Hyperferritinemia and hypergammaglobulinemia predict the treatment response to standard therapy in autoimmune hepatitis

Autoimmune hepatitis (AIH) is a chronic hepatitis with an increasing incidence. The majority of patients require life-long immunosuppression and incomplete treatment response is associated with a disease progression. An abnormal iron homeostasis or hyperferritinemia is associated with worse outcome...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0179074-e0179074
Hauptverfasser:	Taubert, Richard, Hardtke-Wolenski, Matthias, Noyan, Fatih, Lalanne, Claudine, Jonigk, Danny, Schlue, Jerome, Krech, Till, Lichtinghagen, Ralf, Falk, Christine S, Schlaphoff, Verena, Bantel, Heike, Muratori, Luigi, Manns, Michael P, Jaeckel, Elmar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Area Under Curve Bacterial infections Biochemistry Biology and Life Sciences Biopsy Care and treatment Chronic active hepatitis Cohort Studies Cytokines Damage Deregulation Diagnostic systems Diseases Dosage and administration Endocrinology Ferritin Ferritins - blood Gastroenterology Gene expression Growth factors Hepatitis Hepatitis, Autoimmune - blood Hepatitis, Autoimmune - complications Hepatitis, Autoimmune - therapy Hepatocyte growth factor Hepatocyte Growth Factor - pharmacology Hepatology Hepcidin Hepcidins - metabolism Histology Homeostasis Humans Hypergammaglobulinemia Hypergammaglobulinemia - blood Hypergammaglobulinemia - complications Hypotheses Hypotheses (Scientific method) Immunoglobulins Immunosuppression Immunosuppressive agents Incidence Infections Iron Laboratories Liver Liver diseases Liver transplantation Medical prognosis Medical schools Medicine and Health Sciences Metabolism Mice Pathology Patients Reference Standards Remission Remission Induction ROC Curve Therapy Training Transferrin Transferrins Transplantation Transplants & implants Treatment Outcome
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