Utilizing BMP-2 muteins for treatment of multiple myeloma

Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients typically suffer from kidney malfunction and skeletal disorders. In the context of MM, the transforming growth factor β (TGFβ) member Activin A...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0174884-e0174884
Hauptverfasser:	Seher, Axel, Lagler, Charlotte, Stühmer, Thorsten, Müller-Richter, Urs Dietmar Achim, Kübler, Alexander Christian, Sebald, Walter, Müller, Thomas Dieter, Nickel, Joachim
Format:	Artikel
Sprache:	eng
Schlagworte:	Activin Adoptive transfer Affinity Amplification Anemia Angiogenesis Antineoplastic Agents - therapeutic use Apoptosis Assaying Attenuation Autocrine signalling Binding Biocompatibility Biology and Life Sciences Biophysics Biotechnology Blood Bone cancer Bone growth Bone marrow Bone morphogenetic protein 2 Bone Morphogenetic Protein 2 - metabolism Bone morphogenetic protein 7 Bone morphogenetic protein 9 Bone morphogenetic proteins Cancer Care and treatment Cell growth Competition Correlation Deposition Destruction Differentiation Disease Drug therapy Drugs Engineering Epitopes Fragmentation Health aspects Hematology Homeostasis Hospitals Humans Immunoglobulins Incidence Inhibition Interleukin 6 Kinetics Lesions Leukemia Ligands Lung cancer Lymphocytes Lymphocytes B Medical prognosis Medicine Medicine and Health Sciences Mice Multiple myeloma Multiple Myeloma - drug therapy Nickel Osteoblastogenesis Osteonecrosis Plant physiology Plasma Plasmas (physics) Proteins Reaction kinetics Reduction Rodents Signal transduction Stem cells Stimulation Surgery Thermodynamics Transforming growth factor-b Tumors Wounds
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