Mechanism of insulin resistance in a rat model of kidney disease and the risk of developing type 2 diabetes

Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they promote the development of type 2 diabetes is unknown. The effect of chronic kidney disease on insulin resistance was studied o...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2017-05, Vol.12 (5), p.e0176650-e0176650
Hauptverfasser:	Dion, François, Dumayne, Christopher, Henley, Nathalie, Beauchemin, Stéphanie, Arias, Edward B, Leblond, François A, Lesage, Sylvie, Lefrançois, Stéphane, Cartee, Gregory D, Pichette, Vincent
Format:	Artikel
Sprache:	eng
Schlagworte:	Accident prevention Adipose tissue Age Anatomy Anesthesia Animal models Animals Biocompatibility Biology and Life Sciences Blood glucose Brain Carbohydrate metabolism Carbohydrates Cardiovascular diseases Carriers Cellular Biology Complications and side effects Control Convergence Coronary artery disease Creatinine Cytotoxicity Death Defects Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Type 2 - metabolism Disease Progression Disease resistance Endocrinology Glucose Glucose - metabolism Glucose Transporter Type 4 - metabolism Glycosuria - metabolism Health risks Heart Heart diseases Homeostasis Human health and pathology Information dissemination Insulin resistance Insulin Resistance - physiology Intestine Kidney diseases Kidney transplantation Kidneys Life Sciences Liver - metabolism Male Medical research Medicine and Health Sciences Metabolic disorders Metabolic syndrome Metabolism Modulation Mortality Muscle, Skeletal - metabolism Muscles Nephrectomy Organs Pharmacology Physical Sciences Physiological aspects Physiology Rats, Sprague-Dawley Rats, Zucker Renal failure Renal Insufficiency, Chronic - metabolism Risk Risk factors Rivers RNA, Messenger - metabolism Rodents Sodium-Glucose Transport Proteins - metabolism Surgery Tissue Culture Techniques Toxicity Type 2 diabetes Urine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Chronic kidney disease is associated with homeostatic imbalances such as insulin resistance. However, the underlying mechanisms leading to these imbalances and whether they promote the development of type 2 diabetes is unknown. The effect of chronic kidney disease on insulin resistance was studied on two different rat strains. First, in a 5/6th nephrectomised Sprague-Dawley rat model of chronic kidney disease, we observed a correlation between the severity of chronic kidney disease and hyperglycemia as evaluated by serum fructosamine levels (p
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0176650