Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease

Nrf2, a transcriptional activator of cell protection genes, is an attractive therapeutic target for the prevention of neurodegenerative diseases, including Alzheimer's disease (AD). Current Nrf2 activators, however, may exert toxicity and pathway over-activation can induce detrimental effects....

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Veröffentlicht in:	PLoS genetics 2017-03, Vol.13 (3), p.e1006593-e1006593
Hauptverfasser:	Kerr, Fiona, Sofola-Adesakin, Oyinkan, Ivanov, Dobril K, Gatliff, Jemma, Gomez Perez-Nievas, Beatriz, Bertrand, Hélène C, Martinez, Pedro, Callard, Rebecca, Snoeren, Inge, Cochemé, Helena M, Adcott, Jennifer, Khericha, Mobina, Castillo-Quan, Jorge Iván, Wells, Geoffrey, Noble, Wendy, Thornton, Janet, Partridge, Linda
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Activation analysis Aging Aging (artificial) Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Peptides - pharmacology Animal models Animals Animals, Genetically Modified Antisense oligonucleotides Bioinformatics Biology and Life Sciences Blotting, Western Care and treatment Cell death Cell Line, Tumor Cell survival Cells, Cultured Chemical Sciences College campuses Cortex Cysteine Data processing Disease Models, Animal Disease prevention DNA microarrays Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Drug development Enzymes Gene Expression Profiling - methods Genomes Glutamic acid Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Hippocampus Humans Incidence Kelch-Like ECH-Associated Protein 1 - genetics Kelch-Like ECH-Associated Protein 1 - metabolism Laboratories Lithium Chloride - pharmacology Longevity - drug effects Longevity - genetics Medicine and Health Sciences Mice Microscopy, Confocal Molecular biology Nervous system Neurodegeneration Neurodegenerative diseases Neurons Neurons - drug effects Neurons - metabolism Neurosciences Neurotoxicity NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nucleotide sequence Oleanolic Acid - analogs & derivatives Oleanolic Acid - pharmacology Oxidative stress Peptide Fragments - genetics Peptide Fragments - metabolism Peptide Fragments - pharmacology Phagocytosis Pharmacy Physical Sciences Protein Binding - drug effects Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA Signal transduction Therapeutics Thiadiazoles - pharmacology Toxicity Transcription factors Transgenic mice Triazoles - pharmacology University colleges β-Amyloid
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