37% wider; p = 0.002). Among participants with amblyopia, the simultaneity window parameters were unchanged by viewing condition, but subgroup analysis revealed differential effects on the parameters by amblyopia severity, etiology, and foveal suppression status. Possible mechanisms to explain these findings include visual temporal uncertainty, interocular perceptual latency asymmetry, and disruption of normal developmental tuning of sensitivity to audiovisual asynchrony.</description><subject>Acoustic Stimulation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Adults</subject><subject>Amblyopia</subject><subject>Amblyopia - diagnosis</subject><subject>Amblyopia - etiology</subject><subject>Amblyopia - physiopathology</subject><subject>Amblyopia - psychology</subject><subject>Analysis</subject><subject>Analysis of Variance</subject><subject>Asymmetry</subject><subject>Audio visual equipment</subject><subject>Audiovisual equipment</subject><subject>Auditory Perception</subject><subject>Biology</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Depth Perception</subject><subject>Development and progression</subject><subject>Disruption</subject><subject>Engineering and Technology</subject><subject>Etiology</subject><subject>Etiology (Medicine)</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Impairment</subject><subject>Latency</subject><subject>Male</subject><subject>Medical screening</subject><subject>Medicine and Health Sciences</subject><subject>Mental health</subject><subject>Middle Aged</subject><subject>Neurosciences</subject><subject>Perception</subject><subject>Perceptions</subject><subject>Photic Stimulation</subject><subject>Physical Sciences</subject><subject>Physiological psychology</subject><subject>Sensitivity</subject><subject>Sensory integration</subject><subject>Severity of Illness Index</subject><subject>Social Sciences</subject><subject>Speech</subject><subject>Stimuli</subject><subject>Tuning</subject><subject>Uncertainty</subject><subject>Viewing</subject><subject>Vision, Binocular</subject><subject>Vision, Monocular</subject><subject>Visual 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in audiovisual simultaneity perception in amblyopia</title><author>Richards, Michael D ; Goltz, Herbert C ; Wong, Agnes M F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-7eefff16bf518a813fea2fb4375b814d8490333c4c7133f3ec92dde01956bee03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acoustic Stimulation</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Adults</topic><topic>Amblyopia</topic><topic>Amblyopia - diagnosis</topic><topic>Amblyopia - etiology</topic><topic>Amblyopia - physiopathology</topic><topic>Amblyopia - psychology</topic><topic>Analysis</topic><topic>Analysis of Variance</topic><topic>Asymmetry</topic><topic>Audio visual equipment</topic><topic>Audiovisual equipment</topic><topic>Auditory Perception</topic><topic>Biology</topic><topic>Biology and Life Sciences</topic><topic>Care and treatment</topic><topic>Depth 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Perception</topic><topic>Visual stimuli</topic><topic>Windows (intervals)</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Richards, Michael D</creatorcontrib><creatorcontrib>Goltz, Herbert C</creatorcontrib><creatorcontrib>Wong, Agnes M F</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Richards, Michael D</au><au>Goltz, Herbert C</au><au>Wong, Agnes M F</au><au>Thompson, Benjamin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations in audiovisual simultaneity perception in amblyopia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-06-09</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>e0179516</spage><epage>e0179516</epage><pages>e0179516-e0179516</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Amblyopia is a developmental visual impairment that is increasingly recognized to affect higher-level perceptual and multisensory processes. To further investigate the audiovisual (AV) perceptual impairments associated with this condition, we characterized the temporal interval in which asynchronous auditory and visual stimuli are perceived as simultaneous 50% of the time (i.e., the AV simultaneity window). Adults with unilateral amblyopia (n = 17) and visually normal controls (n = 17) judged the simultaneity of a flash and a click presented with both eyes viewing. The signal onset asynchrony (SOA) varied from 0 ms to 450 ms for auditory-lead and visual-lead conditions. A subset of participants with amblyopia (n = 6) was tested monocularly. Compared to the control group, the auditory-lead side of the AV simultaneity window was widened by 48 ms (36%; p = 0.002), whereas that of the visual-lead side was widened by 86 ms (37%; p = 0.02). The overall mean window width was 500 ms, compared to 366 ms among controls (37% wider; p = 0.002). Among participants with amblyopia, the simultaneity window parameters were unchanged by viewing condition, but subgroup analysis revealed differential effects on the parameters by amblyopia severity, etiology, and foveal suppression status. Possible mechanisms to explain these findings include visual temporal uncertainty, interocular perceptual latency asymmetry, and disruption of normal developmental tuning of sensitivity to audiovisual asynchrony.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28598996</pmid><doi>10.1371/journal.pone.0179516</doi><tpages>e0179516</tpages><orcidid>https://orcid.org/0000-0002-1317-1082</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Acoustic Stimulation Adolescent Adult Adults Amblyopia Amblyopia - diagnosis Amblyopia - etiology Amblyopia - physiopathology Amblyopia - psychology Analysis Analysis of Variance Asymmetry Audio visual equipment Audiovisual equipment Auditory Perception Biology Biology and Life Sciences Care and treatment Depth Perception Development and progression Disruption Engineering and Technology Etiology Etiology (Medicine) Eye (anatomy) Female Hospitals Humans Impairment Latency Male Medical screening Medicine and Health Sciences Mental health Middle Aged Neurosciences Perception Perceptions Photic Stimulation Physical Sciences Physiological psychology Sensitivity Sensory integration Severity of Illness Index Social Sciences Speech Stimuli Tuning Uncertainty Viewing Vision, Binocular Vision, Monocular Visual Perception Visual stimuli Windows (intervals) Young Adult |
| title | Alterations in audiovisual simultaneity perception in amblyopia |
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