The role of reactive oxygen intermediates in the intracellular fate of Leptospira interrogans in the macrophages of different hosts

Pathogenic species of Leptospira cause leptospirosis, a global zoonotic disease. Our previous work showed that leptospires survive and replicate in human macrophages but are killed in murine macrophages. However, the mechanism responsible for the different intracellular fates of leptospires within t...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0178618-e0178618
Hauptverfasser:	Li, Shijun, Li, Peili, Zhang, Lei, Hu, Weilin, Wang, Ming, Liu, Ying, Tang, Guangpeng, Wang, Dingming, Zhou, Bijun, Yan, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal sciences Animals Apoptosis Biology and Life Sciences Cell Line Control Damage localization Damage prevention Defense mechanisms Disease control Disease prevention Fluorescence Gram-negative bacteria Host-Pathogen Interactions Humans Immunology Infections Inhibitors Intermediates Intracellular Leptospira interrogans - physiology Leptospirosis Listeria Localization Lysosomes Macrophages Macrophages - metabolism Macrophages - microbiology Medicine and Health Sciences Mice NAD(P)H oxidase Neutrophils Nitric oxide Oxidase Oxygen Parasitology Physical Sciences Physiological aspects Position (location) Reactive oxygen species Reactive Oxygen Species - metabolism Research and Analysis Methods Superoxide Urine Vacuoles Viability Zoology Zoonoses
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