On the health paradox of occupational and leisure-time physical activity using objective measurements: Effects on autonomic imbalance
Leisure-time physical activity (LTPA) has considerable benefits for cardiovascular health and longevity, while occupational physical activity (OPA) is associated with an elevated cardiovascular risk. This "health paradox" may be explained by different effects on the autonomic nervous syste...
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| description | Leisure-time physical activity (LTPA) has considerable benefits for cardiovascular health and longevity, while occupational physical activity (OPA) is associated with an elevated cardiovascular risk. This "health paradox" may be explained by different effects on the autonomic nervous system from OPA and LTPA. Thus, we aimed to investigate whether objectively measured OPA and LTPA are differentially associated with autonomic regulation among workers.
The study comprised 514 blue-collar workers from the Danish cohort DPHACTO. Physical activity (i.e. walking, climbing stairs, running and cycling) was assessed objectively using accelerometers worn on the thigh, hip and trunk over multiple working days. During this period, a heart rate monitor was used to sample heart period intervals from the ECG signal. Heart rate and heart rate variability (HRV) indices were analyzed during nocturnal sleep as markers of autonomic regulation. Multiple regression analysis was used to determine the main effects of OPA and LTPA and their interaction on heart rate and HRV, adjusting for multiple confounders.
Statistically significant interaction was found between OPA and LTPA on heart rate (adjusted p |
| doi_str_mv | 10.1371/journal.pone.0177042 |
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The study comprised 514 blue-collar workers from the Danish cohort DPHACTO. Physical activity (i.e. walking, climbing stairs, running and cycling) was assessed objectively using accelerometers worn on the thigh, hip and trunk over multiple working days. During this period, a heart rate monitor was used to sample heart period intervals from the ECG signal. Heart rate and heart rate variability (HRV) indices were analyzed during nocturnal sleep as markers of autonomic regulation. Multiple regression analysis was used to determine the main effects of OPA and LTPA and their interaction on heart rate and HRV, adjusting for multiple confounders.
Statistically significant interaction was found between OPA and LTPA on heart rate (adjusted p<0.0001) and HRV indices in time (rMSSD, adjusted p = 0.004) and frequency-domains (HF, adjusted p = 0.022; LF, adjusted p = 0.033). The beneficial effect of LTPA on nocturnal heart rate and HRV clearly diminished with higher levels of OPA, and high levels of both OPA and LTPA had a detrimental effect.
We found contrasting associations for objectively measured OPA and LTPA with heart rate and HRV during sleep. Differential effects of OPA and LTPA on autonomic regulation may contribute to the physical activity health paradox.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0177042</identifier><identifier>PMID: 28472190</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Accelerometers ; Adhesive wear ; Adhesives ; Adult ; Attachment ; Attenuation ; Autonomic nervous system ; Autonomic Nervous System - physiology ; Bioinformatics ; Biology and Life Sciences ; Blood pressure ; Bradycardia ; Cardiology ; Cardiovascular diseases ; Clay ; Cleaners ; Cohort Studies ; Collection ; Computer programs ; Coronary artery disease ; Cross sections ; Cytokines ; Data acquisition ; Denmark ; Economic factors ; Electrophysiology ; Engineering and Technology ; Environmental monitoring ; Exercise ; Female ; Gene expression ; Health aspects ; Health Promotion ; Health risks ; Health-Promoting Work ; Heart diseases ; Heart rate ; Hip ; Humans ; Hypersensitivity ; Hälsofrämjande arbete ; Indicators ; Inflammation ; Male ; Medicine and Health Sciences ; Middle Aged ; Modulation ; Mortality ; Nervous system ; Occupational health ; Occupational safety and health ; Occupations ; Pain ; Parasympathetic nervous system ; Physical activity ; Population studies ; Pregnancy ; Regression analysis ; Risk ; Robustness (mathematics) ; Sleep ; Socioeconomic factors ; Wear ; Workers</subject><ispartof>PloS one, 2017-05, Vol.12 (5), p.e0177042-e0177042</ispartof><rights>COPYRIGHT 2017 Public Library of Science</rights><rights>2017 Hallman et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Hallman et al 2017 Hallman et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c795t-7ccbc57baea732f7a1a4334d9bec2dd754fccd3b3c379db87a1f56c174890a523</citedby><cites>FETCH-LOGICAL-c795t-7ccbc57baea732f7a1a4334d9bec2dd754fccd3b3c379db87a1f56c174890a523</cites><orcidid>0000-0002-2741-1868</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417644/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417644/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,551,724,777,781,861,882,2096,2915,23847,27905,27906,53772,53774,79349,79350</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28472190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:hig:diva-22365$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Chen, Xiongwen</contributor><creatorcontrib>Hallman, David M</creatorcontrib><creatorcontrib>Birk Jørgensen, Marie</creatorcontrib><creatorcontrib>Holtermann, Andreas</creatorcontrib><title>On the health paradox of occupational and leisure-time physical activity using objective measurements: Effects on autonomic imbalance</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Leisure-time physical activity (LTPA) has considerable benefits for cardiovascular health and longevity, while occupational physical activity (OPA) is associated with an elevated cardiovascular risk. This "health paradox" may be explained by different effects on the autonomic nervous system from OPA and LTPA. Thus, we aimed to investigate whether objectively measured OPA and LTPA are differentially associated with autonomic regulation among workers.
The study comprised 514 blue-collar workers from the Danish cohort DPHACTO. Physical activity (i.e. walking, climbing stairs, running and cycling) was assessed objectively using accelerometers worn on the thigh, hip and trunk over multiple working days. During this period, a heart rate monitor was used to sample heart period intervals from the ECG signal. Heart rate and heart rate variability (HRV) indices were analyzed during nocturnal sleep as markers of autonomic regulation. Multiple regression analysis was used to determine the main effects of OPA and LTPA and their interaction on heart rate and HRV, adjusting for multiple confounders.
Statistically significant interaction was found between OPA and LTPA on heart rate (adjusted p<0.0001) and HRV indices in time (rMSSD, adjusted p = 0.004) and frequency-domains (HF, adjusted p = 0.022; LF, adjusted p = 0.033). The beneficial effect of LTPA on nocturnal heart rate and HRV clearly diminished with higher levels of OPA, and high levels of both OPA and LTPA had a detrimental effect.
We found contrasting associations for objectively measured OPA and LTPA with heart rate and HRV during sleep. Differential effects of OPA and LTPA on autonomic regulation may contribute to the physical activity health paradox.</description><subject>Accelerometers</subject><subject>Adhesive wear</subject><subject>Adhesives</subject><subject>Adult</subject><subject>Attachment</subject><subject>Attenuation</subject><subject>Autonomic nervous system</subject><subject>Autonomic Nervous System - physiology</subject><subject>Bioinformatics</subject><subject>Biology and Life Sciences</subject><subject>Blood pressure</subject><subject>Bradycardia</subject><subject>Cardiology</subject><subject>Cardiovascular diseases</subject><subject>Clay</subject><subject>Cleaners</subject><subject>Cohort Studies</subject><subject>Collection</subject><subject>Computer programs</subject><subject>Coronary artery disease</subject><subject>Cross sections</subject><subject>Cytokines</subject><subject>Data acquisition</subject><subject>Denmark</subject><subject>Economic factors</subject><subject>Electrophysiology</subject><subject>Engineering and Technology</subject><subject>Environmental monitoring</subject><subject>Exercise</subject><subject>Female</subject><subject>Gene expression</subject><subject>Health aspects</subject><subject>Health Promotion</subject><subject>Health risks</subject><subject>Health-Promoting Work</subject><subject>Heart diseases</subject><subject>Heart rate</subject><subject>Hip</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Hälsofrämjande arbete</subject><subject>Indicators</subject><subject>Inflammation</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Modulation</subject><subject>Mortality</subject><subject>Nervous system</subject><subject>Occupational health</subject><subject>Occupational safety and health</subject><subject>Occupations</subject><subject>Pain</subject><subject>Parasympathetic nervous system</subject><subject>Physical activity</subject><subject>Population studies</subject><subject>Pregnancy</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Robustness (mathematics)</subject><subject>Sleep</subject><subject>Socioeconomic 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the health paradox of occupational and leisure-time physical activity using objective measurements: Effects on autonomic imbalance</title><author>Hallman, David M ; Birk Jørgensen, Marie ; Holtermann, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c795t-7ccbc57baea732f7a1a4334d9bec2dd754fccd3b3c379db87a1f56c174890a523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Accelerometers</topic><topic>Adhesive wear</topic><topic>Adhesives</topic><topic>Adult</topic><topic>Attachment</topic><topic>Attenuation</topic><topic>Autonomic nervous system</topic><topic>Autonomic Nervous System - physiology</topic><topic>Bioinformatics</topic><topic>Biology and Life Sciences</topic><topic>Blood pressure</topic><topic>Bradycardia</topic><topic>Cardiology</topic><topic>Cardiovascular diseases</topic><topic>Clay</topic><topic>Cleaners</topic><topic>Cohort 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imbalance</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2017-05-04</date><risdate>2017</risdate><volume>12</volume><issue>5</issue><spage>e0177042</spage><epage>e0177042</epage><pages>e0177042-e0177042</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Leisure-time physical activity (LTPA) has considerable benefits for cardiovascular health and longevity, while occupational physical activity (OPA) is associated with an elevated cardiovascular risk. This "health paradox" may be explained by different effects on the autonomic nervous system from OPA and LTPA. Thus, we aimed to investigate whether objectively measured OPA and LTPA are differentially associated with autonomic regulation among workers.
The study comprised 514 blue-collar workers from the Danish cohort DPHACTO. Physical activity (i.e. walking, climbing stairs, running and cycling) was assessed objectively using accelerometers worn on the thigh, hip and trunk over multiple working days. During this period, a heart rate monitor was used to sample heart period intervals from the ECG signal. Heart rate and heart rate variability (HRV) indices were analyzed during nocturnal sleep as markers of autonomic regulation. Multiple regression analysis was used to determine the main effects of OPA and LTPA and their interaction on heart rate and HRV, adjusting for multiple confounders.
Statistically significant interaction was found between OPA and LTPA on heart rate (adjusted p<0.0001) and HRV indices in time (rMSSD, adjusted p = 0.004) and frequency-domains (HF, adjusted p = 0.022; LF, adjusted p = 0.033). The beneficial effect of LTPA on nocturnal heart rate and HRV clearly diminished with higher levels of OPA, and high levels of both OPA and LTPA had a detrimental effect.
We found contrasting associations for objectively measured OPA and LTPA with heart rate and HRV during sleep. Differential effects of OPA and LTPA on autonomic regulation may contribute to the physical activity health paradox.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>28472190</pmid><doi>10.1371/journal.pone.0177042</doi><tpages>e0177042</tpages><orcidid>https://orcid.org/0000-0002-2741-1868</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PloS one, 2017-05, Vol.12 (5), p.e0177042-e0177042 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1895355880 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Accelerometers Adhesive wear Adhesives Adult Attachment Attenuation Autonomic nervous system Autonomic Nervous System - physiology Bioinformatics Biology and Life Sciences Blood pressure Bradycardia Cardiology Cardiovascular diseases Clay Cleaners Cohort Studies Collection Computer programs Coronary artery disease Cross sections Cytokines Data acquisition Denmark Economic factors Electrophysiology Engineering and Technology Environmental monitoring Exercise Female Gene expression Health aspects Health Promotion Health risks Health-Promoting Work Heart diseases Heart rate Hip Humans Hypersensitivity Hälsofrämjande arbete Indicators Inflammation Male Medicine and Health Sciences Middle Aged Modulation Mortality Nervous system Occupational health Occupational safety and health Occupations Pain Parasympathetic nervous system Physical activity Population studies Pregnancy Regression analysis Risk Robustness (mathematics) Sleep Socioeconomic factors Wear Workers |
| title | On the health paradox of occupational and leisure-time physical activity using objective measurements: Effects on autonomic imbalance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T12%3A30%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=On%20the%20health%20paradox%20of%20occupational%20and%20leisure-time%20physical%20activity%20using%20objective%20measurements:%20Effects%20on%20autonomic%20imbalance&rft.jtitle=PloS%20one&rft.au=Hallman,%20David%20M&rft.date=2017-05-04&rft.volume=12&rft.issue=5&rft.spage=e0177042&rft.epage=e0177042&rft.pages=e0177042-e0177042&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0177042&rft_dat=%3Cgale_plos_%3EA491119772%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1895355880&rft_id=info:pmid/28472190&rft_galeid=A491119772&rft_doaj_id=oai_doaj_org_article_955c318910304d7ab8500626c6f0a9c7&rfr_iscdi=true |