LC-MS-MS quantitative analysis reveals the association between FTO and DNA methylation

Fat mass and obesity-associated protein (FTO) is α-ketoglutarate-dependent dioxygenase and responsible for demethylating N6-methyladenosine (m6A) in mRNA, 3-methylthymine (m3T) in single-stranded DNA (ssDNA) and 3-methyluracil (m3U) in single-stranded RNA (ssRNA). Its other function remains unknown...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0175849-e0175849
Hauptverfasser:	Zhu, Yuting, Zhou, Guangyu, Yu, Xuebin, Xu, Qiang, Wang, Kai, Xie, Dan, Yang, Qingkai, Wang, Lina
Format:	Artikel
Sprache:	eng
Schlagworte:	Alpha-Ketoglutarate-Dependent Dioxygenase FTO - metabolism Biocatalysis Biology and life sciences Body fat Body mass index Cancer Chromatography Chromatography, Liquid Demethylation Deoxycytidine - analogs & derivatives Deoxycytidine - metabolism Deoxyribonucleic acid Dioxygenase DNA DNA Methylation Energy balance Enzymatic activity Epigenesis, Genetic Epigenetics Fertility Gene expression Genomics Health aspects HEK293 Cells Homeostasis Hospitals Humans Immunofluorescence In vivo methods and tests Ketoglutaric acid Liquid chromatography Mammals Mass Spectrometry Mass spectroscopy Metabolism Methylation mRNA N6-methyladenosine Obesity Oncology Oxidation-Reduction Physical Sciences Proteins Quantitative analysis Research and Analysis Methods Selectivity Single-stranded DNA Stem cells Substrates Transfer RNA Trends
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