The toxic effects and possible mechanisms of Brusatol on mouse oocytes

Brusatol is a natural quassinoid that shows a potential therapeutic use in cancer models by the inhibition of Nuclear factor erythroid 2-related factor 2 (Nrf2) and is capable of inducing a variety of biological effects. The effects of Brusatol on oocyte meiosis has not been addressed. In this study...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0177844-e0177844
Hauptverfasser:	Ma, Rujun, Li, Hongru, Zhang, Yu, Lin, Ying, Qiu, Xuhua, Xie, Min, Yao, Bing
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal models Animals Apoptosis Biological effects Biology Biology and Life Sciences Cancer Chromosomes, Mammalian - drug effects Chromosomes, Mammalian - metabolism Cyclin B1 Cyclin B1 - metabolism Cyclins Female Free radicals Health aspects Hospitals Laboratory animals Mammals Maturation Medicine Meiosis Meiosis - drug effects Mice Mice, Inbred ICR Mitochondria - drug effects Mitochondria - metabolism mRNA NF-E2-Related Factor 2 - metabolism Oocytes Oocytes - cytology Oocytes - drug effects Oocytes - metabolism Oxidative stress Oxidative Stress - drug effects Physical Sciences Quassins - toxicity Reproductive health Research and Analysis Methods RNA Spindle Apparatus - drug effects Spindle Apparatus - metabolism Toxicity Yu Zhang
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