Plasma brain-derived neurotrophic factor concentration is a predictor of chronic kidney disease in patients with cardiovascular risk factors - Hyogo Sleep Cardio-Autonomic Atherosclerosis study
Brain-derived neurotrophic factor (BDNF) has been shown to have protective effects against cardiovascular diseases and death through neural and non-neural pathways via tropomyosin-related kinase B signaling. However, it is not known whether plasma BDNF concentration is a predictor of chronic kidney...
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| Veröffentlicht in: | PloS one 2017-06, Vol.12 (6), p.e0178686-e0178686 |
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| creator | Kurajoh, Masafumi Kadoya, Manabu Morimoto, Akiko Miyoshi, Akio Kanzaki, Akinori Kakutani-Hatayama, Miki Hamamoto, Kae Shoji, Takuhito Moriwaki, Yuji Yamamoto, Tetsuya Inaba, Masaaki Namba, Mitsuyoshi Koyama, Hidenori |
| description | Brain-derived neurotrophic factor (BDNF) has been shown to have protective effects against cardiovascular diseases and death through neural and non-neural pathways via tropomyosin-related kinase B signaling. However, it is not known whether plasma BDNF concentration is a predictor of chronic kidney disease (CKD).
This study was conducted as a prospective cohort study as part of the Hyogo Sleep Cardio-Autonomic Atherosclerosis.
We measured plasma BDNF concentration in 324 patients without CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2, and with cardiovascular risk factors. As potential confounders, sleep condition, nocturnal hypertension, and autonomic function were quantitatively examined. The patients were followed for a median 37 months (range 2-59 months) and occurrence of CKD was noted.
Plasma BDNF concentration was significantly and independently associated with CKD development, which occurred in 38 patients (11.7%). Kaplan-Meier analysis revealed that patients with reduced plasma BDNF concentration exhibited a significantly (p = 0.029) greater number of CKD events as compared to those with a higher concentration. Moreover, comparisons of key subgroups showed that the risk of CKD in association with low plasma BDNF concentration was more prominent in patients with a greater reduction of nocturnal systolic blood pressure, better movement index, higher standard deviations of the NN(RR) interval or average NN(RR) interval for each 5-minute period, and without past cardiovascular disease events, smoking habit, or albuminuria.
Plasma BDNF concentration is an independent predictor for development of CKD in patients with cardiovascular risk factors. |
| doi_str_mv | 10.1371/journal.pone.0178686 |
| format | Article |
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This study was conducted as a prospective cohort study as part of the Hyogo Sleep Cardio-Autonomic Atherosclerosis.
We measured plasma BDNF concentration in 324 patients without CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2, and with cardiovascular risk factors. As potential confounders, sleep condition, nocturnal hypertension, and autonomic function were quantitatively examined. The patients were followed for a median 37 months (range 2-59 months) and occurrence of CKD was noted.
Plasma BDNF concentration was significantly and independently associated with CKD development, which occurred in 38 patients (11.7%). Kaplan-Meier analysis revealed that patients with reduced plasma BDNF concentration exhibited a significantly (p = 0.029) greater number of CKD events as compared to those with a higher concentration. Moreover, comparisons of key subgroups showed that the risk of CKD in association with low plasma BDNF concentration was more prominent in patients with a greater reduction of nocturnal systolic blood pressure, better movement index, higher standard deviations of the NN(RR) interval or average NN(RR) interval for each 5-minute period, and without past cardiovascular disease events, smoking habit, or albuminuria.
Plasma BDNF concentration is an independent predictor for development of CKD in patients with cardiovascular risk factors.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0178686</identifier><identifier>PMID: 28575038</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Arteriosclerosis ; Atherosclerosis ; Atherosclerosis - epidemiology ; Autonomic nervous system ; Biology and Life Sciences ; Biomarkers - blood ; Blood ; Blood pressure ; Brain ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - blood ; Cardiovascular diseases ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Chronic kidney failure ; Comorbidity ; Death ; Design analysis ; Diabetes ; Diabetes Mellitus - epidemiology ; Diagnosis ; Dyslipidemias - epidemiology ; Epidermal growth factor receptors ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Health aspects ; Health risks ; Humans ; Hypertension ; Japan - epidemiology ; Kidney diseases ; Kidney transplantation ; Kidneys ; Male ; Measurement ; Measurement methods ; Medicine and Health Sciences ; Metabolic disorders ; Middle Aged ; Mortality ; Obesity - epidemiology ; Patients ; Proportional Hazards Models ; Prospective Studies ; Renal Insufficiency, Chronic - blood ; Risk analysis ; Risk Factors ; Rodents ; Signal transduction ; Sleep ; Sleep Wake Disorders - epidemiology ; Smoking ; Smoking - epidemiology ; Subgroups ; Tropomyosin</subject><ispartof>PloS one, 2017-06, Vol.12 (6), p.e0178686-e0178686</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Kurajoh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Kurajoh et al 2017 Kurajoh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-c084bc31961ed44588a106de2c245d387ec2d9895bb940982c8658653c74d0e3</citedby><cites>FETCH-LOGICAL-c692t-c084bc31961ed44588a106de2c245d387ec2d9895bb940982c8658653c74d0e3</cites><orcidid>0000-0002-2973-8143</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456118/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456118/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2100,2926,23864,27922,27923,53789,53791,79370,79371</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28575038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Shimosawa, Tatsuo</contributor><creatorcontrib>Kurajoh, Masafumi</creatorcontrib><creatorcontrib>Kadoya, Manabu</creatorcontrib><creatorcontrib>Morimoto, Akiko</creatorcontrib><creatorcontrib>Miyoshi, Akio</creatorcontrib><creatorcontrib>Kanzaki, Akinori</creatorcontrib><creatorcontrib>Kakutani-Hatayama, Miki</creatorcontrib><creatorcontrib>Hamamoto, Kae</creatorcontrib><creatorcontrib>Shoji, Takuhito</creatorcontrib><creatorcontrib>Moriwaki, Yuji</creatorcontrib><creatorcontrib>Yamamoto, Tetsuya</creatorcontrib><creatorcontrib>Inaba, Masaaki</creatorcontrib><creatorcontrib>Namba, Mitsuyoshi</creatorcontrib><creatorcontrib>Koyama, Hidenori</creatorcontrib><title>Plasma brain-derived neurotrophic factor concentration is a predictor of chronic kidney disease in patients with cardiovascular risk factors - Hyogo Sleep Cardio-Autonomic Atherosclerosis study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Brain-derived neurotrophic factor (BDNF) has been shown to have protective effects against cardiovascular diseases and death through neural and non-neural pathways via tropomyosin-related kinase B signaling. However, it is not known whether plasma BDNF concentration is a predictor of chronic kidney disease (CKD).
This study was conducted as a prospective cohort study as part of the Hyogo Sleep Cardio-Autonomic Atherosclerosis.
We measured plasma BDNF concentration in 324 patients without CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2, and with cardiovascular risk factors. As potential confounders, sleep condition, nocturnal hypertension, and autonomic function were quantitatively examined. The patients were followed for a median 37 months (range 2-59 months) and occurrence of CKD was noted.
Plasma BDNF concentration was significantly and independently associated with CKD development, which occurred in 38 patients (11.7%). Kaplan-Meier analysis revealed that patients with reduced plasma BDNF concentration exhibited a significantly (p = 0.029) greater number of CKD events as compared to those with a higher concentration. Moreover, comparisons of key subgroups showed that the risk of CKD in association with low plasma BDNF concentration was more prominent in patients with a greater reduction of nocturnal systolic blood pressure, better movement index, higher standard deviations of the NN(RR) interval or average NN(RR) interval for each 5-minute period, and without past cardiovascular disease events, smoking habit, or albuminuria.
Plasma BDNF concentration is an independent predictor for development of CKD in patients with cardiovascular risk factors.</description><subject>Adult</subject><subject>Aged</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>Atherosclerosis - epidemiology</subject><subject>Autonomic nervous system</subject><subject>Biology and Life Sciences</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Blood pressure</subject><subject>Brain</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Chronic kidney failure</subject><subject>Comorbidity</subject><subject>Death</subject><subject>Design analysis</subject><subject>Diabetes</subject><subject>Diabetes Mellitus - epidemiology</subject><subject>Diagnosis</subject><subject>Dyslipidemias - epidemiology</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Health aspects</subject><subject>Health risks</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Japan - epidemiology</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Kidneys</subject><subject>Male</subject><subject>Measurement</subject><subject>Measurement methods</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic disorders</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Obesity - epidemiology</subject><subject>Patients</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>Sleep</subject><subject>Sleep Wake Disorders - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurajoh, Masafumi</au><au>Kadoya, Manabu</au><au>Morimoto, Akiko</au><au>Miyoshi, Akio</au><au>Kanzaki, Akinori</au><au>Kakutani-Hatayama, Miki</au><au>Hamamoto, Kae</au><au>Shoji, Takuhito</au><au>Moriwaki, Yuji</au><au>Yamamoto, Tetsuya</au><au>Inaba, Masaaki</au><au>Namba, Mitsuyoshi</au><au>Koyama, Hidenori</au><au>Shimosawa, Tatsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma brain-derived neurotrophic factor concentration is a predictor of chronic kidney disease in patients with cardiovascular risk factors - Hyogo Sleep Cardio-Autonomic Atherosclerosis study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-06-02</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>e0178686</spage><epage>e0178686</epage><pages>e0178686-e0178686</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Brain-derived neurotrophic factor (BDNF) has been shown to have protective effects against cardiovascular diseases and death through neural and non-neural pathways via tropomyosin-related kinase B signaling. However, it is not known whether plasma BDNF concentration is a predictor of chronic kidney disease (CKD).
This study was conducted as a prospective cohort study as part of the Hyogo Sleep Cardio-Autonomic Atherosclerosis.
We measured plasma BDNF concentration in 324 patients without CKD, defined as an estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2, and with cardiovascular risk factors. As potential confounders, sleep condition, nocturnal hypertension, and autonomic function were quantitatively examined. The patients were followed for a median 37 months (range 2-59 months) and occurrence of CKD was noted.
Plasma BDNF concentration was significantly and independently associated with CKD development, which occurred in 38 patients (11.7%). Kaplan-Meier analysis revealed that patients with reduced plasma BDNF concentration exhibited a significantly (p = 0.029) greater number of CKD events as compared to those with a higher concentration. Moreover, comparisons of key subgroups showed that the risk of CKD in association with low plasma BDNF concentration was more prominent in patients with a greater reduction of nocturnal systolic blood pressure, better movement index, higher standard deviations of the NN(RR) interval or average NN(RR) interval for each 5-minute period, and without past cardiovascular disease events, smoking habit, or albuminuria.
Plasma BDNF concentration is an independent predictor for development of CKD in patients with cardiovascular risk factors.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28575038</pmid><doi>10.1371/journal.pone.0178686</doi><tpages>e0178686</tpages><orcidid>https://orcid.org/0000-0002-2973-8143</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-06, Vol.12 (6), p.e0178686-e0178686 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1905486201 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Arteriosclerosis Atherosclerosis Atherosclerosis - epidemiology Autonomic nervous system Biology and Life Sciences Biomarkers - blood Blood Blood pressure Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - blood Cardiovascular diseases Cardiovascular Diseases - blood Cardiovascular Diseases - epidemiology Chronic kidney failure Comorbidity Death Design analysis Diabetes Diabetes Mellitus - epidemiology Diagnosis Dyslipidemias - epidemiology Epidermal growth factor receptors Female Follow-Up Studies Glomerular Filtration Rate Health aspects Health risks Humans Hypertension Japan - epidemiology Kidney diseases Kidney transplantation Kidneys Male Measurement Measurement methods Medicine and Health Sciences Metabolic disorders Middle Aged Mortality Obesity - epidemiology Patients Proportional Hazards Models Prospective Studies Renal Insufficiency, Chronic - blood Risk analysis Risk Factors Rodents Signal transduction Sleep Sleep Wake Disorders - epidemiology Smoking Smoking - epidemiology Subgroups Tropomyosin |
| title | Plasma brain-derived neurotrophic factor concentration is a predictor of chronic kidney disease in patients with cardiovascular risk factors - Hyogo Sleep Cardio-Autonomic Atherosclerosis study |
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