Targeted DNA methylation in pericentromeres with genome editing-based artificial DNA methyltransferase

To study the impact of epigenetic changes on biological functions, the ability to manipulate the epigenetic status of certain genomic regions artificially could be an indispensable technology. "Epigenome editing" techniques have gradually emerged that apply TALE or CRISPR/Cas9 technologies...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0177764-e0177764
Hauptverfasser:	Yamazaki, Taiga, Hatano, Yu, Handa, Tetsuya, Kato, Sakiko, Hoida, Kensuke, Yamamura, Rui, Fukuyama, Takashi, Uematsu, Takayuki, Kobayashi, Noritada, Kimura, Hiroshi, Yamagata, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Base Sequence Binding Biology Biology and life sciences Biomedical research Bisulfite Cancer Cell division Cell Line Cell lines Centromere - genetics Chromosomes Clustered Regularly Interspaced Short Palindromic Repeats - genetics Coinjection CpG islands CRISPR Deoxyribonucleic acid DNA DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA Methylation - genetics DNA methyltransferase DNA sequencing DNA, Satellite - genetics Editing Embryo Implantation Embryos Engineering and Technology Enzymes Epigenetic inheritance Epigenetics Fusion protein Gametocytes Gene Editing - methods Gene expression Gene sequencing Genome editing Genomes Genomics gRNA Histone methyltransferase Mice Nucleotide sequence Oocytes Protein binding Research and Analysis Methods Satellite observation Satellite RNA Satellites Science Transcription (Genetics) Up-Regulation - genetics
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