GPATCH3 negatively regulates RLR-mediated innate antiviral responses by disrupting the assembly of VISA signalosome

Upon viral infection, retinoic acid-inducible gene I-like receptors (RLRs) recognize viral RNA and trigger a series of signaling events, leading to the induction of type I interferons (IFNs). These processes are delicately regulated to prevent excessive and harmful immune responses. In this study, w...

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Veröffentlicht in:	PLoS pathogens 2017-04, Vol.13 (4), p.e1006328-e1006328
Hauptverfasser:	Nie, Ying, Ran, Yong, Zhang, Hong-Yan, Huang, Zhe-Fu, Pan, Zhao-Yi, Wang, Su-Yun, Wang, Yan-Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Aggregates Alternative splicing Antiviral agents Antiviral drugs Assembly Attenuation Autoimmune diseases Binding Biochemistry Biology Biology and Life Sciences Bismuth Care and treatment Carrier Proteins - genetics Carrier Proteins - immunology Cell activation Cell Line Cytokines Data acquisition Data collection Degradation Deoxyribonucleic acid Diabetes mellitus Differentiation DNA Dosage and administration Genes Genomes Heat shock Humans Immune response Immune system Immunology Infections Inflammation Interferon Interferon regulatory factor Interferon regulatory factor 3 Interferon Type I - genetics Interferon Type I - immunology Interferon-Induced Helicase, IFIH1 - genetics Interferon-Induced Helicase, IFIH1 - immunology Interleukin 1 Kinases Lysine Melanoma Membrane proteins Microorganisms Mitochondria Mitochondria - genetics Mitochondria - immunology Nephritis Pathogens Pattern recognition Peroxisomes Polymers Protein Binding Proteins Receptors, Retinoic Acid - genetics Receptors, Retinoic Acid - immunology Replication Research and analysis methods Research programs Ribonucleic acid RNA Sensors Signal Transduction Sun Toll-like receptors Transcription factors Ubiquitin-protein ligase Viral infections Virology Virus diseases Virus Diseases - genetics Virus Diseases - immunology Virus Diseases - virology Viruses
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