Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes
Perimetry is indispensable for the clinical management of glaucoma suspects. Our goal is to compare the performance of standard automated perimetry (SAP) and Matrix frequency-doubling technology (FDT) perimetry in monitoring the development of visual field (VF) defects in glaucoma suspect eyes. Long...
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| description | Perimetry is indispensable for the clinical management of glaucoma suspects. Our goal is to compare the performance of standard automated perimetry (SAP) and Matrix frequency-doubling technology (FDT) perimetry in monitoring the development of visual field (VF) defects in glaucoma suspect eyes.
Longitudinal data of paired SAP and FDT from 221 eyes of 155 glaucoma suspects enrolled in the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study were included. All eyes had glaucomatous optic neuropathy or ocular hypertension, but normal SAP and FDT results at baseline. The development of glaucomatous VF defects was defined as the presence of a cluster of ≥ 3 (less conservative) or ≥ 4 (more conservative) locations confirmed on ≥ 2 additional consecutive tests. Risk factors for the development of VF defects were analyzed by COX proportional hazard models. After conversion into common logarithmic units, the rates of change of global VF indices were fitted with linear mixed models.
FDT detected more eyes that developed VF defects than SAP using the less conservative criterion, and no significant difference was observed using the more conservative criterion. For those eyes detected by both SAP and FDT, FDT detected the development of VF defects either earlier than SAP or simultaneously in most cases. Baseline structural measurements were not significantly associated with an increased risk for the development of glaucomatous VF defects on either SAP or FDT. Older age was significantly associated with the development of VF defects on FDT but not on SAP. Both SAP and FDT detected a progressing worsening trend of pattern standard deviation over time with a similar rate of change between these test types.
Matrix FDT would be useful to monitor the onset of VF defects in glaucoma suspects and may outperform SAP in the early stage of glaucomatous VF damage. |
| doi_str_mv | 10.1371/journal.pone.0178079 |
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Longitudinal data of paired SAP and FDT from 221 eyes of 155 glaucoma suspects enrolled in the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study were included. All eyes had glaucomatous optic neuropathy or ocular hypertension, but normal SAP and FDT results at baseline. The development of glaucomatous VF defects was defined as the presence of a cluster of ≥ 3 (less conservative) or ≥ 4 (more conservative) locations confirmed on ≥ 2 additional consecutive tests. Risk factors for the development of VF defects were analyzed by COX proportional hazard models. After conversion into common logarithmic units, the rates of change of global VF indices were fitted with linear mixed models.
FDT detected more eyes that developed VF defects than SAP using the less conservative criterion, and no significant difference was observed using the more conservative criterion. For those eyes detected by both SAP and FDT, FDT detected the development of VF defects either earlier than SAP or simultaneously in most cases. Baseline structural measurements were not significantly associated with an increased risk for the development of glaucomatous VF defects on either SAP or FDT. Older age was significantly associated with the development of VF defects on FDT but not on SAP. Both SAP and FDT detected a progressing worsening trend of pattern standard deviation over time with a similar rate of change between these test types.
Matrix FDT would be useful to monitor the onset of VF defects in glaucoma suspects and may outperform SAP in the early stage of glaucomatous VF damage.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0178079</identifier><identifier>PMID: 28542536</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age Factors ; Aged ; Assessment centers ; Automation ; Biology and Life Sciences ; Care and treatment ; Criteria ; Defects ; Diagnosis ; Diagnostic systems ; Disease prevention ; Eye (anatomy) ; Female ; Glaucoma ; Glaucoma - diagnosis ; Glaucoma - physiopathology ; Health aspects ; Humans ; Hypertension ; Influence ; Male ; Medicine and Health Sciences ; Middle Aged ; Monitoring ; Neuropathy ; Ocular Hypertension - physiopathology ; Optic neuropathy ; Perimetry ; Physical Sciences ; Proportional Hazards Models ; Research and Analysis Methods ; Risk analysis ; Risk Factors ; SAP protein ; Social Sciences ; Studies ; Visual field ; Visual Field Tests ; Visual fields ; Visual perception</subject><ispartof>PloS one, 2017-05, Vol.12 (5), p.e0178079-e0178079</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Hu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Hu et al 2017 Hu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-81c8eb9e062380ca49db2faa6f0ef78af1258e2925d1354eaa7a0d72118fc9e83</citedby><cites>FETCH-LOGICAL-c692t-81c8eb9e062380ca49db2faa6f0ef78af1258e2925d1354eaa7a0d72118fc9e83</cites><orcidid>0000-0002-2238-3431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436878/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436878/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2106,2932,23875,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28542536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bhattacharya, Sanjoy</contributor><creatorcontrib>Hu, Rongrong</creatorcontrib><creatorcontrib>Wang, Chenkun</creatorcontrib><creatorcontrib>Racette, Lyne</creatorcontrib><title>Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Perimetry is indispensable for the clinical management of glaucoma suspects. Our goal is to compare the performance of standard automated perimetry (SAP) and Matrix frequency-doubling technology (FDT) perimetry in monitoring the development of visual field (VF) defects in glaucoma suspect eyes.
Longitudinal data of paired SAP and FDT from 221 eyes of 155 glaucoma suspects enrolled in the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study were included. All eyes had glaucomatous optic neuropathy or ocular hypertension, but normal SAP and FDT results at baseline. The development of glaucomatous VF defects was defined as the presence of a cluster of ≥ 3 (less conservative) or ≥ 4 (more conservative) locations confirmed on ≥ 2 additional consecutive tests. Risk factors for the development of VF defects were analyzed by COX proportional hazard models. After conversion into common logarithmic units, the rates of change of global VF indices were fitted with linear mixed models.
FDT detected more eyes that developed VF defects than SAP using the less conservative criterion, and no significant difference was observed using the more conservative criterion. For those eyes detected by both SAP and FDT, FDT detected the development of VF defects either earlier than SAP or simultaneously in most cases. Baseline structural measurements were not significantly associated with an increased risk for the development of glaucomatous VF defects on either SAP or FDT. Older age was significantly associated with the development of VF defects on FDT but not on SAP. Both SAP and FDT detected a progressing worsening trend of pattern standard deviation over time with a similar rate of change between these test types.
Matrix FDT would be useful to monitor the onset of VF defects in glaucoma suspects and may outperform SAP in the early stage of glaucomatous VF damage.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Assessment centers</subject><subject>Automation</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Criteria</subject><subject>Defects</subject><subject>Diagnosis</subject><subject>Diagnostic systems</subject><subject>Disease prevention</subject><subject>Eye (anatomy)</subject><subject>Female</subject><subject>Glaucoma</subject><subject>Glaucoma - diagnosis</subject><subject>Glaucoma - physiopathology</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Influence</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Monitoring</subject><subject>Neuropathy</subject><subject>Ocular Hypertension - physiopathology</subject><subject>Optic neuropathy</subject><subject>Perimetry</subject><subject>Physical Sciences</subject><subject>Proportional Hazards Models</subject><subject>Research and Analysis Methods</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>SAP protein</subject><subject>Social Sciences</subject><subject>Studies</subject><subject>Visual field</subject><subject>Visual Field Tests</subject><subject>Visual fields</subject><subject>Visual 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One</addtitle><date>2017-05-18</date><risdate>2017</risdate><volume>12</volume><issue>5</issue><spage>e0178079</spage><epage>e0178079</epage><pages>e0178079-e0178079</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Perimetry is indispensable for the clinical management of glaucoma suspects. Our goal is to compare the performance of standard automated perimetry (SAP) and Matrix frequency-doubling technology (FDT) perimetry in monitoring the development of visual field (VF) defects in glaucoma suspect eyes.
Longitudinal data of paired SAP and FDT from 221 eyes of 155 glaucoma suspects enrolled in the Diagnostic Innovations in Glaucoma Study or the African Descent and Glaucoma Evaluation Study were included. All eyes had glaucomatous optic neuropathy or ocular hypertension, but normal SAP and FDT results at baseline. The development of glaucomatous VF defects was defined as the presence of a cluster of ≥ 3 (less conservative) or ≥ 4 (more conservative) locations confirmed on ≥ 2 additional consecutive tests. Risk factors for the development of VF defects were analyzed by COX proportional hazard models. After conversion into common logarithmic units, the rates of change of global VF indices were fitted with linear mixed models.
FDT detected more eyes that developed VF defects than SAP using the less conservative criterion, and no significant difference was observed using the more conservative criterion. For those eyes detected by both SAP and FDT, FDT detected the development of VF defects either earlier than SAP or simultaneously in most cases. Baseline structural measurements were not significantly associated with an increased risk for the development of glaucomatous VF defects on either SAP or FDT. Older age was significantly associated with the development of VF defects on FDT but not on SAP. Both SAP and FDT detected a progressing worsening trend of pattern standard deviation over time with a similar rate of change between these test types.
Matrix FDT would be useful to monitor the onset of VF defects in glaucoma suspects and may outperform SAP in the early stage of glaucomatous VF damage.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28542536</pmid><doi>10.1371/journal.pone.0178079</doi><tpages>e0178079</tpages><orcidid>https://orcid.org/0000-0002-2238-3431</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Aged Assessment centers Automation Biology and Life Sciences Care and treatment Criteria Defects Diagnosis Diagnostic systems Disease prevention Eye (anatomy) Female Glaucoma Glaucoma - diagnosis Glaucoma - physiopathology Health aspects Humans Hypertension Influence Male Medicine and Health Sciences Middle Aged Monitoring Neuropathy Ocular Hypertension - physiopathology Optic neuropathy Perimetry Physical Sciences Proportional Hazards Models Research and Analysis Methods Risk analysis Risk Factors SAP protein Social Sciences Studies Visual field Visual Field Tests Visual fields Visual perception |
| title | Comparison of matrix frequency-doubling technology perimetry and standard automated perimetry in monitoring the development of visual field defects for glaucoma suspect eyes |
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