Relationships of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort
Impacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood. This study evaluated combined relationships of systemic inflammation and body size with insulin resistance in a Ja...
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| Veröffentlicht in: | PloS one 2017-06, Vol.12 (6), p.e0178672-e0178672 |
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| creator | Uemura, Hirokazu Katsuura-Kamano, Sakurako Yamaguchi, Miwa Bahari, Tirani Ishizu, Masashi Fujioka, Miho Arisawa, Kokichi |
| description | Impacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood. This study evaluated combined relationships of systemic inflammation and body size with insulin resistance in a Japanese cohort.
We analyzed cross-sectional data from 1,074 eligible subjects (536 men and 538 women) aged 35-69 years who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Systemic inflammation level was assessed by serum high-sensitivity C-reactive protein (hs-CRP), and the degree of insulin resistance and beta-cell function were evaluated by the homeostasis model assessment insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), respectively. Overweight and obesity were defined as a body mass index (BMI) of 23.0-24.9 kg/m2 and ≥25.0 kg/m2, respectively. Associations between serum hs-CRP (assessed as quartiles and additionally continuous values after log-transformation) and indices of glucose homeostasis were analysed adjusting for probable covariates, including BMI (quartiles). Combined associations of serum hs-CRP (≤median, >median) and body size (normal, overweight, obese) with insulin resistance as well as their interaction effect on insulin resistance were also evaluated.
Serum hs-CRP was dose-dependently associated with HOMA-IR, but not HOMA-β, after adjustment for probable covariates, including BMI. Subjects with obesity and elevated serum hs-CRP (>median) showed a high multivariable-adjusted HOMA-IR value of 1.32 (95% confidence interval (CI) 1.23, 1.41) compared with subjects with normal BMI and low serum hs-CRP (≤median) whose multivariable-adjusted HOMA-IR value was 1.14 (95% CI 1.06, 1.21). The interaction effect between body size (normal, overweight, obese) and serum hs-CRP (≤median, >median) on HOMA-IR was significant (P for interaction |
| doi_str_mv | 10.1371/journal.pone.0178672 |
| format | Article |
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We analyzed cross-sectional data from 1,074 eligible subjects (536 men and 538 women) aged 35-69 years who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Systemic inflammation level was assessed by serum high-sensitivity C-reactive protein (hs-CRP), and the degree of insulin resistance and beta-cell function were evaluated by the homeostasis model assessment insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), respectively. Overweight and obesity were defined as a body mass index (BMI) of 23.0-24.9 kg/m2 and ≥25.0 kg/m2, respectively. Associations between serum hs-CRP (assessed as quartiles and additionally continuous values after log-transformation) and indices of glucose homeostasis were analysed adjusting for probable covariates, including BMI (quartiles). Combined associations of serum hs-CRP (≤median, >median) and body size (normal, overweight, obese) with insulin resistance as well as their interaction effect on insulin resistance were also evaluated.
Serum hs-CRP was dose-dependently associated with HOMA-IR, but not HOMA-β, after adjustment for probable covariates, including BMI. Subjects with obesity and elevated serum hs-CRP (>median) showed a high multivariable-adjusted HOMA-IR value of 1.32 (95% confidence interval (CI) 1.23, 1.41) compared with subjects with normal BMI and low serum hs-CRP (≤median) whose multivariable-adjusted HOMA-IR value was 1.14 (95% CI 1.06, 1.21). The interaction effect between body size (normal, overweight, obese) and serum hs-CRP (≤median, >median) on HOMA-IR was significant (P for interaction <0.001).
Our study suggests that elevated systemic inflammation is dose-dependently associated with increased insulin resistance, independent of the known risk factors, in a Japanese population. Concomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0178672</identifier><identifier>PMID: 28575103</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adjustment ; Adult ; Aged ; Anthropometry ; Asian people ; Beta cells ; Biology and Life Sciences ; Body composition ; Body mass ; Body mass index ; Body Size ; Body weight ; C-reactive protein ; C-Reactive Protein - analysis ; Cardiovascular disease ; Confidence intervals ; Cross-Sectional Studies ; Cytokines ; Data processing ; Diabetes ; Diet ; Disease prevention ; Exercise ; Family medical history ; Female ; Food ; Genetic aspects ; Glucose - metabolism ; Health aspects ; Health risk assessment ; Health Surveys ; Homeostasis ; Humans ; Hyperglycemia - epidemiology ; Inflammation ; Inflammation - epidemiology ; Insulin ; Insulin Resistance ; Japan - epidemiology ; Life Style ; Lifestyles ; Male ; Medicine and Health Sciences ; Men ; Mens health ; Metabolism ; Middle Aged ; Obesity ; Overweight ; Overweight - epidemiology ; Preventive medicine ; Prospective Studies ; Proteins ; Quartiles ; Questionnaires ; Risk analysis ; Risk factors ; Sensitivity ; Sensitivity analysis ; Studies ; Transformation ; University graduates ; Values ; Womens health</subject><ispartof>PloS one, 2017-06, Vol.12 (6), p.e0178672-e0178672</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Uemura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Uemura et al 2017 Uemura et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6732-a38e57da777f15dd75f25ca84c055d907fc6bc26e4484123071c74babf996da3</citedby><cites>FETCH-LOGICAL-c6732-a38e57da777f15dd75f25ca84c055d907fc6bc26e4484123071c74babf996da3</cites><orcidid>0000-0002-0443-4266</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456096/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5456096/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28575103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Herder, Christian</contributor><creatorcontrib>Uemura, Hirokazu</creatorcontrib><creatorcontrib>Katsuura-Kamano, Sakurako</creatorcontrib><creatorcontrib>Yamaguchi, Miwa</creatorcontrib><creatorcontrib>Bahari, Tirani</creatorcontrib><creatorcontrib>Ishizu, Masashi</creatorcontrib><creatorcontrib>Fujioka, Miho</creatorcontrib><creatorcontrib>Arisawa, Kokichi</creatorcontrib><title>Relationships of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Impacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood. This study evaluated combined relationships of systemic inflammation and body size with insulin resistance in a Japanese cohort.
We analyzed cross-sectional data from 1,074 eligible subjects (536 men and 538 women) aged 35-69 years who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Systemic inflammation level was assessed by serum high-sensitivity C-reactive protein (hs-CRP), and the degree of insulin resistance and beta-cell function were evaluated by the homeostasis model assessment insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), respectively. Overweight and obesity were defined as a body mass index (BMI) of 23.0-24.9 kg/m2 and ≥25.0 kg/m2, respectively. Associations between serum hs-CRP (assessed as quartiles and additionally continuous values after log-transformation) and indices of glucose homeostasis were analysed adjusting for probable covariates, including BMI (quartiles). Combined associations of serum hs-CRP (≤median, >median) and body size (normal, overweight, obese) with insulin resistance as well as their interaction effect on insulin resistance were also evaluated.
Serum hs-CRP was dose-dependently associated with HOMA-IR, but not HOMA-β, after adjustment for probable covariates, including BMI. Subjects with obesity and elevated serum hs-CRP (>median) showed a high multivariable-adjusted HOMA-IR value of 1.32 (95% confidence interval (CI) 1.23, 1.41) compared with subjects with normal BMI and low serum hs-CRP (≤median) whose multivariable-adjusted HOMA-IR value was 1.14 (95% CI 1.06, 1.21). The interaction effect between body size (normal, overweight, obese) and serum hs-CRP (≤median, >median) on HOMA-IR was significant (P for interaction <0.001).
Our study suggests that elevated systemic inflammation is dose-dependently associated with increased insulin resistance, independent of the known risk factors, in a Japanese population. Concomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance.</description><subject>Adjustment</subject><subject>Adult</subject><subject>Aged</subject><subject>Anthropometry</subject><subject>Asian people</subject><subject>Beta cells</subject><subject>Biology and Life Sciences</subject><subject>Body composition</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body Size</subject><subject>Body weight</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>Cardiovascular disease</subject><subject>Confidence intervals</subject><subject>Cross-Sectional Studies</subject><subject>Cytokines</subject><subject>Data processing</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Disease prevention</subject><subject>Exercise</subject><subject>Family medical history</subject><subject>Female</subject><subject>Food</subject><subject>Genetic aspects</subject><subject>Glucose - metabolism</subject><subject>Health aspects</subject><subject>Health risk assessment</subject><subject>Health Surveys</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Hyperglycemia - epidemiology</subject><subject>Inflammation</subject><subject>Inflammation - epidemiology</subject><subject>Insulin</subject><subject>Insulin Resistance</subject><subject>Japan - epidemiology</subject><subject>Life Style</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Men</subject><subject>Mens health</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Overweight</subject><subject>Overweight - epidemiology</subject><subject>Preventive medicine</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Quartiles</subject><subject>Questionnaires</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Sensitivity</subject><subject>Sensitivity analysis</subject><subject>Studies</subject><subject>Transformation</subject><subject>University graduates</subject><subject>Values</subject><subject>Womens 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of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort</title><author>Uemura, Hirokazu ; Katsuura-Kamano, Sakurako ; Yamaguchi, Miwa ; Bahari, Tirani ; Ishizu, Masashi ; Fujioka, Miho ; Arisawa, Kokichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6732-a38e57da777f15dd75f25ca84c055d907fc6bc26e4484123071c74babf996da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adjustment</topic><topic>Adult</topic><topic>Aged</topic><topic>Anthropometry</topic><topic>Asian people</topic><topic>Beta cells</topic><topic>Biology and Life Sciences</topic><topic>Body composition</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body Size</topic><topic>Body weight</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>Cardiovascular disease</topic><topic>Confidence 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one</jtitle><addtitle>PLoS One</addtitle><date>2017-06-02</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>e0178672</spage><epage>e0178672</epage><pages>e0178672-e0178672</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Impacts of chronic systemic inflammation and body size and their interaction effect on insulin resistance in Asian populations, in whom obesity is less common, are not fully understood. This study evaluated combined relationships of systemic inflammation and body size with insulin resistance in a Japanese cohort.
We analyzed cross-sectional data from 1,074 eligible subjects (536 men and 538 women) aged 35-69 years who participated in the baseline survey of a cohort study in Tokushima Prefecture, Japan. Systemic inflammation level was assessed by serum high-sensitivity C-reactive protein (hs-CRP), and the degree of insulin resistance and beta-cell function were evaluated by the homeostasis model assessment insulin resistance (HOMA-IR) and beta-cell function (HOMA-β), respectively. Overweight and obesity were defined as a body mass index (BMI) of 23.0-24.9 kg/m2 and ≥25.0 kg/m2, respectively. Associations between serum hs-CRP (assessed as quartiles and additionally continuous values after log-transformation) and indices of glucose homeostasis were analysed adjusting for probable covariates, including BMI (quartiles). Combined associations of serum hs-CRP (≤median, >median) and body size (normal, overweight, obese) with insulin resistance as well as their interaction effect on insulin resistance were also evaluated.
Serum hs-CRP was dose-dependently associated with HOMA-IR, but not HOMA-β, after adjustment for probable covariates, including BMI. Subjects with obesity and elevated serum hs-CRP (>median) showed a high multivariable-adjusted HOMA-IR value of 1.32 (95% confidence interval (CI) 1.23, 1.41) compared with subjects with normal BMI and low serum hs-CRP (≤median) whose multivariable-adjusted HOMA-IR value was 1.14 (95% CI 1.06, 1.21). The interaction effect between body size (normal, overweight, obese) and serum hs-CRP (≤median, >median) on HOMA-IR was significant (P for interaction <0.001).
Our study suggests that elevated systemic inflammation is dose-dependently associated with increased insulin resistance, independent of the known risk factors, in a Japanese population. Concomitant obesity and elevated systemic inflammation may synergistically contribute to increased insulin resistance.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28575103</pmid><doi>10.1371/journal.pone.0178672</doi><tpages>e0178672</tpages><orcidid>https://orcid.org/0000-0002-0443-4266</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-06, Vol.12 (6), p.e0178672-e0178672 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1905486015 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adjustment Adult Aged Anthropometry Asian people Beta cells Biology and Life Sciences Body composition Body mass Body mass index Body Size Body weight C-reactive protein C-Reactive Protein - analysis Cardiovascular disease Confidence intervals Cross-Sectional Studies Cytokines Data processing Diabetes Diet Disease prevention Exercise Family medical history Female Food Genetic aspects Glucose - metabolism Health aspects Health risk assessment Health Surveys Homeostasis Humans Hyperglycemia - epidemiology Inflammation Inflammation - epidemiology Insulin Insulin Resistance Japan - epidemiology Life Style Lifestyles Male Medicine and Health Sciences Men Mens health Metabolism Middle Aged Obesity Overweight Overweight - epidemiology Preventive medicine Prospective Studies Proteins Quartiles Questionnaires Risk analysis Risk factors Sensitivity Sensitivity analysis Studies Transformation University graduates Values Womens health |
| title | Relationships of serum high-sensitivity C-reactive protein and body size with insulin resistance in a Japanese cohort |
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