Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease

Loss of Norrin signalling due to mutations in the Norrie disease pseudoglioma gene causes severe vascular defects in the retina, leading to visual impairment and ultimately blindness. While the emphasis of experimental work so far was on the developmental period, we focus here on disease mechanisms...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0178753
Hauptverfasser:	Beck, Susanne C, Feng, Yuxi, Sothilingam, Vithiyanjali, Garcia Garrido, Marina, Tanimoto, Naoyuki, Acar, Niyazi, Shan, Shenliang, Seebauer, Britta, Berger, Wolfgang, Hammes, Hans-Peter, Seeliger, Mathias W
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities Angiogenesis Angiography Animals Biology and Life Sciences Blindness Blindness - congenital Blindness - diagnostic imaging Blindness - genetics Blindness - pathology Capillaries - pathology Cell Hypoxia Complications and side effects Defects Diabetes Diabetic retinopathy Disease Disease Models, Animal Disease Progression Electroretinography Eye Proteins - genetics Eye Proteins - physiology Functional anatomy Genetic Diseases, X-Linked - diagnostic imaging Genetic Diseases, X-Linked - genetics Genetic Diseases, X-Linked - pathology Homeostasis Human health and pathology Hypoxia Impairment Integrity Lasers Life Sciences Long-term effects Medicine and Health Sciences Methods Mice Mice, Inbred C57BL Mice, Knockout Morphology Morphometry Mutation Neovascularization, Pathologic - etiology Neovascularization, Pathologic - pathology Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Nervous System Diseases - diagnostic imaging Nervous System Diseases - genetics Nervous System Diseases - pathology Neurodegeneration Norrie disease Nutrition research Ophthalmoscopy - methods Research and Analysis Methods Retina Retinal Degeneration Retinal Vessels - diagnostic imaging Retinal Vessels - pathology Risk factors Rodents Sensory Organs Signaling Spasms, Infantile - diagnostic imaging Spasms, Infantile - genetics Spasms, Infantile - pathology Stem cells Toxicology Vascular diseases Visual perception
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!