Comparative lytic efficacy of rt-PA and ultrasound in porcine versus human clots

Porcine thrombi are employed routinely in preclinical models of ischemic stroke. In this study, we examined the differential lytic susceptibility of porcine and human whole blood clots with and without the use of microbubbles and ultrasound (US) as an adjuvant. An in vitro system equipped with time-...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0177786-e0177786
Hauptverfasser:	Huang, Shenwen, Shekhar, Himanshu, Holland, Christy K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustics Analysis Animal models Animals Biology and Life Sciences Blood Blood coagulation Blood plasma Clinical trials Coagulation Contrast Media Engineering and Technology Engineering schools Environmental engineering Exposure Health aspects Hemostasis Hemostatics Humans In vitro methods and tests In Vitro Techniques Internal medicine Internet Ischemia Lysis Medicine and Health Sciences Microbubbles Microscopy Patients Physical Sciences Plasma - chemistry Plasmas (physics) Recombinant Proteins - pharmacology Research and Analysis Methods Species Specificity Stroke Swine t-Plasminogen activator Thrombolysis Thrombosis Thrombosis - drug therapy Time-Lapse Imaging Tissue Plasminogen Activator - pharmacology Ultrasonic imaging Ultrasonography - methods Ultrasound
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