Systematic identification of phosphorylation-mediated protein interaction switches

Proteomics techniques can identify thousands of phosphorylation sites in a single experiment, the majority of which are new and lack precise information about function or molecular mechanism. Here we present a fast method to predict potential phosphorylation switches by mapping phosphorylation sites...

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Veröffentlicht in:	PLoS computational biology 2017-03, Vol.13 (3), p.e1005462-e1005462
Hauptverfasser:	Betts, Matthew J, Wichmann, Oliver, Utz, Mathias, Andre, Timon, Petsalaki, Evangelia, Minguez, Pablo, Parca, Luca, Roth, Frederick P, Gavin, Anne-Claude, Bork, Peer, Russell, Robert B
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Bioinformatics Biology and Life Sciences Computer Simulation Kinases Laboratories Models, Chemical Models, Molecular Molecular biology Mutation Observations Peptide mapping Phosphorylation Phosphotransferases - chemistry Phosphotransferases - ultrastructure Physical Sciences Protein Binding Protein Conformation Protein interaction Protein Interaction Mapping - methods Protein structure Protein-protein interactions Proteins Proteome - chemistry Proteome - ultrastructure Proteomics Research and Analysis Methods RNA polymerase Sequence Analysis, Protein - methods Structure-Activity Relationship Switches
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