Doxycycline potentiates antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy in malignant peripheral nerve sheath tumor cells

Neurofibromatosis type 1 (NF1) is one of the most common neurocutaneous disorders. Some NF1 patients develop benign large plexiform neurofibroma(s) at birth, which can then transform into a malignant peripheral nerve sheath tumor (MPNST). There is no curative treatment for this rapidly progressive a...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0178493
Hauptverfasser:	Lee, Ming-Jen, Hung, Shih-Hsuan, Huang, Mu-Ching, Tsai, Tsuimin, Chen, Chin-Tin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aminolevulinic acid Aminolevulinic Acid - pharmacology Animal models Animals Antibiotics Antibiotics, Antineoplastic - pharmacology Anticancer properties Antitumor activity Apoptosis Benign Biocompatibility Biology and Life Sciences Biotechnology Cancer Cell death Cell Line, Tumor Cell survival Clinical trials Combined treatment Complications and side effects Cytotoxicity Disease Disorders Dosage and administration Doxycycline Doxycycline - pharmacology Drug therapy Enzymes Ferrochelatase Fibroblasts Genetic disorders Humans Hydroxymethylbilane synthase Laboratories Medicine and Health Sciences Metastases Minocycline Morbidity Neoplasia Neoplasms Nervous system tumors Neurilemmoma - pathology Neurofibromatosis Neurological disorders Oral cancer Phenols Photochemotherapy Photodynamic therapy Photosensitizing Agents - pharmacology Plexiform neurofibroma Protein synthesis Protoporphyrin Protoporphyrin IX Radiation Recklinghausen's disease Research and Analysis Methods Side effects Skin Survival Synergistic effect Tumor cell lines Tumor cells Tumors
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