Hepatitis C virus impairs natural killer cell activity via viral serine protease NS3

Hepatitis C virus (HCV) infection is characterized by a high frequency of chronic cases owing to the impairment of innate and adaptive immune responses. The modulation of natural killer (NK) cell functions by HCV leads to an impaired innate immune response. However, the underling mechanisms and role...

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Veröffentlicht in:	PloS one 2017-04, Vol.12 (4), p.e0175793-e0175793
Hauptverfasser:	Yang, Chang Mo, Yoon, Joo Chun, Park, Jeon Han, Lee, Jae Myun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive immunity Biology and life sciences Brain research Carbamates - chemistry Carbamates - pharmacology Cell culture Cell Line Cell Survival - drug effects Chronic infection Coculture Techniques Cytokines Cytotoxicity Degranulation Deoxyribonucleic acid DNA Down-Regulation - drug effects Enzyme-linked immunosorbent assay Flow cytometry Gastroenterology Genetic aspects Health aspects Hepacivirus - enzymology Hepatitis Hepatitis C Hepatitis C - immunology Hepatitis C - pathology Hepatitis C - virology Hepatitis C virus Humans Immune response Immune system Immunology Impairment Infections Innate immunity Interferon Interferon-gamma - analysis Interferon-gamma - metabolism Interleukin-12 - genetics Interleukin-12 - metabolism Interleukin-12 - pharmacology K562 Cells Killer cells Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Ligands Macrocyclic Compounds - chemistry Macrocyclic Compounds - pharmacology Medicine Medicine and health sciences Microscopy, Confocal Natural Cytotoxicity Triggering Receptor 1 - genetics Natural Cytotoxicity Triggering Receptor 1 - metabolism Natural Cytotoxicity Triggering Receptor 3 - genetics Natural Cytotoxicity Triggering Receptor 3 - metabolism Natural killer cells Negative selection Nonstructural proteins Penicillin Physiological aspects Protease Protease inhibitors Proteases Proteinase inhibitors Proteins Quinolines - chemistry Quinolines - pharmacology Receptors Recombinant Proteins - biosynthesis Recombinant Proteins - isolation & purification Recombinant Proteins - pharmacology Research and Analysis Methods Science Serine Serine proteinase Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - pharmacology T cell receptors Target recognition Thiazoles - chemistry Thiazoles - pharmacology Toxicity Tumor necrosis factor-TNF Viral infections Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virology Viruses
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