Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage
The prevalence of intracranial aneurysms (IAs) has been proposed to be elevated in the patients with neurofibromatosis type 1 (NF1). Our aims were to determine the prevalence of NF1 in a large Finnish population based cohort of IA patients and, on the other hand, the occurrences of subarachnoid haem...
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| Veröffentlicht in: | PloS one 2017-06, Vol.12 (6), p.e0178711-e0178711 |
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| creator | Kurtelius, Arttu Kallionpää, Roope A Huttunen, Jukka Huttunen, Terhi J Helin, Katariina Koivisto, Timo Frösen, Juhana von Und Zu Fraunberg, Mikael Peltonen, Sirkku Peltonen, Juha Jääskeläinen, Juha E Lindgren, Antti E |
| description | The prevalence of intracranial aneurysms (IAs) has been proposed to be elevated in the patients with neurofibromatosis type 1 (NF1). Our aims were to determine the prevalence of NF1 in a large Finnish population based cohort of IA patients and, on the other hand, the occurrences of subarachnoid haemorrhage and unruptured intracranial aneurysms in a nationwide population-based cohort of NF1 patients and its matched ten-fold control cohort.
The Kuopio IA Database (www.kuopioneurosurgery.fi) includes all ruptured and unruptured IA cases admitted to the Kuopio University Hospital (KUH) from its defined Eastern Finnish catchment population since 1980. In this registry-based study, we cross-linked the Kuopio IA database with the Finnish national registry covering all hospital diagnoses. The NF1 diagnoses of the 4543 patients with either saccular of fusiform IA were identified from 1969 to 2015 and verified from patient records. Our second approach was to analyze the occurrence of aneurysmal subarachnoid haemorrhage (aSAH) and unruptured IAs in a nationwide population-based database of 1410 NF1 patients and its ten-fold matched control cohort (n = 14030) using national registry of hospital diagnoses between 1987 and 2014.
One NF1 patient was identified among the 4543 IA patients. Three verified IA cases (one unruptured IA and two aSAH cases) were identified in the cohort of 1410 NF1 patients, with similar occurrences in the control cohort.
We found no evidence in our population-based cohorts to support the conception that NF1 is associated with IAs. Our results indicate that the incidence of aSAH is not elevated in patients with NF1. Further studies are required to confirm that there is no association between NF1 and unruptured IAs. |
| doi_str_mv | 10.1371/journal.pone.0178711 |
| format | Article |
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The Kuopio IA Database (www.kuopioneurosurgery.fi) includes all ruptured and unruptured IA cases admitted to the Kuopio University Hospital (KUH) from its defined Eastern Finnish catchment population since 1980. In this registry-based study, we cross-linked the Kuopio IA database with the Finnish national registry covering all hospital diagnoses. The NF1 diagnoses of the 4543 patients with either saccular of fusiform IA were identified from 1969 to 2015 and verified from patient records. Our second approach was to analyze the occurrence of aneurysmal subarachnoid haemorrhage (aSAH) and unruptured IAs in a nationwide population-based database of 1410 NF1 patients and its ten-fold matched control cohort (n = 14030) using national registry of hospital diagnoses between 1987 and 2014.
One NF1 patient was identified among the 4543 IA patients. Three verified IA cases (one unruptured IA and two aSAH cases) were identified in the cohort of 1410 NF1 patients, with similar occurrences in the control cohort.
We found no evidence in our population-based cohorts to support the conception that NF1 is associated with IAs. Our results indicate that the incidence of aSAH is not elevated in patients with NF1. Further studies are required to confirm that there is no association between NF1 and unruptured IAs.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0178711</identifier><identifier>PMID: 28575128</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Aneurysm ; Aneurysm, Ruptured - epidemiology ; Aneurysm, Ruptured - etiology ; Aneurysms ; Case-Control Studies ; Catchment Area (Health) ; Children & youth ; Chromosomes ; Clinical medicine ; Control methods ; Crosslinking ; Data bases ; Databases, Factual ; Diagnosis ; Epidemiology ; Family Health ; Family medical history ; Female ; Finland - epidemiology ; Genetic disorders ; Hemorrhage ; Hospitals ; Hospitals, University - statistics & numerical data ; Humans ; Incidence ; International Classification of Diseases ; Intracranial Aneurysm - complications ; Intracranial Aneurysm - epidemiology ; Male ; Medical diagnosis ; Medical records ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mutation ; Nervous system ; Neurofibromatosis ; Neurofibromatosis 1 - complications ; Neurological disorders ; Neurosurgery ; Patients ; People and Places ; Population ; Prevalence ; Recklinghausen's disease ; Registries ; Research and Analysis Methods ; Saccule ; Stroke ; Subarachnoid hemorrhage ; Subarachnoid Hemorrhage - epidemiology ; Subarachnoid Hemorrhage - etiology ; Tumors ; Veins & arteries</subject><ispartof>PloS one, 2017-06, Vol.12 (6), p.e0178711-e0178711</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Kurtelius et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Kurtelius et al 2017 Kurtelius et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a497d05136d56b226c6a7cae315ae22014162ef833071aa6927834ad788365f93</citedby><cites>FETCH-LOGICAL-c692t-a497d05136d56b226c6a7cae315ae22014162ef833071aa6927834ad788365f93</cites><orcidid>0000-0002-1264-7667</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456355/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456355/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28575128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Meckel, Stephan</contributor><creatorcontrib>Kurtelius, Arttu</creatorcontrib><creatorcontrib>Kallionpää, Roope A</creatorcontrib><creatorcontrib>Huttunen, Jukka</creatorcontrib><creatorcontrib>Huttunen, Terhi J</creatorcontrib><creatorcontrib>Helin, Katariina</creatorcontrib><creatorcontrib>Koivisto, Timo</creatorcontrib><creatorcontrib>Frösen, Juhana</creatorcontrib><creatorcontrib>von Und Zu Fraunberg, Mikael</creatorcontrib><creatorcontrib>Peltonen, Sirkku</creatorcontrib><creatorcontrib>Peltonen, Juha</creatorcontrib><creatorcontrib>Jääskeläinen, Juha E</creatorcontrib><creatorcontrib>Lindgren, Antti E</creatorcontrib><title>Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The prevalence of intracranial aneurysms (IAs) has been proposed to be elevated in the patients with neurofibromatosis type 1 (NF1). Our aims were to determine the prevalence of NF1 in a large Finnish population based cohort of IA patients and, on the other hand, the occurrences of subarachnoid haemorrhage and unruptured intracranial aneurysms in a nationwide population-based cohort of NF1 patients and its matched ten-fold control cohort.
The Kuopio IA Database (www.kuopioneurosurgery.fi) includes all ruptured and unruptured IA cases admitted to the Kuopio University Hospital (KUH) from its defined Eastern Finnish catchment population since 1980. In this registry-based study, we cross-linked the Kuopio IA database with the Finnish national registry covering all hospital diagnoses. The NF1 diagnoses of the 4543 patients with either saccular of fusiform IA were identified from 1969 to 2015 and verified from patient records. Our second approach was to analyze the occurrence of aneurysmal subarachnoid haemorrhage (aSAH) and unruptured IAs in a nationwide population-based database of 1410 NF1 patients and its ten-fold matched control cohort (n = 14030) using national registry of hospital diagnoses between 1987 and 2014.
One NF1 patient was identified among the 4543 IA patients. Three verified IA cases (one unruptured IA and two aSAH cases) were identified in the cohort of 1410 NF1 patients, with similar occurrences in the control cohort.
We found no evidence in our population-based cohorts to support the conception that NF1 is associated with IAs. Our results indicate that the incidence of aSAH is not elevated in patients with NF1. Further studies are required to confirm that there is no association between NF1 and unruptured IAs.</description><subject>Adult</subject><subject>Analysis</subject><subject>Aneurysm</subject><subject>Aneurysm, Ruptured - epidemiology</subject><subject>Aneurysm, Ruptured - etiology</subject><subject>Aneurysms</subject><subject>Case-Control Studies</subject><subject>Catchment Area (Health)</subject><subject>Children & youth</subject><subject>Chromosomes</subject><subject>Clinical medicine</subject><subject>Control methods</subject><subject>Crosslinking</subject><subject>Data bases</subject><subject>Databases, Factual</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Family Health</subject><subject>Family medical history</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Genetic disorders</subject><subject>Hemorrhage</subject><subject>Hospitals</subject><subject>Hospitals, University - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>International Classification of Diseases</subject><subject>Intracranial Aneurysm - complications</subject><subject>Intracranial Aneurysm - epidemiology</subject><subject>Male</subject><subject>Medical diagnosis</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Nervous system</subject><subject>Neurofibromatosis</subject><subject>Neurofibromatosis 1 - complications</subject><subject>Neurological disorders</subject><subject>Neurosurgery</subject><subject>Patients</subject><subject>People and Places</subject><subject>Population</subject><subject>Prevalence</subject><subject>Recklinghausen's disease</subject><subject>Registries</subject><subject>Research and Analysis Methods</subject><subject>Saccule</subject><subject>Stroke</subject><subject>Subarachnoid hemorrhage</subject><subject>Subarachnoid Hemorrhage - epidemiology</subject><subject>Subarachnoid Hemorrhage - etiology</subject><subject>Tumors</subject><subject>Veins & arteries</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNkl2L1DAUhoso7of-A9GCsOjFjPlo0vZGWBZ1BxYX_LoNp-npNEPbzCapuv_ejNNdprIX0ouE5Hnfk3P6JskLSpaU5_Tdxo5ugG65tQMuCc2LnNJHyTEtOVtIRvjjg_1RcuL9hhDBCymfJkesELmgrDhOLj_j6GxjKmd7CNYbn4bbLaY0jbvBhhS8t9pAwDr9ZUKb-rECB7odrKnTFrC3zrWwxmfJkwY6j8-n9TT5_vHDt4vLxdX1p9XF-dVCy5KFBWRlXhNBuayFrBiTWkKuATkVgIwRmlHJsCk4JzkFiJq84BnUeVFwKZqSnyav9r7bzno1DcErWhKRFZKWNBKrPVFb2KitMz24W2XBqL8H1q0VuGB0h6qiJOe1LDPNeFZgA5QjJ7Emb7hoKha93k_VxqrHWuMQHHQz0_nNYFq1tj-VyITkQkSDN5OBszcj-qB64zV2HQxox_27c85icxF9_Q_6cHcTtYbYgBkaG-vqnak6z8qMUBaHG6nlA1T8auyNjolpTDyfCd7OBJEJ-DusYfRerb5--X_2-secPTtgW4QutN52YzB28HMw24PaWe8dNvdDpkTtAn83DbULvJoCH2UvD3_Qvegu4fwPQJL4yw</recordid><startdate>20170602</startdate><enddate>20170602</enddate><creator>Kurtelius, Arttu</creator><creator>Kallionpää, Roope A</creator><creator>Huttunen, Jukka</creator><creator>Huttunen, Terhi J</creator><creator>Helin, Katariina</creator><creator>Koivisto, Timo</creator><creator>Frösen, Juhana</creator><creator>von Und Zu Fraunberg, Mikael</creator><creator>Peltonen, Sirkku</creator><creator>Peltonen, Juha</creator><creator>Jääskeläinen, Juha E</creator><creator>Lindgren, Antti E</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1264-7667</orcidid></search><sort><creationdate>20170602</creationdate><title>Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage</title><author>Kurtelius, Arttu ; Kallionpää, Roope A ; Huttunen, Jukka ; Huttunen, Terhi J ; Helin, Katariina ; Koivisto, Timo ; Frösen, Juhana ; von Und Zu Fraunberg, Mikael ; Peltonen, Sirkku ; Peltonen, Juha ; Jääskeläinen, Juha E ; Lindgren, Antti E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-a497d05136d56b226c6a7cae315ae22014162ef833071aa6927834ad788365f93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Analysis</topic><topic>Aneurysm</topic><topic>Aneurysm, Ruptured - 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complications</topic><topic>Neurological disorders</topic><topic>Neurosurgery</topic><topic>Patients</topic><topic>People and Places</topic><topic>Population</topic><topic>Prevalence</topic><topic>Recklinghausen's disease</topic><topic>Registries</topic><topic>Research and Analysis Methods</topic><topic>Saccule</topic><topic>Stroke</topic><topic>Subarachnoid hemorrhage</topic><topic>Subarachnoid Hemorrhage - epidemiology</topic><topic>Subarachnoid Hemorrhage - etiology</topic><topic>Tumors</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kurtelius, Arttu</creatorcontrib><creatorcontrib>Kallionpää, Roope A</creatorcontrib><creatorcontrib>Huttunen, Jukka</creatorcontrib><creatorcontrib>Huttunen, Terhi J</creatorcontrib><creatorcontrib>Helin, Katariina</creatorcontrib><creatorcontrib>Koivisto, Timo</creatorcontrib><creatorcontrib>Frösen, Juhana</creatorcontrib><creatorcontrib>von Und Zu Fraunberg, Mikael</creatorcontrib><creatorcontrib>Peltonen, Sirkku</creatorcontrib><creatorcontrib>Peltonen, Juha</creatorcontrib><creatorcontrib>Jääskeläinen, Juha E</creatorcontrib><creatorcontrib>Lindgren, Antti E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kurtelius, Arttu</au><au>Kallionpää, Roope A</au><au>Huttunen, Jukka</au><au>Huttunen, Terhi J</au><au>Helin, Katariina</au><au>Koivisto, Timo</au><au>Frösen, Juhana</au><au>von Und Zu Fraunberg, Mikael</au><au>Peltonen, Sirkku</au><au>Peltonen, Juha</au><au>Jääskeläinen, Juha E</au><au>Lindgren, Antti E</au><au>Meckel, Stephan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-06-02</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>e0178711</spage><epage>e0178711</epage><pages>e0178711-e0178711</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The prevalence of intracranial aneurysms (IAs) has been proposed to be elevated in the patients with neurofibromatosis type 1 (NF1). Our aims were to determine the prevalence of NF1 in a large Finnish population based cohort of IA patients and, on the other hand, the occurrences of subarachnoid haemorrhage and unruptured intracranial aneurysms in a nationwide population-based cohort of NF1 patients and its matched ten-fold control cohort.
The Kuopio IA Database (www.kuopioneurosurgery.fi) includes all ruptured and unruptured IA cases admitted to the Kuopio University Hospital (KUH) from its defined Eastern Finnish catchment population since 1980. In this registry-based study, we cross-linked the Kuopio IA database with the Finnish national registry covering all hospital diagnoses. The NF1 diagnoses of the 4543 patients with either saccular of fusiform IA were identified from 1969 to 2015 and verified from patient records. Our second approach was to analyze the occurrence of aneurysmal subarachnoid haemorrhage (aSAH) and unruptured IAs in a nationwide population-based database of 1410 NF1 patients and its ten-fold matched control cohort (n = 14030) using national registry of hospital diagnoses between 1987 and 2014.
One NF1 patient was identified among the 4543 IA patients. Three verified IA cases (one unruptured IA and two aSAH cases) were identified in the cohort of 1410 NF1 patients, with similar occurrences in the control cohort.
We found no evidence in our population-based cohorts to support the conception that NF1 is associated with IAs. Our results indicate that the incidence of aSAH is not elevated in patients with NF1. Further studies are required to confirm that there is no association between NF1 and unruptured IAs.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28575128</pmid><doi>10.1371/journal.pone.0178711</doi><tpages>e0178711</tpages><orcidid>https://orcid.org/0000-0002-1264-7667</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-06, Vol.12 (6), p.e0178711-e0178711 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1905486191 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Analysis Aneurysm Aneurysm, Ruptured - epidemiology Aneurysm, Ruptured - etiology Aneurysms Case-Control Studies Catchment Area (Health) Children & youth Chromosomes Clinical medicine Control methods Crosslinking Data bases Databases, Factual Diagnosis Epidemiology Family Health Family medical history Female Finland - epidemiology Genetic disorders Hemorrhage Hospitals Hospitals, University - statistics & numerical data Humans Incidence International Classification of Diseases Intracranial Aneurysm - complications Intracranial Aneurysm - epidemiology Male Medical diagnosis Medical records Medicine Medicine and Health Sciences Middle Aged Mutation Nervous system Neurofibromatosis Neurofibromatosis 1 - complications Neurological disorders Neurosurgery Patients People and Places Population Prevalence Recklinghausen's disease Registries Research and Analysis Methods Saccule Stroke Subarachnoid hemorrhage Subarachnoid Hemorrhage - epidemiology Subarachnoid Hemorrhage - etiology Tumors Veins & arteries |
| title | Neurofibromatosis type 1 is not associated with subarachnoid haemorrhage |
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