Periploca forrestii saponin ameliorates CIA via suppressing proinflammatory cytokines and nuclear factor kappa-B pathways

Periploca forrestii Schltr has been used as a Chinese folk medicine for the treatment of rheumatism, arthralgia and fractures. However, the anti-arthritic activity of Periploca forrestii saponin (PFS) and the active compound has still not been revealed. This study aimed to investigate the protective...

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Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0176672-e0176672
Hauptverfasser:	Bao, Chunmei, Liu, Yingqin, Sun, Xin, Xing, Congcong, Zeng, Luting, Sun, Guangchen
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance Activation Activator protein 1 Analysis Anesthesia Animals Ankle Anti-Inflammatory Agents, Non-Steroidal - pharmacology Antibodies Arthritis Arthritis, Experimental - drug therapy Arthritis, Experimental - metabolism Arthritis, Experimental - pathology Autoantibodies Biocompatibility Biology and Life Sciences Biotechnology Body weight Cardiovascular diseases Care and treatment Cells, Cultured Chemical compounds Collagen Cytokines Cytokines - metabolism Degeneration Degradation Destruction Differentiation Disease Edema Ethanol Etiology Female Flavonoids Heart Heart diseases Histology Historical account Homeostasis Humans Immune system Immunization Immunoglobulin G Immunoglobulins Inflammation Inhibition Inspection Interferon Interleukin 1 Interleukin 4 Interleukin 6 Joint diseases Laboratory animals Limbs Lung cancer Lymphocytes B Medical research Medicine and Health Sciences Mice Mice, Inbred BALB C NF-kappa B - metabolism Osteoclasts - drug effects Pain Pathology Periploca Pharmacology Pharmacy Phytotherapy Proteins Random Allocation RANK Ligand Reagents Recombinant Proteins Research and Analysis Methods Rheumatoid arthritis Rodents Saponins - pharmacology Signal Transduction - drug effects Steroids Studies Toll-like receptors Traditional Chinese medicine Transcription factors Tumor necrosis factor-TNF Visual cortex Visual perception
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