Validation of a scale for assessing attitudes towards outcomes of genetic cancer testing among primary care providers and breast specialists
To develop a generic scale for assessing attitudes towards genetic testing and to psychometrically assess these attitudes in the context of BRCA1/2 among a sample of French general practitioners, breast specialists and gyneco-obstetricians. Nested within the questionnaire developed for the European...
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| Veröffentlicht in: | PloS one 2017-06, Vol.12 (6), p.e0178447-e0178447 |
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| creator | Bouhnik, Anne-Deborah N'Diaye, Khadim Evans, D Gareth Harris, Hilary Tibben, Aad van Asperen, Christi Schmidtke, Joerg Nippert, Irmgard Mancini, Julien Julian-Reynier, Claire |
| description | To develop a generic scale for assessing attitudes towards genetic testing and to psychometrically assess these attitudes in the context of BRCA1/2 among a sample of French general practitioners, breast specialists and gyneco-obstetricians.
Nested within the questionnaire developed for the European InCRisC (International Cancer Risk Communication Study) project were 14 items assessing expected benefits (8 items) and drawbacks (6 items) of the process of breast/ovarian genetic cancer testing (BRCA1/2). Another item assessed agreement with the statement that, overall, the expected health benefits of BRCA1/2 testing exceeded its drawbacks, thereby justifying its prescription. The questionnaire was mailed to a sample of 1,852 French doctors. Of these, 182 breast specialists, 275 general practitioners and 294 gyneco-obstetricians completed and returned the questionnaire to the research team. Principal Component Analysis, Cronbach's α coefficient, and Pearson's correlation coefficients were used in the statistical analyses of collected data.
Three dimensions emerged from the respondents' responses, and were classified under the headings: "Anxiety, Conflict and Discrimination", "Risk Information", and "Prevention and Surveillance". Cronbach's α coefficient for the 3 dimensions was 0.79, 0.76 and 0.62, respectively, and each dimension exhibited strong correlation with the overall indicator of agreement (criterion validity).
The validation process of the 15 items regarding BRCA1/2 testing revealed satisfactory psychometric properties for the creation of a new scale entitled the Attitudes Towards Genetic Testing for BRCA1/2 (ATGT-BRCA1/2) Scale. Further testing is required to confirm the validity of this tool which could be used generically in other genetic contexts. |
| doi_str_mv | 10.1371/journal.pone.0178447 |
| format | Article |
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Nested within the questionnaire developed for the European InCRisC (International Cancer Risk Communication Study) project were 14 items assessing expected benefits (8 items) and drawbacks (6 items) of the process of breast/ovarian genetic cancer testing (BRCA1/2). Another item assessed agreement with the statement that, overall, the expected health benefits of BRCA1/2 testing exceeded its drawbacks, thereby justifying its prescription. The questionnaire was mailed to a sample of 1,852 French doctors. Of these, 182 breast specialists, 275 general practitioners and 294 gyneco-obstetricians completed and returned the questionnaire to the research team. Principal Component Analysis, Cronbach's α coefficient, and Pearson's correlation coefficients were used in the statistical analyses of collected data.
Three dimensions emerged from the respondents' responses, and were classified under the headings: "Anxiety, Conflict and Discrimination", "Risk Information", and "Prevention and Surveillance". Cronbach's α coefficient for the 3 dimensions was 0.79, 0.76 and 0.62, respectively, and each dimension exhibited strong correlation with the overall indicator of agreement (criterion validity).
The validation process of the 15 items regarding BRCA1/2 testing revealed satisfactory psychometric properties for the creation of a new scale entitled the Attitudes Towards Genetic Testing for BRCA1/2 (ATGT-BRCA1/2) Scale. Further testing is required to confirm the validity of this tool which could be used generically in other genetic contexts.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0178447</identifier><identifier>PMID: 28570656</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Anxiety ; Attitude of Health Personnel ; Attitudes ; Biology and Life Sciences ; BRCA mutations ; BRCA1 protein ; Breast cancer ; Breast Neoplasms - genetics ; Cancer ; Correlation ; Correlation analysis ; Correlation coefficient ; Correlation coefficients ; Criteria ; Data processing ; Design analysis ; Diagnosis ; Discrimination ; Doctors ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic aspects ; Genetic Predisposition to Disease ; Genetic screening ; Genetic Testing ; Health care ; Health risks ; Humans ; Life Sciences ; Management ; Mastectomy ; Medical personnel ; Medicine ; Medicine and Health Sciences ; Mutation ; Ovarian cancer ; People and Places ; Physical Sciences ; Physicians ; Physicians, Primary Care - psychology ; Prevention ; Primary health care ; Principal Component Analysis ; Principal components analysis ; Research and Analysis Methods ; Risk assessment ; Risk communication ; Social Sciences ; Statistical analysis ; Statistical analysis of data ; Statistics ; Surveillance ; Surveys</subject><ispartof>PloS one, 2017-06, Vol.12 (6), p.e0178447-e0178447</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Bouhnik et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><rights>2017 Bouhnik et al 2017 Bouhnik et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c729t-9d1f56d409837ee33994bd043e15977e35880b53d36bf022954095961cd830653</citedby><cites>FETCH-LOGICAL-c729t-9d1f56d409837ee33994bd043e15977e35880b53d36bf022954095961cd830653</cites><orcidid>0000-0002-5418-4592 ; 0000-0001-9500-8598</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453525/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453525/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28570656$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://inserm.hal.science/inserm-02593059$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouhnik, Anne-Deborah</creatorcontrib><creatorcontrib>N'Diaye, Khadim</creatorcontrib><creatorcontrib>Evans, D Gareth</creatorcontrib><creatorcontrib>Harris, Hilary</creatorcontrib><creatorcontrib>Tibben, Aad</creatorcontrib><creatorcontrib>van Asperen, Christi</creatorcontrib><creatorcontrib>Schmidtke, Joerg</creatorcontrib><creatorcontrib>Nippert, Irmgard</creatorcontrib><creatorcontrib>Mancini, Julien</creatorcontrib><creatorcontrib>Julian-Reynier, Claire</creatorcontrib><title>Validation of a scale for assessing attitudes towards outcomes of genetic cancer testing among primary care providers and breast specialists</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To develop a generic scale for assessing attitudes towards genetic testing and to psychometrically assess these attitudes in the context of BRCA1/2 among a sample of French general practitioners, breast specialists and gyneco-obstetricians.
Nested within the questionnaire developed for the European InCRisC (International Cancer Risk Communication Study) project were 14 items assessing expected benefits (8 items) and drawbacks (6 items) of the process of breast/ovarian genetic cancer testing (BRCA1/2). Another item assessed agreement with the statement that, overall, the expected health benefits of BRCA1/2 testing exceeded its drawbacks, thereby justifying its prescription. The questionnaire was mailed to a sample of 1,852 French doctors. Of these, 182 breast specialists, 275 general practitioners and 294 gyneco-obstetricians completed and returned the questionnaire to the research team. Principal Component Analysis, Cronbach's α coefficient, and Pearson's correlation coefficients were used in the statistical analyses of collected data.
Three dimensions emerged from the respondents' responses, and were classified under the headings: "Anxiety, Conflict and Discrimination", "Risk Information", and "Prevention and Surveillance". Cronbach's α coefficient for the 3 dimensions was 0.79, 0.76 and 0.62, respectively, and each dimension exhibited strong correlation with the overall indicator of agreement (criterion validity).
The validation process of the 15 items regarding BRCA1/2 testing revealed satisfactory psychometric properties for the creation of a new scale entitled the Attitudes Towards Genetic Testing for BRCA1/2 (ATGT-BRCA1/2) Scale. Further testing is required to confirm the validity of this tool which could be used generically in other genetic contexts.</description><subject>Anxiety</subject><subject>Attitude of Health Personnel</subject><subject>Attitudes</subject><subject>Biology and Life Sciences</subject><subject>BRCA mutations</subject><subject>BRCA1 protein</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - genetics</subject><subject>Cancer</subject><subject>Correlation</subject><subject>Correlation analysis</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Criteria</subject><subject>Data processing</subject><subject>Design analysis</subject><subject>Diagnosis</subject><subject>Discrimination</subject><subject>Doctors</subject><subject>Female</subject><subject>Genes, BRCA1</subject><subject>Genes, BRCA2</subject><subject>Genetic aspects</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic screening</subject><subject>Genetic Testing</subject><subject>Health care</subject><subject>Health risks</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Management</subject><subject>Mastectomy</subject><subject>Medical personnel</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Mutation</subject><subject>Ovarian cancer</subject><subject>People and Places</subject><subject>Physical Sciences</subject><subject>Physicians</subject><subject>Physicians, Primary Care - psychology</subject><subject>Prevention</subject><subject>Primary health care</subject><subject>Principal Component Analysis</subject><subject>Principal components analysis</subject><subject>Research and Analysis Methods</subject><subject>Risk assessment</subject><subject>Risk communication</subject><subject>Social Sciences</subject><subject>Statistical analysis</subject><subject>Statistical analysis of data</subject><subject>Statistics</subject><subject>Surveillance</subject><subject>Surveys</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk91qFDEUxwdRbK2-gWhAEAV3zUwmk8mNUIraQqHgR29DNjnZTZmZbHMyVd_BhzbbnZZu6YUMzGSS3_985ZyieFnSeclE-fEijHHQ3XwdBpjTUrR1LR4V-6Vk1aypKHt8Z71XPEO8oJSztmmeFntVywVteLNf_D3Xnbc6-TCQ4IgmaHQHxIVINCIg-mFJdEo-jRaQpPBLR4skjMmEPm9kzRIGSN4QowcDkSTAdC3qQ36vo-91_JMPI-SfcOUtRCR6sGQRQWMiuAbjcxCY8HnxxOkO4cX0PSh-fvn84-h4dnr29eTo8HRmRCXTTNrS8cbWVLZMADAmZb2wtGZQcikEMN62dMGZZc3C0aqSPKNcNqWxLctps4Pi9dbuuguopkKiKiWtpeCCiUycbAkb9IWaklBBe3W9EeJS6ZiT7kBpx93CNcI6amrQTppaatvWNodpjTXZ1qfJ27jowRoYUtTdjtHdk8Gv1DJcKV5zxqtNuB-2Blb3ZMeHp8oPCLFXtOKSUS6vyoy_m_zFcDnm21C9RwNdpwcI43WaOceGtyyjb-6hDxdjopa5NbJDF3KYZmNUHdaStaLJvjM1f4DKj4Xem9ykzuf9HcH7HUFmEvxOSz0iqpPv3_6fPTvfZd_eYVegu7TC0I2bHsddsN6CJgbECO62uCVVmxm7qYbazJiaZizLXt29z1vRzVCxf995I7g</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Bouhnik, 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of a scale for assessing attitudes towards outcomes of genetic cancer testing among primary care providers and breast specialists</title><author>Bouhnik, Anne-Deborah ; N'Diaye, Khadim ; Evans, D Gareth ; Harris, Hilary ; Tibben, Aad ; van Asperen, Christi ; Schmidtke, Joerg ; Nippert, Irmgard ; Mancini, Julien ; Julian-Reynier, Claire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c729t-9d1f56d409837ee33994bd043e15977e35880b53d36bf022954095961cd830653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anxiety</topic><topic>Attitude of Health Personnel</topic><topic>Attitudes</topic><topic>Biology and Life Sciences</topic><topic>BRCA mutations</topic><topic>BRCA1 protein</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - genetics</topic><topic>Cancer</topic><topic>Correlation</topic><topic>Correlation analysis</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Criteria</topic><topic>Data processing</topic><topic>Design analysis</topic><topic>Diagnosis</topic><topic>Discrimination</topic><topic>Doctors</topic><topic>Female</topic><topic>Genes, BRCA1</topic><topic>Genes, BRCA2</topic><topic>Genetic aspects</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic screening</topic><topic>Genetic Testing</topic><topic>Health care</topic><topic>Health risks</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Management</topic><topic>Mastectomy</topic><topic>Medical personnel</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Mutation</topic><topic>Ovarian cancer</topic><topic>People and Places</topic><topic>Physical Sciences</topic><topic>Physicians</topic><topic>Physicians, Primary Care - psychology</topic><topic>Prevention</topic><topic>Primary health care</topic><topic>Principal Component Analysis</topic><topic>Principal 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Joerg</au><au>Nippert, Irmgard</au><au>Mancini, Julien</au><au>Julian-Reynier, Claire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Validation of a scale for assessing attitudes towards outcomes of genetic cancer testing among primary care providers and breast specialists</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>12</volume><issue>6</issue><spage>e0178447</spage><epage>e0178447</epage><pages>e0178447-e0178447</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To develop a generic scale for assessing attitudes towards genetic testing and to psychometrically assess these attitudes in the context of BRCA1/2 among a sample of French general practitioners, breast specialists and gyneco-obstetricians.
Nested within the questionnaire developed for the European InCRisC (International Cancer Risk Communication Study) project were 14 items assessing expected benefits (8 items) and drawbacks (6 items) of the process of breast/ovarian genetic cancer testing (BRCA1/2). Another item assessed agreement with the statement that, overall, the expected health benefits of BRCA1/2 testing exceeded its drawbacks, thereby justifying its prescription. The questionnaire was mailed to a sample of 1,852 French doctors. Of these, 182 breast specialists, 275 general practitioners and 294 gyneco-obstetricians completed and returned the questionnaire to the research team. Principal Component Analysis, Cronbach's α coefficient, and Pearson's correlation coefficients were used in the statistical analyses of collected data.
Three dimensions emerged from the respondents' responses, and were classified under the headings: "Anxiety, Conflict and Discrimination", "Risk Information", and "Prevention and Surveillance". Cronbach's α coefficient for the 3 dimensions was 0.79, 0.76 and 0.62, respectively, and each dimension exhibited strong correlation with the overall indicator of agreement (criterion validity).
The validation process of the 15 items regarding BRCA1/2 testing revealed satisfactory psychometric properties for the creation of a new scale entitled the Attitudes Towards Genetic Testing for BRCA1/2 (ATGT-BRCA1/2) Scale. Further testing is required to confirm the validity of this tool which could be used generically in other genetic contexts.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28570656</pmid><doi>10.1371/journal.pone.0178447</doi><tpages>e0178447</tpages><orcidid>https://orcid.org/0000-0002-5418-4592</orcidid><orcidid>https://orcid.org/0000-0001-9500-8598</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-06, Vol.12 (6), p.e0178447-e0178447 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1904975737 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Anxiety Attitude of Health Personnel Attitudes Biology and Life Sciences BRCA mutations BRCA1 protein Breast cancer Breast Neoplasms - genetics Cancer Correlation Correlation analysis Correlation coefficient Correlation coefficients Criteria Data processing Design analysis Diagnosis Discrimination Doctors Female Genes, BRCA1 Genes, BRCA2 Genetic aspects Genetic Predisposition to Disease Genetic screening Genetic Testing Health care Health risks Humans Life Sciences Management Mastectomy Medical personnel Medicine Medicine and Health Sciences Mutation Ovarian cancer People and Places Physical Sciences Physicians Physicians, Primary Care - psychology Prevention Primary health care Principal Component Analysis Principal components analysis Research and Analysis Methods Risk assessment Risk communication Social Sciences Statistical analysis Statistical analysis of data Statistics Surveillance Surveys |
| title | Validation of a scale for assessing attitudes towards outcomes of genetic cancer testing among primary care providers and breast specialists |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T18%3A05%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Validation%20of%20a%20scale%20for%20assessing%20attitudes%20towards%20outcomes%20of%20genetic%20cancer%20testing%20among%20primary%20care%20providers%20and%20breast%20specialists&rft.jtitle=PloS%20one&rft.au=Bouhnik,%20Anne-Deborah&rft.date=2017-06-01&rft.volume=12&rft.issue=6&rft.spage=e0178447&rft.epage=e0178447&rft.pages=e0178447-e0178447&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0178447&rft_dat=%3Cgale_plos_%3EA493876593%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1904975737&rft_id=info:pmid/28570656&rft_galeid=A493876593&rft_doaj_id=oai_doaj_org_article_af5fbf67df0c4eaf9c49ad84d9d1dcdc&rfr_iscdi=true |