Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China
Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk c...
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| Veröffentlicht in: | PloS one 2017-05, Vol.12 (5), p.e0177504-e0177504 |
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| description | Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population.
A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China. Five milliliters of blood were collected from all subjects for genotyping. Genotyping of 20 high-risk SNP loci identified from genome-wide association studies (GWAS) on esophageal, lung and gastric cancers was performed using TaqMan allelic discrimination assays. Polymorphisms were examined for deviation from Hardy-Weinberg equilibrium (HWE) using Х2 test. Bonferroni correction was performed to correct the statistical significance of 20 SNPs with the risk of lung cancer. The Pearson's Х2 test was used to compare the distributions of gender, TNM stage, histopathological type, smoking and family history by lung susceptibility genotypes. Kaplan-Meier and Cox regression analyses were carried out to evaluate the associations between genetic variants and overall survival.
Four of the 20 SNPs identified as high-risk SNPs in Chinese esophageal cancer showed increased risk for Chinese lung cancer, which included rs3769823 (OR = 1.26; 95% CI = 1.107-1.509; P = 0.02), rs10931936 (OR = 1.283; 95% CI = 1.100-1.495; P = 0.04), rs2244438 (OR = 1.294; 95% CI = 1.098-1.525; P = 0.04) and rs13016963 (OR = 1.268; 95% CI = 1.089-1.447; P = 0.04). All these SNPs were located at 2q33 region harboringgenes of CASP8, ALS2CR12 and TRAK2. However, none of these susceptibility SNPs was observed to be significantly associated with gender, TNM stage, histopathological type, smoking, family history and overall survival.
The present study identified four high-risk SNPs at 2q33 locus for Chinese lung cancer and demonstrated the shared susceptibility loci at 2q33 region for Chinese lung and esophageal cancers. |
| doi_str_mv | 10.1371/journal.pone.0177504 |
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A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China. Five milliliters of blood were collected from all subjects for genotyping. Genotyping of 20 high-risk SNP loci identified from genome-wide association studies (GWAS) on esophageal, lung and gastric cancers was performed using TaqMan allelic discrimination assays. Polymorphisms were examined for deviation from Hardy-Weinberg equilibrium (HWE) using Х2 test. Bonferroni correction was performed to correct the statistical significance of 20 SNPs with the risk of lung cancer. The Pearson's Х2 test was used to compare the distributions of gender, TNM stage, histopathological type, smoking and family history by lung susceptibility genotypes. Kaplan-Meier and Cox regression analyses were carried out to evaluate the associations between genetic variants and overall survival.
Four of the 20 SNPs identified as high-risk SNPs in Chinese esophageal cancer showed increased risk for Chinese lung cancer, which included rs3769823 (OR = 1.26; 95% CI = 1.107-1.509; P = 0.02), rs10931936 (OR = 1.283; 95% CI = 1.100-1.495; P = 0.04), rs2244438 (OR = 1.294; 95% CI = 1.098-1.525; P = 0.04) and rs13016963 (OR = 1.268; 95% CI = 1.089-1.447; P = 0.04). All these SNPs were located at 2q33 region harboringgenes of CASP8, ALS2CR12 and TRAK2. However, none of these susceptibility SNPs was observed to be significantly associated with gender, TNM stage, histopathological type, smoking, family history and overall survival.
The present study identified four high-risk SNPs at 2q33 locus for Chinese lung cancer and demonstrated the shared susceptibility loci at 2q33 region for Chinese lung and esophageal cancers.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0177504</identifier><identifier>PMID: 28542283</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Breast cancer ; Case-Control Studies ; China - epidemiology ; Chromosome 2 ; Deoxyribonucleic acid ; Disease susceptibility ; DNA ; Esophageal cancer ; Esophageal Neoplasms - diagnosis ; Esophageal Neoplasms - epidemiology ; Esophageal Neoplasms - genetics ; Esophagus ; Family medical history ; Female ; Genetic aspects ; Genetic Loci - genetics ; Genetic Predisposition to Disease - genetics ; Genetic testing ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Genomics ; Genotyping ; Health aspects ; Humans ; Incidence ; Laboratories ; Lung cancer ; Lung diseases ; Lung Neoplasms - diagnosis ; Lung Neoplasms - genetics ; Male ; Medical prognosis ; Medical research ; Medicine and Health Sciences ; Middle Aged ; People and Places ; Polymorphism ; Polymorphism, Single Nucleotide ; Population ; Prognosis ; Risk factors ; Single-nucleotide polymorphism ; Smoking ; Studies ; Survival ; Survival Analysis</subject><ispartof>PloS one, 2017-05, Vol.12 (5), p.e0177504-e0177504</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Zhao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Zhao et al 2017 Zhao et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-3c1a69a820ab01937d46966d93778f6dd3a8cce24c2e7e5a8aa8d9a28965bca63</citedby><cites>FETCH-LOGICAL-c692t-3c1a69a820ab01937d46966d93778f6dd3a8cce24c2e7e5a8aa8d9a28965bca63</cites><orcidid>0000-0002-7933-0410</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436667/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5436667/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27904,27905,53771,53773,79348,79349</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28542283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Wei, Qingyi</contributor><creatorcontrib>Zhao, Xue Ke</creatorcontrib><creatorcontrib>Mao, Yi Min</creatorcontrib><creatorcontrib>Meng, Hui</creatorcontrib><creatorcontrib>Song, Xin</creatorcontrib><creatorcontrib>Hu, Shou Jia</creatorcontrib><creatorcontrib>Lv, Shuang</creatorcontrib><creatorcontrib>Cheng, Rang</creatorcontrib><creatorcontrib>Zhang, Tang Juan</creatorcontrib><creatorcontrib>Han, Xue Na</creatorcontrib><creatorcontrib>Ren, Jing Li</creatorcontrib><creatorcontrib>Qi, Yi Jun</creatorcontrib><creatorcontrib>Wang, Li Dong</creatorcontrib><title>Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population.
A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China. Five milliliters of blood were collected from all subjects for genotyping. Genotyping of 20 high-risk SNP loci identified from genome-wide association studies (GWAS) on esophageal, lung and gastric cancers was performed using TaqMan allelic discrimination assays. Polymorphisms were examined for deviation from Hardy-Weinberg equilibrium (HWE) using Х2 test. Bonferroni correction was performed to correct the statistical significance of 20 SNPs with the risk of lung cancer. The Pearson's Х2 test was used to compare the distributions of gender, TNM stage, histopathological type, smoking and family history by lung susceptibility genotypes. Kaplan-Meier and Cox regression analyses were carried out to evaluate the associations between genetic variants and overall survival.
Four of the 20 SNPs identified as high-risk SNPs in Chinese esophageal cancer showed increased risk for Chinese lung cancer, which included rs3769823 (OR = 1.26; 95% CI = 1.107-1.509; P = 0.02), rs10931936 (OR = 1.283; 95% CI = 1.100-1.495; P = 0.04), rs2244438 (OR = 1.294; 95% CI = 1.098-1.525; P = 0.04) and rs13016963 (OR = 1.268; 95% CI = 1.089-1.447; P = 0.04). All these SNPs were located at 2q33 region harboringgenes of CASP8, ALS2CR12 and TRAK2. However, none of these susceptibility SNPs was observed to be significantly associated with gender, TNM stage, histopathological type, smoking, family history and overall survival.
The present study identified four high-risk SNPs at 2q33 locus for Chinese lung cancer and demonstrated the shared susceptibility loci at 2q33 region for Chinese lung and esophageal cancers.</description><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Breast cancer</subject><subject>Case-Control Studies</subject><subject>China - epidemiology</subject><subject>Chromosome 2</subject><subject>Deoxyribonucleic acid</subject><subject>Disease susceptibility</subject><subject>DNA</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - diagnosis</subject><subject>Esophageal Neoplasms - epidemiology</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophagus</subject><subject>Family medical history</subject><subject>Female</subject><subject>Genetic aspects</subject><subject>Genetic Loci - genetics</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic testing</subject><subject>Genome-wide association studies</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Genotyping</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Incidence</subject><subject>Laboratories</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - genetics</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>People and Places</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Population</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>Single-nucleotide polymorphism</subject><subject>Smoking</subject><subject>Studies</subject><subject>Survival</subject><subject>Survival 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Qingyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-05-18</date><risdate>2017</risdate><volume>12</volume><issue>5</issue><spage>e0177504</spage><epage>e0177504</epage><pages>e0177504-e0177504</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population.
A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China. Five milliliters of blood were collected from all subjects for genotyping. Genotyping of 20 high-risk SNP loci identified from genome-wide association studies (GWAS) on esophageal, lung and gastric cancers was performed using TaqMan allelic discrimination assays. Polymorphisms were examined for deviation from Hardy-Weinberg equilibrium (HWE) using Х2 test. Bonferroni correction was performed to correct the statistical significance of 20 SNPs with the risk of lung cancer. The Pearson's Х2 test was used to compare the distributions of gender, TNM stage, histopathological type, smoking and family history by lung susceptibility genotypes. Kaplan-Meier and Cox regression analyses were carried out to evaluate the associations between genetic variants and overall survival.
Four of the 20 SNPs identified as high-risk SNPs in Chinese esophageal cancer showed increased risk for Chinese lung cancer, which included rs3769823 (OR = 1.26; 95% CI = 1.107-1.509; P = 0.02), rs10931936 (OR = 1.283; 95% CI = 1.100-1.495; P = 0.04), rs2244438 (OR = 1.294; 95% CI = 1.098-1.525; P = 0.04) and rs13016963 (OR = 1.268; 95% CI = 1.089-1.447; P = 0.04). All these SNPs were located at 2q33 region harboringgenes of CASP8, ALS2CR12 and TRAK2. However, none of these susceptibility SNPs was observed to be significantly associated with gender, TNM stage, histopathological type, smoking, family history and overall survival.
The present study identified four high-risk SNPs at 2q33 locus for Chinese lung cancer and demonstrated the shared susceptibility loci at 2q33 region for Chinese lung and esophageal cancers.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28542283</pmid><doi>10.1371/journal.pone.0177504</doi><tpages>e0177504</tpages><orcidid>https://orcid.org/0000-0002-7933-0410</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2017-05, Vol.12 (5), p.e0177504-e0177504 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1900217996 |
| source | MEDLINE; Public Library of Science (PLoS); TestCollectionTL3OpenAccess; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Analysis Biology and Life Sciences Breast cancer Case-Control Studies China - epidemiology Chromosome 2 Deoxyribonucleic acid Disease susceptibility DNA Esophageal cancer Esophageal Neoplasms - diagnosis Esophageal Neoplasms - epidemiology Esophageal Neoplasms - genetics Esophagus Family medical history Female Genetic aspects Genetic Loci - genetics Genetic Predisposition to Disease - genetics Genetic testing Genome-wide association studies Genome-Wide Association Study Genomes Genomics Genotyping Health aspects Humans Incidence Laboratories Lung cancer Lung diseases Lung Neoplasms - diagnosis Lung Neoplasms - genetics Male Medical prognosis Medical research Medicine and Health Sciences Middle Aged People and Places Polymorphism Polymorphism, Single Nucleotide Population Prognosis Risk factors Single-nucleotide polymorphism Smoking Studies Survival Survival Analysis |
| title | Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China |
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