Whole brain volume changes and its correlation with clinical symptom severity in patients with schizophrenia: A DARTEL-based VBM study
The purpose of this study was to evaluate gray matter (GM) and white matter (WM) volume alterations in whole-brain structures in patients with schizophrenia and healthy controls using voxel-based morphometry (VBM), and further to assess the correlation between GM and WM volume variations and symptom...
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| description | The purpose of this study was to evaluate gray matter (GM) and white matter (WM) volume alterations in whole-brain structures in patients with schizophrenia and healthy controls using voxel-based morphometry (VBM), and further to assess the correlation between GM and WM volume variations and symptom severity in schizophrenia. A total of 22 patients with schizophrenia and 22 age-matched healthy controls participated. Magnetic resonance image data were processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Patients with schizophrenia exhibited significantly decreased GM volumes of the insula, superior temporal gyrus (STG), gyrus rectus, and anterior cingulate cortex (ACC) compared with healthy controls. The GM volumes of the STG and gyrus rectus were negatively correlated with the positive scales on the Positive and Negative Syndrome Scale (PANSS) and those of the STG and ACC were negatively correlated with the negative scales. The durations of illness in schizophrenia were negatively correlated with the GM volumes of the insula, STG, and ACC. Patients with schizophrenia exhibited significantly decreased WM volumes of the superior frontal gyrus, inferior temporal gyrus, and STG. The WM volumes of the STG were negatively correlated with the duration of illness. Our findings suggest that GM and WM volume abnormalities in the STG are associated with the psychopathology of schizophrenia. |
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A total of 22 patients with schizophrenia and 22 age-matched healthy controls participated. Magnetic resonance image data were processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Patients with schizophrenia exhibited significantly decreased GM volumes of the insula, superior temporal gyrus (STG), gyrus rectus, and anterior cingulate cortex (ACC) compared with healthy controls. The GM volumes of the STG and gyrus rectus were negatively correlated with the positive scales on the Positive and Negative Syndrome Scale (PANSS) and those of the STG and ACC were negatively correlated with the negative scales. The durations of illness in schizophrenia were negatively correlated with the GM volumes of the insula, STG, and ACC. Patients with schizophrenia exhibited significantly decreased WM volumes of the superior frontal gyrus, inferior temporal gyrus, and STG. The WM volumes of the STG were negatively correlated with the duration of illness. Our findings suggest that GM and WM volume abnormalities in the STG are associated with the psychopathology of schizophrenia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0177251</identifier><identifier>PMID: 28520743</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abnormalities ; Adult ; Age ; Algebra ; Alignment ; Anatomy ; Antipsychotics ; Anxiety ; Arches ; Attention deficit hyperactivity disorder ; Basal ganglia ; Biology and Life Sciences ; Brain ; Brain - pathology ; Brain architecture ; Brain research ; Case-Control Studies ; Classification ; Clozapine ; Cognition ; Cognitive ability ; Computer and Information Sciences ; Computer programs ; Correlation ; Cortex (cingulate) ; Cortex (frontal) ; Cortex (parietal) ; Diagnosis ; Disorders ; Drug abuse ; Drugs ; Emotions ; Etiology ; Female ; Females ; Ganglia ; Gender ; Gender differences ; Gray Matter - pathology ; Hospitals ; Humans ; Image Processing, Computer-Assisted ; Incidence ; Information dissemination ; Magnetic resonance ; Magnetic Resonance Imaging ; Male ; Males ; Matter ; Medical imaging ; Medical schools ; Medicine and Health Sciences ; Mental disorders ; Metabolites ; Neural networks ; Neuroimaging ; Neurons ; NMR ; Nuclear magnetic resonance ; Organ Size ; Parietal lobe ; Phenotype ; Prefrontal cortex ; Psychiatry ; Radiology ; Research and Analysis Methods ; Resonance ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenic Psychology ; Sex Factors ; Social interactions ; Spectroscopic analysis ; Spectroscopy ; Statistical analysis ; Statistical tests ; Studies ; Substantia alba ; Time Factors ; White Matter - pathology ; Whole brain radiotherapy ; Young Adult</subject><ispartof>PloS one, 2017-05, Vol.12 (5), p.e0177251-e0177251</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Kim et al 2017 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-dfda964862070a01e05ddaa8c074267f2e056b05453c0a9d6c23765883f1661c3</citedby><cites>FETCH-LOGICAL-c692t-dfda964862070a01e05ddaa8c074267f2e056b05453c0a9d6c23765883f1661c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435302/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435302/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79342,79343</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28520743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Gwang-Won</creatorcontrib><creatorcontrib>Kim, Yun-Hyeon</creatorcontrib><creatorcontrib>Jeong, Gwang-Woo</creatorcontrib><title>Whole brain volume changes and its correlation with clinical symptom severity in patients with schizophrenia: A DARTEL-based VBM study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The purpose of this study was to evaluate gray matter (GM) and white matter (WM) volume alterations in whole-brain structures in patients with schizophrenia and healthy controls using voxel-based morphometry (VBM), and further to assess the correlation between GM and WM volume variations and symptom severity in schizophrenia. A total of 22 patients with schizophrenia and 22 age-matched healthy controls participated. Magnetic resonance image data were processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Patients with schizophrenia exhibited significantly decreased GM volumes of the insula, superior temporal gyrus (STG), gyrus rectus, and anterior cingulate cortex (ACC) compared with healthy controls. The GM volumes of the STG and gyrus rectus were negatively correlated with the positive scales on the Positive and Negative Syndrome Scale (PANSS) and those of the STG and ACC were negatively correlated with the negative scales. The durations of illness in schizophrenia were negatively correlated with the GM volumes of the insula, STG, and ACC. Patients with schizophrenia exhibited significantly decreased WM volumes of the superior frontal gyrus, inferior temporal gyrus, and STG. The WM volumes of the STG were negatively correlated with the duration of illness. Our findings suggest that GM and WM volume abnormalities in the STG are associated with the psychopathology of schizophrenia.</description><subject>Abnormalities</subject><subject>Adult</subject><subject>Age</subject><subject>Algebra</subject><subject>Alignment</subject><subject>Anatomy</subject><subject>Antipsychotics</subject><subject>Anxiety</subject><subject>Arches</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Basal ganglia</subject><subject>Biology and Life Sciences</subject><subject>Brain</subject><subject>Brain - pathology</subject><subject>Brain architecture</subject><subject>Brain research</subject><subject>Case-Control Studies</subject><subject>Classification</subject><subject>Clozapine</subject><subject>Cognition</subject><subject>Cognitive ability</subject><subject>Computer and Information Sciences</subject><subject>Computer programs</subject><subject>Correlation</subject><subject>Cortex (cingulate)</subject><subject>Cortex (frontal)</subject><subject>Cortex (parietal)</subject><subject>Diagnosis</subject><subject>Disorders</subject><subject>Drug abuse</subject><subject>Drugs</subject><subject>Emotions</subject><subject>Etiology</subject><subject>Female</subject><subject>Females</subject><subject>Ganglia</subject><subject>Gender</subject><subject>Gender differences</subject><subject>Gray Matter - pathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Incidence</subject><subject>Information dissemination</subject><subject>Magnetic resonance</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Males</subject><subject>Matter</subject><subject>Medical imaging</subject><subject>Medical schools</subject><subject>Medicine and Health Sciences</subject><subject>Mental disorders</subject><subject>Metabolites</subject><subject>Neural networks</subject><subject>Neuroimaging</subject><subject>Neurons</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Organ Size</subject><subject>Parietal lobe</subject><subject>Phenotype</subject><subject>Prefrontal cortex</subject><subject>Psychiatry</subject><subject>Radiology</subject><subject>Research and Analysis Methods</subject><subject>Resonance</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenic Psychology</subject><subject>Sex Factors</subject><subject>Social interactions</subject><subject>Spectroscopic analysis</subject><subject>Spectroscopy</subject><subject>Statistical analysis</subject><subject>Statistical tests</subject><subject>Studies</subject><subject>Substantia alba</subject><subject>Time Factors</subject><subject>White Matter - pathology</subject><subject>Whole brain radiotherapy</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk89u1DAQxiMEoqXwBggsISE47OI_SexwQFpKgZWKKpVSjtas7WxcOfFiJ4XlAXhunHZb7aIeUA6JJr_v88x4JsueEjwljJM3F34IHbjpyndmignntCD3sn1SMTopKWb3t773skcxXmBcMFGWD7M9KgqKec72sz_fG-8MWgSwHbr0bmgNUg10SxMRdBrZPiLlQzAOeus79NP2DVLOdlaBQ3HdrnrfomguTbD9GiWTVQJNl2RXaFSN_e1XTTCdhbdohj7MTs-OjicLiEaj8_dfUOwHvX6cPajBRfNk8z7Ivn08Ojv8PDk--TQ_nB1PVFnRfqJrDVWZi1QTx4CJwYXWAEKlYmjJa5oC5QIXecEUhkqXijJeFkKwmpQlUewge37tu3I-yk0LoySiqrgQJaeJmF8T2sOFXAXbQlhLD1ZeBXxYSgi9Vc7IRc2YzglwSkUuKjOmVfMCNCO0rhdV8nq3OW1YtEar1JYAbsd0909nG7n0l7LIWcHwmMyrjUHwPwYTe9naqIxz0Bk_pLwrjEW602JEX_yD3l3dhlpCKsB2tU_nqtFUzvKKCMGLnCdqegeVHm1aq9K81TbFdwSvdwSJ6c2vfglDjHL-9fT_2ZPzXfblFtsYcH0T05COoxh3wfwaVMHHGEx922SC5bguN92Q47rIzbok2bPtC7oV3ewH-wuwzBAG</recordid><startdate>20170517</startdate><enddate>20170517</enddate><creator>Kim, Gwang-Won</creator><creator>Kim, Yun-Hyeon</creator><creator>Jeong, Gwang-Woo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20170517</creationdate><title>Whole brain volume changes and its correlation with clinical symptom severity in patients with schizophrenia: A DARTEL-based VBM study</title><author>Kim, Gwang-Won ; Kim, Yun-Hyeon ; Jeong, Gwang-Woo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-dfda964862070a01e05ddaa8c074267f2e056b05453c0a9d6c23765883f1661c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abnormalities</topic><topic>Adult</topic><topic>Age</topic><topic>Algebra</topic><topic>Alignment</topic><topic>Anatomy</topic><topic>Antipsychotics</topic><topic>Anxiety</topic><topic>Arches</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Basal ganglia</topic><topic>Biology and Life Sciences</topic><topic>Brain</topic><topic>Brain - pathology</topic><topic>Brain architecture</topic><topic>Brain research</topic><topic>Case-Control Studies</topic><topic>Classification</topic><topic>Clozapine</topic><topic>Cognition</topic><topic>Cognitive ability</topic><topic>Computer and Information Sciences</topic><topic>Computer programs</topic><topic>Correlation</topic><topic>Cortex (cingulate)</topic><topic>Cortex (frontal)</topic><topic>Cortex (parietal)</topic><topic>Diagnosis</topic><topic>Disorders</topic><topic>Drug abuse</topic><topic>Drugs</topic><topic>Emotions</topic><topic>Etiology</topic><topic>Female</topic><topic>Females</topic><topic>Ganglia</topic><topic>Gender</topic><topic>Gender differences</topic><topic>Gray Matter - pathology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Incidence</topic><topic>Information dissemination</topic><topic>Magnetic resonance</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Males</topic><topic>Matter</topic><topic>Medical imaging</topic><topic>Medical schools</topic><topic>Medicine and Health Sciences</topic><topic>Mental disorders</topic><topic>Metabolites</topic><topic>Neural networks</topic><topic>Neuroimaging</topic><topic>Neurons</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Organ Size</topic><topic>Parietal lobe</topic><topic>Phenotype</topic><topic>Prefrontal cortex</topic><topic>Psychiatry</topic><topic>Radiology</topic><topic>Research and Analysis Methods</topic><topic>Resonance</topic><topic>Schizophrenia</topic><topic>Schizophrenia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Gwang-Won</au><au>Kim, Yun-Hyeon</au><au>Jeong, Gwang-Woo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Whole brain volume changes and its correlation with clinical symptom severity in patients with schizophrenia: A DARTEL-based VBM study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-05-17</date><risdate>2017</risdate><volume>12</volume><issue>5</issue><spage>e0177251</spage><epage>e0177251</epage><pages>e0177251-e0177251</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The purpose of this study was to evaluate gray matter (GM) and white matter (WM) volume alterations in whole-brain structures in patients with schizophrenia and healthy controls using voxel-based morphometry (VBM), and further to assess the correlation between GM and WM volume variations and symptom severity in schizophrenia. A total of 22 patients with schizophrenia and 22 age-matched healthy controls participated. Magnetic resonance image data were processed using SPM8 software with diffeomorphic anatomical registration via an exponentiated Lie algebra (DARTEL) algorithm. Patients with schizophrenia exhibited significantly decreased GM volumes of the insula, superior temporal gyrus (STG), gyrus rectus, and anterior cingulate cortex (ACC) compared with healthy controls. The GM volumes of the STG and gyrus rectus were negatively correlated with the positive scales on the Positive and Negative Syndrome Scale (PANSS) and those of the STG and ACC were negatively correlated with the negative scales. The durations of illness in schizophrenia were negatively correlated with the GM volumes of the insula, STG, and ACC. Patients with schizophrenia exhibited significantly decreased WM volumes of the superior frontal gyrus, inferior temporal gyrus, and STG. The WM volumes of the STG were negatively correlated with the duration of illness. Our findings suggest that GM and WM volume abnormalities in the STG are associated with the psychopathology of schizophrenia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28520743</pmid><doi>10.1371/journal.pone.0177251</doi><tpages>e0177251</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 1932-6203 1932-6203 |
| language | eng |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Abnormalities Adult Age Algebra Alignment Anatomy Antipsychotics Anxiety Arches Attention deficit hyperactivity disorder Basal ganglia Biology and Life Sciences Brain Brain - pathology Brain architecture Brain research Case-Control Studies Classification Clozapine Cognition Cognitive ability Computer and Information Sciences Computer programs Correlation Cortex (cingulate) Cortex (frontal) Cortex (parietal) Diagnosis Disorders Drug abuse Drugs Emotions Etiology Female Females Ganglia Gender Gender differences Gray Matter - pathology Hospitals Humans Image Processing, Computer-Assisted Incidence Information dissemination Magnetic resonance Magnetic Resonance Imaging Male Males Matter Medical imaging Medical schools Medicine and Health Sciences Mental disorders Metabolites Neural networks Neuroimaging Neurons NMR Nuclear magnetic resonance Organ Size Parietal lobe Phenotype Prefrontal cortex Psychiatry Radiology Research and Analysis Methods Resonance Schizophrenia Schizophrenia - diagnosis Schizophrenic Psychology Sex Factors Social interactions Spectroscopic analysis Spectroscopy Statistical analysis Statistical tests Studies Substantia alba Time Factors White Matter - pathology Whole brain radiotherapy Young Adult |
| title | Whole brain volume changes and its correlation with clinical symptom severity in patients with schizophrenia: A DARTEL-based VBM study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T19%3A50%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Whole%20brain%20volume%20changes%20and%20its%20correlation%20with%20clinical%20symptom%20severity%20in%20patients%20with%20schizophrenia:%20A%20DARTEL-based%20VBM%20study&rft.jtitle=PloS%20one&rft.au=Kim,%20Gwang-Won&rft.date=2017-05-17&rft.volume=12&rft.issue=5&rft.spage=e0177251&rft.epage=e0177251&rft.pages=e0177251-e0177251&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0177251&rft_dat=%3Cgale_plos_%3EA491887547%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1899788672&rft_id=info:pmid/28520743&rft_galeid=A491887547&rft_doaj_id=oai_doaj_org_article_bf33d41a7228489e8620f75ad312ffb9&rfr_iscdi=true |