Is survival improved by the use of NIV and PEG in amyotrophic lateral sclerosis (ALS)? A post-mortem study of 80 ALS patients

Non-invasive ventilation (NIV) and percutaneous gastrostomy (PEG) are guideline-recommended interventions for symptom management in amyotrophic lateral sclerosis (ALS). Their effect on survival is controversial and the impact on causes of death is unknown. To investigate the effect of NIV and PEG on...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0177555-e0177555
Hauptverfasser:	Burkhardt, Christian, Neuwirth, Christoph, Sommacal, Andreas, Andersen, Peter M, Weber, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - complications Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - mortality Amyotrophic Lateral Sclerosis - therapy Analysis Assisted suicide Biological markers Bronchopneumonia C9orf72 Protein Care and treatment Cause of Death Death Dementia Development and progression Disease Disease Progression Embolism Embolisms Epidemiology Failure analysis Female Gastrostomy Genetic screening Health risk assessment Health risks Humans Hypoxia Male Mechanical ventilation Medical diagnosis Medicine and Health Sciences Middle Aged Multivariate Analysis Neurology Neuromuscular diseases Noninvasive Ventilation Nuclear Respiratory Factors Ostomy Patient outcomes Patients Pneumonia Polyethylene glycol Proportional Hazards Models Proteins - genetics Psychiatry Pulmonary embolisms Regression analysis Respiratory failure Retrospective Studies Suicide Survival Survival Analysis Symptom management Ventilation
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