The role of the innate immune response regulatory gene ABCF1 in mammalian embryogenesis and development

ABCF1 is an ABC transporter family protein that has been shown to regulate innate immune response and is a risk gene for autoimmune pancreatitis and arthritis. Unlike other members of ABC transporter family, ABCF1 lacks trans-membrane domains and is thought to function in translation initiation thro...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0175918-e0175918
Hauptverfasser:	Wilcox, Sara M, Arora, Hitesh, Munro, Lonna, Xin, Jian, Fenninger, Franz, Johnson, Laura A, Pfeifer, Cheryl G, Choi, Kyung Bok, Hou, Juan, Hoodless, Pamela A, Jefferies, Wilfred A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adults Analysis Anatomy Animal tissues Animals Arthritis ATP (Adenosine triphosphate) ATP-Binding Cassette Transporters - deficiency ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism Biology and Life Sciences Care and treatment Cell Differentiation Cell Line Cell Proliferation Embryo, Mammalian - embryology Embryo, Mammalian - immunology Embryology Embryonic Development Embryonic growth stage Embryos Galactosidase Gene expression Gene Expression Regulation, Developmental Gene Knockout Techniques Genes Immune response Immune system Immunity, Innate Immunology Initiation factor eIF-2 Innate immunity Lethality Mice Organs Pancreatitis Progeny Promoter Regions, Genetic - genetics Proteins Research and Analysis Methods Rodents Stem cells β-Galactosidase
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