The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement

The lack of BTK in X-linked agammaglobulinemia (XLA) patients does not affect monocytes and polymorphonuclear cells (PMN) phenotype and functions. In this study, we show that XLA patients had an increased frequency of the intermediate monocytes subset and that BTK-deficient monocytes and PMN had a n...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0175961-e0175961
Hauptverfasser:	Cavaliere, Filomena Monica, Prezzo, Alessandro, Bilotta, Caterina, Iacobini, Metello, Quinti, Isabella
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Adhesion Adult Agammaglobulinaemia Tyrosine Kinase Agammaglobulinemia Agammaglobulinemia - drug therapy Agammaglobulinemia - genetics Agammaglobulinemia - immunology Agammaglobulinemia - pathology Age Antibodies Antigens Arachidonic acid Biology and Life Sciences Blood Blood cells Bone marrow Bruton's tyrosine kinase Calcium Calcium - metabolism Calcium Chelating Agents - pharmacology Calcium ions Case-Control Studies Cell differentiation Cell Movement - drug effects Cellular manufacture Centrifugation Chelation Defensive behavior Downstream Drug Administration Schedule Drugs E coli Functionals Gastrointestinal tract Gene Expression Regulation Genetic Diseases, X-Linked - drug therapy Genetic Diseases, X-Linked - genetics Genetic Diseases, X-Linked - immunology Genetic Diseases, X-Linked - pathology Humans Hypersensitivity Immune response Immunodeficiency Immunoglobulin G Immunoglobulins Immunoglobulins, Intravenous - therapeutic use Inhibitors Kinases Leukemia Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - pathology Lymphatic leukemia Lymphocytes B Lymphoid tissue Lymphoma Male Medicine Medicine and Health Sciences Microorganisms Middle Aged Monocytes - drug effects Monocytes - immunology Monocytes - pathology Mutation Neutropenia Neutrophils Oxidation Oxygen Phagocytosis Phagocytosis - drug effects Phenotype Physical Sciences Protein kinase Protein-Tyrosine Kinases - deficiency Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - immunology Proteins Reactive oxygen species Reactive Oxygen Species - immunology Reactive Oxygen Species - metabolism Receptors Receptors, IgG - genetics Receptors, IgG - immunology Regulations Research and Analysis Methods Respiratory Burst - drug effects Respiratory Burst - immunology Respiratory tract Rheumatoid arthritis Signal Transduction Skin Spleen
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