Circulating levels of sclerostin but not DKK1 associate with laboratory parameters of CKD-MBD

Mounting evidence indicates that a disturbed Wnt-β-catenin signaling may be involved in the pathogenesis of chronic kidney disease-mineral and bone and mineral disorder (CKD-MBD). Data on the impact of CKD on circulating levels of the Wnt antagonists sclerostin and Dickkopf related protein 1 (DKK1)...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0176411-e0176411
Hauptverfasser:	Behets, Geert J, Viaene, Liesbeth, Meijers, Björn, Blocki, Frank, Brandenburg, Vincent M, Verhulst, Anja, D'Haese, Patrick C, Evenepoel, Pieter
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Antagonists Biology and Life Sciences Biomarkers Blood platelets Blood Platelets - metabolism Bone diseases Bone Morphogenetic Proteins - blood Bone turnover Care and treatment Chronic Kidney Disease-Mineral and Bone Disorder - blood Chronic Kidney Disease-Mineral and Bone Disorder - physiopathology Chronic kidney failure Demographics Demography Diabetes Diagnosis Dialysis Dkk1 protein Female Fibroblast growth factor 23 Fibroblast growth factors Fibroblast Growth Factors - blood Genetic Markers Healthy Volunteers Hemodialysis Humans Immunology Intercellular Signaling Peptides and Proteins - blood Kidney - metabolism Kidney - pathology Kidney diseases Kidney transplantation Laboratories Male Medicine and Health Sciences Metabolism Middle Aged Mineral metabolism Minerals Nephrology Parathyroid Parathyroid hormone Parathyroid Hormone - blood Parathyroid hormones Pathogenesis Patients Peritoneal Dialysis Peritoneum Phosphatase Phosphates Phosphates - metabolism Physical Sciences Physiological aspects Regulatory mechanisms (biology) Renal Dialysis Renal function Serum levels SOST protein Vitamin D Vitamin D - blood Wnt protein Wnt Signaling Pathway - genetics β-Catenin
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