Occurrence of Leishmania infantum in the central nervous system of naturally infected dogs: Parasite load, viability, co-infections and histological alterations

Zoonotic visceral leishmaniasis is caused by the protozoan Leishmania infantum and little is known about the occurrence and pathogenesis of this parasite in the CNS. The aims of this study were to evaluate the occurrence, viability and load of L. infantum in the CNS, and to identify the neurological...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0175588-e0175588
Hauptverfasser:	Oliveira, Valéria da Costa, Boechat, Viviane Cardoso, Mendes Junior, Artur Augusto Velho, Madeira, Maria de Fátima, Ferreira, Luiz Claudio, Figueiredo, Fabiano Borges, Campos, Monique Paiva, de Carvalho Rodrigues, Francisco das Chagas, Carvalhaes de Oliveira, Raquel de Vasconcellos, Amendoeira, Maria Regina Reis, Menezes, Rodrigo Caldas
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Amastigotes Analysis Animals Antibodies Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Assaying Bark Biology and Life Sciences Blood-brain barrier Bone marrow Brain Causes of Central nervous system Central Nervous System - parasitology Central Nervous System - pathology Central Nervous System Diseases - cerebrospinal fluid Central Nervous System Diseases - parasitology Central Nervous System Diseases - veterinary Cerebrospinal fluid Coinfection - microbiology Coinfection - parasitology Coinfection - veterinary Cuffs Degeneration Deoxyribonucleic acid Development and progression Diagnosis DNA DNA, Protozoan - genetics Dog Diseases - microbiology Dog Diseases - parasitology Dogs Dosage and administration Ehrlichia canis - immunology Ehrlichia canis - physiology Ehrlichiosis - microbiology Ehrlichiosis - veterinary Enzymes Experimental infection Females Genital tract Glands Health aspects Histopathology Host-Parasite Interactions Host-Pathogen Interactions Immune response (humoral) Immunoassay Immunohistochemistry In Situ Hybridization Infections Inflammation Leishmania infantum - genetics Leishmania infantum - immunology Leishmania infantum - physiology Leishmaniasis Leishmaniasis, Visceral - cerebrospinal fluid Leishmaniasis, Visceral - parasitology Leishmaniasis, Visceral - veterinary Lesions Lymphocytes Lymphocytes B Males Medicine and Health Sciences Meningitis Migration Motivation Myelitis Nervous system Neurodegeneration Paralysis Parasite Load Parasites Parasitic diseases Pathogenesis Probability theory Protozoa Public health Real-Time Polymerase Chain Reaction Risk factors Seizures Semiarid environments Semiarid lands Skin Skull Spinal cord Spleen Toxoplasma - immunology Toxoplasma - physiology Toxoplasmosis Toxoplasmosis - parasitology Urban areas Vector-borne diseases Viability Visceral leishmaniasis Zoonoses
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