Intranasal delivery of a bivalent norovirus vaccine formulated in an in situ gelling dry powder

The global health community is beginning to understand the burden of norovirus-associated disease, which has a significant impact in both developed and developing countries. Norovirus virus like particle (VLP)-based vaccines are currently under development and have been shown to elicit systemic and...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0177310
Hauptverfasser:	Ball, Jordan P, Springer, Michael J, Ni, Yawei, Finger-Baker, Isaac, Martinez, Juan, Hahn, Jessica, Suber, John F, DiMarco, Ashley V, Talton, James D, Cobb, Ronald R
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Adults Age Aloe - chemistry Animal models Animals Antibodies Antibody response Antigens Attachment Bacteria Baculovirus Balancing Biology and life sciences Blood cells Blood groups Buffers Caliciviridae Infections - immunology Caliciviridae Infections - prevention & control Capsid protein Carbohydrates Cation exchange Cell culture Cell density Chromatography Correlation Developing countries Diarrhea Dilution Dose-Response Relationship, Drug Epidemics Female Formulations Gastroenteritis Gels - chemistry Gene mapping Genotypes Guinea Pigs Health aspects Immune response (humoral) Immune system Immunity, Mucosal Immunization Immunogenicity Immunoglobulin A Immunoglobulin G Immunoglobulins Immunology Infections Insects LDCs Lymphocytes B Medicine and Health Sciences Neutralization Tests Norovirus Norovirus - immunology Norovirus - pathogenicity Outbreaks Physical Sciences Polysaccharides Powders - chemistry Proteins R&D Replication Research & development Research and Analysis Methods Risk factors Secretions Studies Vaccines Viral Vaccines - administration & dosage Viral Vaccines - chemistry Viral Vaccines - immunology Virus-like particles Viruses
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