ADAMTS-1 in abdominal aortic aneurysm

Extracellular matrix degradation is a hallmark of abdominal aortic aneurysm (AAA). Among proteases that are capable of degrading extracellular matrix are a disintegrin and metalloproteases with thrombospondin motifs (ADAMTS). Pathogenesis of these proteases in AAA has not been investigated until dat...

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Veröffentlicht in:	PloS one 2017-06, Vol.12 (6), p.e0178729-e0178729
Hauptverfasser:	Vorkapic, Emina, Folkesson, Maggie, Magnell, Kerstin, Bohlooly-Y, Mohammad, Länne, Toste, Wågsäter, Dick
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdomen Abdominal aortic aneurysm ADAMTS-1 protein ADAMTS1 Protein - metabolism Aneurysms Angiotensin Angiotensin II Animals Aorta Aortic Aneurysm, Abdominal - metabolism Aortic aneurysms Apolipoprotein E Arteriosclerosis Atherosclerosis Biology and Life Sciences Biopsy Blood clots Collagen Confidence intervals Coronary vessels Degradation Disease control Elastin Enzymes Ethics Extracellular matrix Gene expression Health sciences Histology Humans Immunohistochemistry Inflammation Localization Low density lipoprotein receptors Macrophages Male Medicine and Health Sciences Mice mRNA Pathogenesis Polymerase chain reaction Protease inhibitors Proteins R&D Research & development Rodents Smooth muscle Substrates Thorax Thrombospondin Transgenic mice
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