Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases

Plants produce an immense diversity of natural products (i.e. secondary or specialized metabolites) that offer a rich source of known and potentially new pharmaceuticals and other desirable bioproducts. The Traditional Chinese Medicinal plant Isodon rubescens (Lamiaceae) contains an array of bioacti...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0176507-e0176507
Hauptverfasser:	Pelot, Kyle A, Hagelthorn, Lynne M, Addison, J Bennett, Zerbe, Philipp
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - chemistry Alkyl and Aryl Transferases - classification Alkyl and Aryl Transferases - metabolism Amino acid sequence Analysis Angiosperms Anticancer properties Biocatalysis Biological products Biology and Life Sciences Biosynthesis Bushy stunt Cancer Catalysis Catalysts Cloning Cloning, Molecular Cyclic AMP Cytochrome Cytochrome P450 Deoxyribonucleic acid Diterpenes Diterpenes - chemistry Diterpenes - metabolism Diterpenes, Kaurane - biosynthesis Diterpenes, Kaurane - chemistry DNA DNA fingerprinting E coli Economic importance Engineering Enzymes Essential oils Foliage Forskolin Gas Chromatography-Mass Spectrometry Gene Expression Gene silencing Herbal medicine Ionization Isodon - chemistry Isodon - genetics Isodon - metabolism Lamiaceae Leaves Magnetic resonance Magnetic Resonance Spectroscopy Medicinal plants Medicine and Health Sciences Metabolism Metabolites Metabolome Mining Mutagenesis Natural products Neutralization Nicotiana - chemistry Nicotiana - metabolism NMR Nuclear magnetic resonance Oxygenation Phylogeny Physical Sciences Plant biology Plant Leaves - chemistry Plant Leaves - metabolism Plant Proteins - chemistry Plant Proteins - classification Plant Proteins - metabolism Plant tissues Plants Plants, Medicinal - chemistry Plants, Medicinal - metabolism Proteins Reaction mechanisms Residues Secondary metabolites Sesquiterpenes Species diversity Transcription Tumors
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