Negative feedback loop of bone resorption by NFATc1-dependent induction of Cadm1

Trimethylation of histone H3 lysine 4 and lysine 27 (H3K4me3 and H3K27me3) at gene promoter regions critically regulates gene expression. Key developmental genes tend to exhibit changes in histone modification patterns from the H3K4me3/H3K27me3 bivalent pattern to the H3K4me3 monovalent pattern. Usi...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0175632
Hauptverfasser:	Nakamura, Shinya, Koyama, Takuma, Izawa, Naohiro, Nomura, Seitaro, Fujita, Takanori, Omata, Yasunori, Minami, Takashi, Matsumoto, Morio, Nakamura, Masaya, Fujita-Jimbo, Eriko, Momoi, Takashi, Miyamoto, Takeshi, Aburatani, Hiroyuki, Tanaka, Sakae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adapter proteins Animals Biology and Life Sciences Bone marrow Bone resorption Bone Resorption - genetics Bone Resorption - metabolism Bone Resorption - pathology Bone surgery Cell adhesion & migration Cell Adhesion Molecule-1 Cell Adhesion Molecules - biosynthesis Cell Adhesion Molecules - deficiency Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism Cell cycle Cell Differentiation Deoxyribonucleic acid DNA DNA methylation Epigenesis, Genetic Epigenetic inheritance Feedback, Physiological Gene Expression Genomes Histones - genetics Histones - metabolism Homeostasis Immune response Immune system Immunoglobulins - biosynthesis Immunoglobulins - deficiency Immunoglobulins - genetics Kinases Ligands Lung cancer Lymphocytes T Lysine Macrophages - cytology Macrophages - metabolism Male Medicine Medicine and Health Sciences Methylation Mice Mice, Inbred C57BL Mice, Knockout Negative feedback NFATC Transcription Factors - metabolism Orthopedics Osteoclasts (Biology) Osteoclasts - cytology Osteoclasts - metabolism Polyclonal antibodies Promoter Regions, Genetic RANK Ligand - metabolism Research and Analysis Methods Science Stem cells T cells
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