A retrospective observational study of glucocorticoid-induced diabetes mellitus with IgA nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy
To evaluate the incidence of GC-DM among patients with immunoglobulin A nephropathy (IgAN) and to confirm the risk factors for the development of GC-DM. The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The p...
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| Veröffentlicht in: | PloS one 2017-05, Vol.12 (5), p.e0178018-e0178018 |
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| creator | Miyawaki, Yoshia Katsuyama, Takayuki Sada, Ken-Ei Hiramatsu, Sumie Ohashi, Keiji Morishita, Michiko Katsuyama, Eri Watanabe, Haruki Takano-Narazaki, Mariko Toyota-Tatebe, Noriko Sunahori-Watanabe, Katsue Kawabata, Tomoko Inoue, Tatsuyuki Kinomura, Masaru Sugiyama, Hitoshi Wada, Jun |
| description | To evaluate the incidence of GC-DM among patients with immunoglobulin A nephropathy (IgAN) and to confirm the risk factors for the development of GC-DM.
The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The primary outcome was the development of GC-DM within the hospitalization period and during one year of follow-up.
During hospitalization, 19 of the 95 patients developed GC-DM (20.0%), and the patients with GC-DM were significantly older and had a higher rate of family history of diabetes and higher HbA1c levels. The prevalence of hypertension was higher and the eGFR was numerically lower in patients with GC-DM than in those without. Older age (≥45 years) and a family history of diabetes emerged as independent risk factors for the development of GC-DM (odds ratio [OR], 6.3 and 95% confidence interval [CI], 1.6-27.6; OR, 4.4 and 95% CI, 1.2-16.6, respectively). No patients were newly diagnosed with GC-DM during 1-year observation period at out-patient clinic.
Among the patients with IgAN, 20% developed GC-DM during the hospitalization period, confirming the family history of diabetes is clinically necessary before starting GC therapy. |
| doi_str_mv | 10.1371/journal.pone.0178018 |
| format | Article |
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The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The primary outcome was the development of GC-DM within the hospitalization period and during one year of follow-up.
During hospitalization, 19 of the 95 patients developed GC-DM (20.0%), and the patients with GC-DM were significantly older and had a higher rate of family history of diabetes and higher HbA1c levels. The prevalence of hypertension was higher and the eGFR was numerically lower in patients with GC-DM than in those without. Older age (≥45 years) and a family history of diabetes emerged as independent risk factors for the development of GC-DM (odds ratio [OR], 6.3 and 95% confidence interval [CI], 1.6-27.6; OR, 4.4 and 95% CI, 1.2-16.6, respectively). No patients were newly diagnosed with GC-DM during 1-year observation period at out-patient clinic.
Among the patients with IgAN, 20% developed GC-DM during the hospitalization period, confirming the family history of diabetes is clinically necessary before starting GC therapy.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0178018</identifier><identifier>PMID: 28562629</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age ; Biology and life sciences ; Biopsy ; Care and treatment ; Clinical medicine ; Dentistry ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - chemically induced ; Dosage and administration ; Drug dosages ; Drug therapy ; Endocrinology ; Epidermal growth factor receptors ; Family medical history ; Female ; Genetics ; Geriatrics ; Glomerulonephritis, IGA - complications ; Glomerulonephritis, IGA - drug therapy ; Glomerulonephritis, IGA - surgery ; Glucocorticoids ; Glucose ; Health risk assessment ; Hemoglobin ; Humans ; Hypertension ; Hypoglycemia ; IgA nephropathy ; Immunoglobulin A ; Incidence ; Insulin resistance ; Kidney diseases ; Male ; Medical prognosis ; Medical records ; Medicine ; Medicine and Health Sciences ; Metabolism ; Methylprednisolone ; Methylprednisolone - adverse effects ; Methylprednisolone - therapeutic use ; Nephrology ; Obesity ; Observational studies ; Patients ; Pharmaceutical sciences ; Pharmaceuticals ; Retrospective Studies ; Rheumatic diseases ; Rheumatoid arthritis ; Rheumatology ; Risk analysis ; Risk factors ; Therapy ; Tonsillectomy ; Transplants & implants ; University graduates ; Young Adult</subject><ispartof>PloS one, 2017-05, Vol.12 (5), p.e0178018-e0178018</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Miyawaki et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Miyawaki et al 2017 Miyawaki et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-ea0f7f164dcd4857c4b9d45cba70f4173f2faa374ee3abc1ec9d8cc6dcdb0ce3</citedby><cites>FETCH-LOGICAL-c692t-ea0f7f164dcd4857c4b9d45cba70f4173f2faa374ee3abc1ec9d8cc6dcdb0ce3</cites><orcidid>0000-0002-6981-3443</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451026/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451026/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28562629$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyawaki, Yoshia</creatorcontrib><creatorcontrib>Katsuyama, Takayuki</creatorcontrib><creatorcontrib>Sada, Ken-Ei</creatorcontrib><creatorcontrib>Hiramatsu, Sumie</creatorcontrib><creatorcontrib>Ohashi, Keiji</creatorcontrib><creatorcontrib>Morishita, Michiko</creatorcontrib><creatorcontrib>Katsuyama, Eri</creatorcontrib><creatorcontrib>Watanabe, Haruki</creatorcontrib><creatorcontrib>Takano-Narazaki, Mariko</creatorcontrib><creatorcontrib>Toyota-Tatebe, Noriko</creatorcontrib><creatorcontrib>Sunahori-Watanabe, Katsue</creatorcontrib><creatorcontrib>Kawabata, Tomoko</creatorcontrib><creatorcontrib>Inoue, Tatsuyuki</creatorcontrib><creatorcontrib>Kinomura, Masaru</creatorcontrib><creatorcontrib>Sugiyama, Hitoshi</creatorcontrib><creatorcontrib>Wada, Jun</creatorcontrib><title>A retrospective observational study of glucocorticoid-induced diabetes mellitus with IgA nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To evaluate the incidence of GC-DM among patients with immunoglobulin A nephropathy (IgAN) and to confirm the risk factors for the development of GC-DM.
The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The primary outcome was the development of GC-DM within the hospitalization period and during one year of follow-up.
During hospitalization, 19 of the 95 patients developed GC-DM (20.0%), and the patients with GC-DM were significantly older and had a higher rate of family history of diabetes and higher HbA1c levels. The prevalence of hypertension was higher and the eGFR was numerically lower in patients with GC-DM than in those without. Older age (≥45 years) and a family history of diabetes emerged as independent risk factors for the development of GC-DM (odds ratio [OR], 6.3 and 95% confidence interval [CI], 1.6-27.6; OR, 4.4 and 95% CI, 1.2-16.6, respectively). No patients were newly diagnosed with GC-DM during 1-year observation period at out-patient clinic.
Among the patients with IgAN, 20% developed GC-DM during the hospitalization period, confirming the family history of diabetes is clinically necessary before starting GC therapy.</description><subject>Adult</subject><subject>Age</subject><subject>Biology and life sciences</subject><subject>Biopsy</subject><subject>Care and treatment</subject><subject>Clinical medicine</subject><subject>Dentistry</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - chemically induced</subject><subject>Dosage and administration</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Endocrinology</subject><subject>Epidermal growth factor receptors</subject><subject>Family medical history</subject><subject>Female</subject><subject>Genetics</subject><subject>Geriatrics</subject><subject>Glomerulonephritis, IGA - complications</subject><subject>Glomerulonephritis, IGA - drug therapy</subject><subject>Glomerulonephritis, IGA - surgery</subject><subject>Glucocorticoids</subject><subject>Glucose</subject><subject>Health risk assessment</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypoglycemia</subject><subject>IgA nephropathy</subject><subject>Immunoglobulin A</subject><subject>Incidence</subject><subject>Insulin resistance</subject><subject>Kidney diseases</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical records</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Methylprednisolone</subject><subject>Methylprednisolone - adverse effects</subject><subject>Methylprednisolone - therapeutic use</subject><subject>Nephrology</subject><subject>Obesity</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Pharmaceutical sciences</subject><subject>Pharmaceuticals</subject><subject>Retrospective Studies</subject><subject>Rheumatic diseases</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatology</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Therapy</subject><subject>Tonsillectomy</subject><subject>Transplants & implants</subject><subject>University graduates</subject><subject>Young 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retrospective observational study of glucocorticoid-induced diabetes mellitus with IgA nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy</title><author>Miyawaki, Yoshia ; Katsuyama, Takayuki ; Sada, Ken-Ei ; Hiramatsu, Sumie ; Ohashi, Keiji ; Morishita, Michiko ; Katsuyama, Eri ; Watanabe, Haruki ; Takano-Narazaki, Mariko ; Toyota-Tatebe, Noriko ; Sunahori-Watanabe, Katsue ; Kawabata, Tomoko ; Inoue, Tatsuyuki ; Kinomura, Masaru ; Sugiyama, Hitoshi ; Wada, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-ea0f7f164dcd4857c4b9d45cba70f4173f2faa374ee3abc1ec9d8cc6dcdb0ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Age</topic><topic>Biology and life sciences</topic><topic>Biopsy</topic><topic>Care and treatment</topic><topic>Clinical medicine</topic><topic>Dentistry</topic><topic>Diabetes</topic><topic>Diabetes 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Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyawaki, Yoshia</au><au>Katsuyama, Takayuki</au><au>Sada, Ken-Ei</au><au>Hiramatsu, Sumie</au><au>Ohashi, Keiji</au><au>Morishita, Michiko</au><au>Katsuyama, Eri</au><au>Watanabe, Haruki</au><au>Takano-Narazaki, Mariko</au><au>Toyota-Tatebe, Noriko</au><au>Sunahori-Watanabe, Katsue</au><au>Kawabata, Tomoko</au><au>Inoue, Tatsuyuki</au><au>Kinomura, Masaru</au><au>Sugiyama, Hitoshi</au><au>Wada, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A retrospective observational study of glucocorticoid-induced diabetes mellitus with IgA nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-05-31</date><risdate>2017</risdate><volume>12</volume><issue>5</issue><spage>e0178018</spage><epage>e0178018</epage><pages>e0178018-e0178018</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To evaluate the incidence of GC-DM among patients with immunoglobulin A nephropathy (IgAN) and to confirm the risk factors for the development of GC-DM.
The medical records of patients with IgAN newly treated with the protocol of tonsillectomy combined with steroid pulse therapy were reviewed. The primary outcome was the development of GC-DM within the hospitalization period and during one year of follow-up.
During hospitalization, 19 of the 95 patients developed GC-DM (20.0%), and the patients with GC-DM were significantly older and had a higher rate of family history of diabetes and higher HbA1c levels. The prevalence of hypertension was higher and the eGFR was numerically lower in patients with GC-DM than in those without. Older age (≥45 years) and a family history of diabetes emerged as independent risk factors for the development of GC-DM (odds ratio [OR], 6.3 and 95% confidence interval [CI], 1.6-27.6; OR, 4.4 and 95% CI, 1.2-16.6, respectively). No patients were newly diagnosed with GC-DM during 1-year observation period at out-patient clinic.
Among the patients with IgAN, 20% developed GC-DM during the hospitalization period, confirming the family history of diabetes is clinically necessary before starting GC therapy.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28562629</pmid><doi>10.1371/journal.pone.0178018</doi><tpages>e0178018</tpages><orcidid>https://orcid.org/0000-0002-6981-3443</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-05, Vol.12 (5), p.e0178018-e0178018 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1904767584 |
| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Age Biology and life sciences Biopsy Care and treatment Clinical medicine Dentistry Diabetes Diabetes mellitus Diabetes Mellitus - chemically induced Dosage and administration Drug dosages Drug therapy Endocrinology Epidermal growth factor receptors Family medical history Female Genetics Geriatrics Glomerulonephritis, IGA - complications Glomerulonephritis, IGA - drug therapy Glomerulonephritis, IGA - surgery Glucocorticoids Glucose Health risk assessment Hemoglobin Humans Hypertension Hypoglycemia IgA nephropathy Immunoglobulin A Incidence Insulin resistance Kidney diseases Male Medical prognosis Medical records Medicine Medicine and Health Sciences Metabolism Methylprednisolone Methylprednisolone - adverse effects Methylprednisolone - therapeutic use Nephrology Obesity Observational studies Patients Pharmaceutical sciences Pharmaceuticals Retrospective Studies Rheumatic diseases Rheumatoid arthritis Rheumatology Risk analysis Risk factors Therapy Tonsillectomy Transplants & implants University graduates Young Adult |
| title | A retrospective observational study of glucocorticoid-induced diabetes mellitus with IgA nephropathy treated with tonsillectomy plus methylprednisolone pulse therapy |
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