The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro

The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules that interfere with the HuR-ARE interaction c...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0175471
Hauptverfasser:	Kaur, Kawaljit, Wu, Xiaoqing, Fields, James K, Johnson, David K, Lan, Lan, Pratt, Miranda, Somoza, Amber D, Wang, Clay C C, Karanicolas, John, Oakley, Berl R, Xu, Liang, De Guzman, Roberto N
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - drug effects Antigens, Surface - metabolism AU Rich Elements - drug effects Benzopyrans - pharmacology Binding Sites - drug effects Biological Products - pharmacology Biology Biology and life sciences Cell growth Chemistry E coli ELAV-Like Protein 1 - antagonists & inhibitors Fluorescence Polarization - methods Fungi Fungi - chemistry Gene expression Humans In vitro methods and tests Messenger RNA Metabolites Mycology Natural products NMR Nuclear magnetic resonance Oncogenes Physical Sciences Pigments, Biological - pharmacology Protein binding Protein Binding - drug effects Protein expression Protein-protein interactions Proteins Research and analysis methods Ribonucleic acid RNA RNA - metabolism RNA, Messenger - metabolism RNA-binding protein RNA-Binding Proteins - metabolism Small Molecule Libraries - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!