Idiosyncratic recognition of UUG/UUA codons by modified nucleoside 5-taurinomethyluridine, τm5U present at 'wobble' position in anticodon loop of tRNALeu: A molecular modeling approach

Lack of naturally occurring modified nucleoside 5-taurinomethyluridine (τm5U) at the 'wobble' 34th position in tRNALeu causes mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The τm5U34 specifically recognizes UUG and UUA codons. Structural conseque...

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Veröffentlicht in:	PloS one 2017, Vol.12 (4), p.e0176756-e0176756
Hauptverfasser:	Kamble, Asmita S, Fandilolu, Prayagraj M, Sambhare, Susmit B, Sonawane, Kailas D
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Animals Anticodon - metabolism Biochemistry Bioinformatics Biology and Life Sciences Bonding Codon - metabolism Codons Crystal structure Dynamic structural analysis Encephalopathy Humans Hydrogen Hydrogen Bonding Lactic acidosis MELAS syndrome Mitochondria Molecular dynamics Molecular Dynamics Simulation Molecular modelling Myopathy Nucleosides Physical Sciences Protein Biosynthesis Recognition Research and Analysis Methods RNA - metabolism RNA, Ribosomal - metabolism RNA, Transfer, Leu - chemistry RNA, Transfer, Leu - metabolism rRNA Simulation Stroke Stroke-like episodes Transfer RNA Uridine - analogs & derivatives Uridine - metabolism
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